Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lee E et al. | Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723047 |
Qi Q et al. | Toxicological studies of wogonin in experimental animals. | 2009 | Phytother Res | pmid:19003942 |
Rushworth SA and Micheau O | Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. | 2009 | Br. J. Pharmacol. | pmid:19664138 |
Peng J et al. | Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. | 2009 | J Ethnopharmacol | pmid:19397969 |
Lee DH et al. | Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. | 2009 | Br. J. Pharmacol. | pmid:19438509 |
Yang L et al. | Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. | 2009 | Biochem. Cell Biol. | pmid:19935879 |
Kaneko T et al. | Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage. | 2009 Jul-Aug | In Vivo | pmid:19567393 |
Lu B et al. | Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. | 2009 Sep-Oct | Phytochem Anal | pmid:19533595 |
Hung CW et al. | Stem cell-based neuroprotective and neurorestorative strategies. | 2010 | Int J Mol Sci | pmid:20559500 |
Jang S et al. | Wogonin inhibits osteoclast formation induced by lipopolysaccharide. | 2010 | Phytother Res | pmid:19998398 |
Meng X et al. | Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. | 2010 | Parkinsons Dis | pmid:20976092 |
Khoo BY et al. | Apoptotic effects of chrysin in human cancer cell lines. | 2010 | Int J Mol Sci | pmid:20559509 |
Tilton R et al. | A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. | 2010 | Chin Med | pmid:20727161 |
Liang X et al. | Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry. | 2010 | J Pharm Biomed Anal | pmid:19783115 |
Ijaz AZ et al. | MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge. | 2010 | BMC Bioinformatics | pmid:20406501 |
Cui X et al. | Traditional Chinese medicine and related active compounds against hepatitis B virus infection. | 2010 | Biosci Trends | pmid:20448340 |
Ozmen A et al. | In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. | 2010 | Phytomedicine | pmid:19576743 |
Zhao Q et al. | Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. | 2010 | Toxicol. Lett. | pmid:20570612 |
Ishii K et al. | Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | 2010 | Cancer Invest. | pmid:19863351 |
Kong EK et al. | Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. | 2010 | BMB Rep | pmid:20423617 |