Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

Cross Reference

Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Acute Lung Injury D055371 33 associated lipids
Papillomavirus Infections D030361 4 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Translocation, Genetic D014178 20 associated lipids
Sarcoma 180 D012510 21 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Penile Induration D010411 4 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Lung Neoplasms D008175 171 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Glioma D005910 112 associated lipids
Gastritis D005756 27 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Brain Ischemia D002545 89 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Carcinoma D002277 18 associated lipids
Breast Neoplasms D001943 24 associated lipids
Body Weight D001835 333 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 | Total 24

PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

Download all related citations
Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
Han S et al. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. 2011 Nutr Res Pract pmid:21779522
He F et al. Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. 2012 Oncol. Rep. pmid:22665077
Hu C et al. Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway. 2015 Oncol. Rep. pmid:25846394
Chen G et al. Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice. 2016 Oncotarget pmid:27557503
Shu Q et al. Wogonin induces retinal neuron-like differentiation of bone marrow stem cells by inhibiting Notch-1 signaling. 2017 Oncotarget pmid:28415701
Xu Y et al. Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush. 2016 Oncotarget pmid:27756890
Fu R et al. Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis. 2016 Oncotarget pmid:26735336
Yang H et al. Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. 2014 Oncotarget pmid:25149543
Xu X et al. BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin. 2016 Oncotarget pmid:27027438
Vauzour D Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. 2012 Oxid Med Cell Longev pmid:22701758
Lu QY et al. Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. 2012 Pancreas pmid:22158070
Meng X et al. Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. 2010 Parkinsons Dis pmid:20976092
Li C et al. Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. 2014 Pharm Biol pmid:24102566
Shih HC and Yang LL Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. 2012 Pharm Biol pmid:22471999
Yu C et al. Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. 2013 Pharm Biol pmid:23738852
Anand P et al. Cancer is a preventable disease that requires major lifestyle changes. 2008 Pharm. Res. pmid:18626751
Zhou Q et al. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. 2010 Pharm. Res. pmid:20411407
Gao Z et al. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. 2001 Pharmacol. Res. pmid:11243719
Wakabayashi I Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages. 1999 Pharmacol. Toxicol. pmid:10401731
Lu B et al. Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. 2009 Sep-Oct Phytochem Anal pmid:19533595