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Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. |
2010 |
J Pharm Biomed Anal |
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Int J Mol Sci |
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2010 |
Int J Mol Sci |
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Chin Med |
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Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. |
2011 |
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2011 |
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Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. |
2011 |
J Pharm Biomed Anal |
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Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. |
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J Neuroinflammation |
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2010 |
J Ethnobiol Ethnomed |
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Sci Pharm |
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Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. |
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2011 |
Cancer Sci. |
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2011 |
Toxicology |
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Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel. |
2011 |
Acta Physiol (Oxf) |
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The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. |
2011 |
Int J Mol Sci |
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Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. |
2011 |
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Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. |
2011 |
Mol. Cells |
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The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. |
2011 |
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2011 |
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The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway. |
2011 |
J Ethnopharmacol |
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2011 |
J. Exp. Clin. Cancer Res. |
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Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. |
2011 |
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2011 |
Funct. Integr. Genomics |
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Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. |
2011 |
Eur. J. Pharmacol. |
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Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. |
2011 |
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Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. |
2011 |
Biochim. Biophys. Acta |
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Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. |
2011 |
J. Pharmacol. Sci. |
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Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. |
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Genet. Mol. Biol. |
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Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. |
2011 |
Eur J Drug Metab Pharmacokinet |
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Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. |
2011 |
Talanta |
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Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. |
2011 |
Chin Med |
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Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. |
2011 |
Cell Death Dis |
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Anti-cancer natural products isolated from chinese medicinal herbs. |
2011 |
Chin Med |
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Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. |
2011 |
PLoS ONE |
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Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. |
2011 |
Nutr Res Pract |
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2011 |
Evid Based Complement Alternat Med |
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Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. |
2012 |
Evid Based Complement Alternat Med |
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Li Y and Martin RC |
Herbal medicine and hepatocellular carcinoma: applications and challenges. |
2011 |
Evid Based Complement Alternat Med |
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Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
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Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. |
2011 |
BMC Neurosci |
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Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. |
2011 |
J Ethnopharmacol |
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Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae. |
2011 |
Am. J. Chin. Med. |
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Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. |
2011 |
Biopharm Drug Dispos |
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A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats. |
2011 |
Toxicol Int |
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Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. |
2011 |
Acta Pharmacol. Sin. |
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Antitumor constituents from the leaves of Carya cathayensis. |
2012 |
Nat. Prod. Res. |
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Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. |
2012 |
Cancer Immunol. Immunother. |
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Stuck at the bench: Potential natural neuroprotective compounds for concussion. |
2011 |
Surg Neurol Int |
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Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). |
2010 |
Toxins (Basel) |
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Lin B |
Polyphenols and neuroprotection against ischemia and neurodegeneration. |
2011 |
Mini Rev Med Chem |
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Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. |
2012 |
J. Biol. Chem. |
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Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease. |
2011 |
J Inflamm (Lond) |
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Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. |
2012 |
J. Biol. Chem. |
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Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. |
2012 |
Pancreas |
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Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. |
2012 |
AAPS J |
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Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. |
2012 |
Int. Immunopharmacol. |
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Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. |
2012 |
Spectrochim Acta A Mol Biomol Spectrosc |
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Wu B et al. |
Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. |
2011 |
BMC Cancer |
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The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. |
2012 |
Eur. Biophys. J. |
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Li X et al. |
Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. |
2012 |
Evid Based Complement Alternat Med |
pmid:22235229
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He H et al. |
Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. |
2012 |
J Pharm Biomed Anal |
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Zhang N et al. |
A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. |
2012 |
Evid Based Complement Alternat Med |
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Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. |
2012 |
PLoS ONE |
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Chen SS et al. |
Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. |
2012 |
Discov Med |
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A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. |
2012 |
Nat. Prod. Res. |
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Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. |
2012 |
Clin Mol Allergy |
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Matsunaga T et al. |
Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. |
2012 |
Front Pharmacol |
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Li WJ et al. |
Phenolic compounds and antioxidant activities of Liriope muscari. |
2012 |
Molecules |
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Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. |
2012 |
Int J Nanomedicine |
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Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. |
2012 |
Bioorg. Med. Chem. Lett. |
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The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. |
2012 |
Eur. J. Pharmacol. |
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Kim JO et al. |
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. |
2012 |
Phytother Res |
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Functional role of wogonin in anti-angiogenesis. |
2012 |
Am. J. Chin. Med. |
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Ha SK et al. |
6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. |
2012 |
Neuropharmacology |
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Shih HC and Yang LL |
Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. |
2012 |
Pharm Biol |
pmid:22471999
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Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo. |
2012 |
Evid Based Complement Alternat Med |
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Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. |
2012 |
PLoS ONE |
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[Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. |
2012 |
Sheng Li Xue Bao |
pmid:22513472
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Li HY et al. |
Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα. |
2012 |
J. Biomed. Biotechnol. |
pmid:22536016
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Ho FM et al. |
Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. |
2012 |
J Ethnopharmacol |
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Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. |
2012 |
Biochem. Biophys. Res. Commun. |
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Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. |
2012 |
PLoS ONE |
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Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease. |
2012 |
Mediators Inflamm. |
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Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis. |
2012 |
PLoS ONE |
pmid:22590504
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Zhong Y et al. |
Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. |
2013 |
Mol. Carcinog. |
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