MeSH term | MeSH ID | Detail |
---|---|---|
Breast Neoplasms | D001943 | 24 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
MeSH term | MeSH ID | Detail |
---|---|---|
Breast Neoplasms | D001943 | 24 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lu N et al. | Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. | 2008 | Life Sci. | pmid:18378261 |
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Zhu N et al. | Characterization and Bioavailability of Wogonin by Different Administration Routes in Beagles. | 2016 | Med. Sci. Monit. | pmid:27744456 |
Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
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Wang J et al. | Mediating macrophage immunity with wogonin in mice with vascular inflammation. | 2017 | Mol Med Rep | pmid:28983597 |
Lu H et al. | Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis. | 2015 | Mol Med Rep | pmid:26398525 |
Kim SJ et al. | Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. | 2012 | Mol Med Rep | pmid:22992837 |
Chen LG et al. | Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. | 2008 | Mol Nutr Food Res | pmid:18496814 |
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Wang H et al. | Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. | 2014 | Mol. Carcinog. | pmid:23761018 |
Zhao L et al. | LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells. | 2016 | Mol. Carcinog. | pmid:25945460 |
Zhao Y et al. | Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. | 2015 | Mol. Carcinog. | pmid:24976450 |
Song X et al. | Wogonin influences vascular permeability via Wnt/β-catenin pathway. | 2015 | Mol. Carcinog. | pmid:24136474 |
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Yang H et al. | Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. | 2014 | Oncotarget | pmid:25149543 |
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