Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hsieh CJ et al. | Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. | 2007 | Clin Mol Allergy | pmid:18039391 |
Bak EJ et al. | Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. | 2014 | Clin Nutr | pmid:23623334 |
Bonham M et al. | Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. | 2005 | Clin. Cancer Res. | pmid:15897592 |
Samarghandian S et al. | Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. | 2011 | Clinics (Sao Paulo) | pmid:21808878 |
Tai MC et al. | Therapeutic potential of wogonin: a naturally occurring flavonoid. | 2005 | CNS Drug Rev | pmid:16007236 |
Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
Yan T et al. | Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. | 2014 | Diagn Pathol | pmid:25432585 |
Park S et al. | Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. | 2004 | Dig. Dis. Sci. | pmid:15139485 |
Chen SS et al. | Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. | 2012 | Discov Med | pmid:23200064 |
Chen SS et al. | Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. | 2012 | Discov Med | pmid:22284780 |