Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lin CM et al. | Functional role of wogonin in anti-angiogenesis. | 2012 | Am. J. Chin. Med. | pmid:22419433 |
Ryu NH et al. | Wogonin inhibits transforming growth factor β1-induced extracellular matrix production via the p38/activator protein 1 signaling pathway in nasal polyp-derived fibroblasts. | 2016 | Am J Rhinol Allergy | pmid:27456588 |
Aung H et al. | Scutellaria baicalensis decreases ritonavir-induced nausea. | 2005 | AIDS Res Ther | pmid:16368007 |
Li DR et al. | [Effects of wogonin on inducing apoptosis of human ovarian cancer A2780 cells and telomerase activity]. | 2003 | Ai Zheng | pmid:12917023 |
Chengcheng G et al. | Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. | 2013 | Afr Health Sci | pmid:24250287 |
Seong RK et al. | Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways. | Acta Virol. | pmid:29521106 | |
Kim EJ et al. | Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel. | 2011 | Acta Physiol (Oxf) | pmid:21306568 |
Dai JY et al. | Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. | 2008 | Acta Pharmacol. Sin. | pmid:18718184 |
Liu YM et al. | Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. | 2011 | Acta Pharmacol. Sin. | pmid:21986573 |
Wohlfarth C and Efferth T | Natural products as promising drug candidates for the treatment of hepatitis B and C. | 2009 | Acta Pharmacol. Sin. | pmid:19060918 |
Zhang YM et al. | Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. | 2015 | Acta Pharmacol. Sin. | pmid:26073326 |
Salmani JMM et al. | Development of a new HPLC method for wogonin in rat plasma: Compatibility of standard and test samples. | 2017 | Acta Pharm | pmid:28858841 |
Shi G et al. | Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics. | 2017 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:28338770 |
Li C et al. | Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. | 2012 | AAPS J | pmid:22167378 |
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