Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dao TT et al. | Synthesis and biological activities of 8-arylflavones. | 2004 | Arch. Pharm. Res. | pmid:15089030 |
Dao TT et al. | Synthesis and iNOS inhibitory activities of thioflavones. | 2005 | Arch. Pharm. Res. | pmid:16042072 |
Piao HZ et al. | Neuroprotective effect of wogonin: potential roles of inflammatory cytokines. | 2004 | Arch. Pharm. Res. | pmid:15473663 |
Zhang Y et al. | V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. | 2014 | Arch. Toxicol. | pmid:23835921 |
Chen YC et al. | Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. | 2002 | Arch. Toxicol. | pmid:12107653 |
Jung SM et al. | Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. | 2007 | Arthritis Res. Ther. | pmid:17612394 |
Kauss T et al. | Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. | 2008 | Arthritis Res. Ther. | pmid:18252009 |
Coleta M et al. | Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity. | 2008 | Behav. Brain Res. | pmid:18249450 |
Zhou XQ et al. | [Flavonoids from Scutellaria baicalensis and their bioactivities]. | 2009 | Beijing Da Xue Xue Bao | pmid:19829679 |
Lee SO et al. | Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17052690 |
Nam KW et al. | The role of wogonin in controlling SOCS3 expression in neuronal cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25035930 |
Hu Y et al. | Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17069758 |
Chen S et al. | Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23063682 |
Lim JS et al. | Wogonin induces differentiation and neurite outgrowth of neural precursor cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20888794 |
Li Y et al. | Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22560901 |
Hosseinzadeh Z et al. | Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25168590 |
Zhao L et al. | Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. | 2013 | Biochem. Cell Biol. | pmid:23859016 |
Yang L et al. | Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. | 2009 | Biochem. Cell Biol. | pmid:19935879 |
Hui KM et al. | Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. | 2002 | Biochem. Pharmacol. | pmid:12392823 |
Chi YS et al. | Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. | 2003 | Biochem. Pharmacol. | pmid:14505806 |