Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Huynh DL et al. | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. | 2017 | Chin J Nat Med | pmid:28259249 |
Khan NM et al. | A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes. | 2017 | Sci Rep | pmid:28256567 |
Khan NM et al. | Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes. | 2017 | Free Radic. Biol. Med. | pmid:28237856 |
Chen M et al. | Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. | 2017 | Biomed. Chromatogr. | pmid:28236316 |
Wu X et al. | Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway. | 2017 | BMC Cancer | pmid:28222771 |
Kudo M et al. | Bifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport. | 2017 | PLoS ONE | pmid:28182699 |
Xu X et al. | Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation. | 2017 | Sci Rep | pmid:28150717 |
Bian J et al. | Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28117202 |
Lee HW et al. | Potent inhibition of monoamine oxidase A by decursin from Angelica gigas Nakai and by wogonin from Scutellaria baicalensis Georgi. | 2017 | Int. J. Biol. Macromol. | pmid:28109809 |
Peng MX et al. | Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin. | 2016 | Chin. Med. J. | pmid:27958228 |
Xu Y et al. | Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush. | 2016 | Oncotarget | pmid:27756890 |
Zhu N et al. | Characterization and Bioavailability of Wogonin by Different Administration Routes in Beagles. | 2016 | Med. Sci. Monit. | pmid:27744456 |
Yang T et al. | Wogonin enhances intracellular adiponectin levels and suppresses adiponectin secretion in 3T3-L1 adipocytes. | 2017 | Endocr. J. | pmid:27667474 |
Xiao W et al. | High-dose wogonin exacerbates DSS-induced colitis by up-regulating effector T cell function and inhibiting Treg cell. | 2017 | J. Cell. Mol. Med. | pmid:27641629 |
Chen G et al. | Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice. | 2016 | Oncotarget | pmid:27557503 |
Kim EH et al. | Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer. | 2016 | Apoptosis | pmid:27544755 |
Sun C et al. | Rapid Isolation and Determination of Flavones in Biological Samples Using Zinc Complexation Coupled with High-Performance Liquid Chromatography. | 2016 | Molecules | pmid:27537870 |
Liu X et al. | Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NF‑κB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling. | 2016 | Int. J. Mol. Med. | pmid:27499272 |
Ryu NH et al. | Wogonin inhibits transforming growth factor β1-induced extracellular matrix production via the p38/activator protein 1 signaling pathway in nasal polyp-derived fibroblasts. | 2016 | Am J Rhinol Allergy | pmid:27456588 |
Huang B et al. | Apoptosis Induction and Imaging of Cadmium-Telluride Quantum Dots with Wogonin in Multidrug-Resistant Leukemia K562/A02 Cell. | 2016 | J Nanosci Nanotechnol | pmid:27455661 |