Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nagaki Y et al. | Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. | 2001 May-Jun | Jpn. J. Ophthalmol. | pmid:11369368 |
Tian J et al. | Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15043845 |
Lim H et al. | Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. | 2011 | J. Pharmacol. Sci. | pmid:21606625 |
Enomoto R et al. | Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. | 2007 | J. Pharmacol. Sci. | pmid:17690528 |
Xie S et al. | Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9. | 2011 | J. Pharm. Pharmacol. | pmid:21235595 |
Yeh YC et al. | Acute lung injury induced by lipopolysaccharide is inhibited by wogonin in mice via reduction of Akt phosphorylation and RhoA activation. | 2016 | J. Pharm. Pharmacol. | pmid:26749510 |
Chen CY et al. | Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. | 2011 | J. Nutr. Biochem. | pmid:21190831 |
Parajuli P et al. | Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. | 2011 | J. Neurooncol. | pmid:20467782 |
Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
Ge W et al. | Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway. | 2015 | J. Mol. Neurosci. | pmid:25740014 |
Chen F et al. | Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. | 2015 | J. Mol. Neurosci. | pmid:25417142 |
Kim HS et al. | Cloning and expression of beta-glucuronidase from Lactobacillus brevis in E. coli and application in the bioconversion of baicalin and wogonoside. | 2009 | J. Microbiol. Biotechnol. | pmid:20075633 |
BÅ‚ach-Olszewska Z et al. | Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. | 2008 | J. Interferon Cytokine Res. | pmid:18771341 |
Xiao W et al. | Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity. | 2015 | J. Immunother. | pmid:25962106 |
Cao H et al. | Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. | 2009 | J. Hazard. Mater. | pmid:19577841 |
Jeong JC et al. | Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21501525 |
Lee BS et al. | Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Suppressive effect of wogonin on mite antigen-induced TARC expression. | 2007 | J. Dermatol. Sci. | pmid:17317108 |
Shi R et al. | Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21514902 |
Chen X et al. | Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12113983 |
Li HB et al. | Separation methods used for Scutellaria baicalensis active components. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15556504 |