MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma | D002277 | 18 associated lipids |
Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
Papillomavirus Infections | D030361 | 4 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Wogonin
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma | D002277 | 18 associated lipids |
Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
Papillomavirus Infections | D030361 | 4 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lin CM et al. | Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1. | 2006 | Int. Immunopharmacol. | pmid:16979123 |
Wang W et al. | Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. | 2006 | Anticancer Drugs | pmid:16926629 |
Fas SC et al. | Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. | 2006 | Blood | pmid:16931628 |
Lin CM et al. | Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2. | 2006 | Planta Med. | pmid:17024605 |
Lee SO et al. | Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17052690 |
Wang W et al. | The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo. | 2006 | Biol. Pharm. Bull. | pmid:16755005 |
Feng YL et al. | [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography]. | 2006 | Yao Xue Xue Bao | pmid:16759005 |
Chang WT et al. | Cardioprotective effects of grape seed proanthocyanidins, baicalin and wogonin: comparison between acute and chronic treatments. | 2006 | Am. J. Chin. Med. | pmid:16700106 |
Shen SC et al. | Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids. | 2006 | Neuroscience | pmid:16580779 |
Adams LS et al. | Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. | 2006 | Evid Based Complement Alternat Med | pmid:16550232 |
Chang LC and Sun SW | Micellar electrokinetic chromatography for separation of a mixture of coptis alkaloids, scute flavonoids, and rhubarb anthraquinones and bianthrones. | 2006 | J Pharm Biomed Anal | pmid:16297588 |
Huang WH et al. | Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. | 2006 | Biosci. Biotechnol. Biochem. | pmid:17031041 |
Zgórka G | Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus. | 2006 | J Chromatogr A | pmid:16364344 |
Zhao Y et al. | Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. | 2006 | Eur. J. Pharmacol. | pmid:16574098 |
Tang NY et al. | Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats. | 2006 Jul-Aug | In Vivo | pmid:16900784 |
Wang HW et al. | Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. | 2007 | Int. J. Cancer | pmid:17266043 |
Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
Jung SM et al. | Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. | 2007 | Arthritis Res. Ther. | pmid:17612394 |
Kim YH et al. | Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. | 2007 | Arch. Pharm. Res. | pmid:17366750 |
Ohta Y et al. | Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue. | 2007 | J Clin Biochem Nutr | pmid:18437211 |
Hsieh CJ et al. | Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. | 2007 | Clin Mol Allergy | pmid:18039391 |
Chang WT et al. | Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. | 2007 | Eur. J. Pharmacol. | pmid:17475241 |
Lim H and Kim HP | Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. | 2007 | Planta Med. | pmid:17886198 |
Huang GC et al. | Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. | 2007 | Int. Immunopharmacol. | pmid:17570322 |
Himeji M et al. | Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. | 2007 | Cancer Lett. | pmid:16497434 |
Qu H et al. | Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography. | 2007 | J Pharm Biomed Anal | pmid:16846714 |
Yu K et al. | Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis. | 2007 | J Pharm Biomed Anal | pmid:16989969 |
Yu J et al. | Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. | 2007 | Phytother Res | pmid:17674423 |
Seo DC et al. | Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells. | 2007 | Mol. Cancer | pmid:18034892 |
Yu JQ et al. | Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells. | 2007 | Hepatol. Res. | pmid:17300700 |
Enomoto R et al. | Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404053 |
Lee E et al. | Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404065 |
Guo Q et al. | Anti-hepatitis B virus activity of wogonin in vitro and in vivo. | 2007 | Antiviral Res. | pmid:17280723 |
Lee BS et al. | Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Suppressive effect of wogonin on mite antigen-induced TARC expression. | 2007 | J. Dermatol. Sci. | pmid:17317108 |
Enomoto R et al. | Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. | 2007 | J. Pharmacol. Sci. | pmid:17690528 |
Park HG et al. | Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. | 2007 | Eur. J. Pharmacol. | pmid:17692312 |
Heo HJ et al. | Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells. | 2007 | Phytother Res | pmid:17622975 |
Dai JY et al. | Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. | 2008 | Acta Pharmacol. Sin. | pmid:18718184 |
Gao J et al. | Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. | 2008 | J Pharm Pharm Sci | pmid:18445366 |
Coleta M et al. | Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity. | 2008 | Behav. Brain Res. | pmid:18249450 |
Anand P et al. | Cancer is a preventable disease that requires major lifestyle changes. | 2008 | Pharm. Res. | pmid:18626751 |
Makino T et al. | Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products. | 2008 | J Nat Med | pmid:18404307 |
Chow JM et al. | Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells. | 2008 | J. Cell. Biochem. | pmid:17955493 |
Chen S et al. | Down-regulation of androgen-receptor and PSA by phytochemicals. | 2008 | Int. J. Oncol. | pmid:18202763 |
Park SS et al. | Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. | 2008 | J. Cell. Biochem. | pmid:17973296 |
Cole IB et al. | Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry. | 2008 | Planta Med. | pmid:18484546 |
Kasai A et al. | Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation. | 2008 | Biol. Pharm. Bull. | pmid:18451504 |
Baumann S et al. | Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. | 2008 | Blood | pmid:18070986 |
Zhang K et al. | Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. | 2008 | Cancer Sci. | pmid:18377421 |
Lu N et al. | Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. | 2008 | Life Sci. | pmid:18378261 |