| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huan SK et al. | Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. | 2012 | Molecules | pmid:22634839 |
| Wilczańska-Barska A et al. | Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. | 2012 | Biotechnol. Lett. | pmid:22639092 |
| He F et al. | Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. | 2012 | Oncol. Rep. | pmid:22665077 |
| Chow SE et al. | Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. | 2012 | J. Cell. Biochem. | pmid:22689083 |
| Wang TC et al. | Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest. | 2012 | Evid Based Complement Alternat Med | pmid:22693529 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Tong L et al. | Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. | 2012 | J Pharm Biomed Anal | pmid:22703838 |
| Oshima N et al. | Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. | 2013 | J Nat Med | pmid:22729955 |
| Cheng J et al. | Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. | 2012 | Int J Nanomedicine | pmid:22745547 |
| Lee DH et al. | Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. | 2012 | Cell. Signal. | pmid:22846543 |
| Kim SG et al. | Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas. | 2013 | J Nat Med | pmid:22855402 |
| Zhu Y et al. | Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22883103 |
| Chen H et al. | A new strategy for quality control and qualitative analysis of Yinhuang preparations by HPLC-DAD-MS/MS. | 2012 | Anal Bioanal Chem | pmid:22885972 |
| Xia Y et al. | A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. | 2012 | J Pharm Biomed Anal | pmid:22906689 |
| Hayasaka S et al. | Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review. | 2012 | Am. J. Chin. Med. | pmid:22928823 |
| Tsai CF et al. | Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. | 2012 | Int J Mol Sci | pmid:22949836 |
| Im AR et al. | Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. | 2012 | Evid Based Complement Alternat Med | pmid:22969827 |
| Kim SJ et al. | Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. | 2012 | Mol Med Rep | pmid:22992837 |
| Xia B et al. | A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. | 2012 | Mol. Pharm. | pmid:23033922 |
| Chen S et al. | Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23063682 |
| Zhang M et al. | Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. | 2013 | Life Sci. | pmid:23142241 |
| Chen SS et al. | Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. | 2012 | Discov Med | pmid:23200064 |
| Kimura Y and Sumiyoshi M | Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. | 2013 | Phytomedicine | pmid:23219337 |
| Wang F et al. | Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. | 2013 | Toxicology | pmid:23246481 |
| Yang Y et al. | Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. | 2012 | PLoS ONE | pmid:23251389 |
| Wang CZ et al. | Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. | 2013 | Int. J. Oncol. | pmid:23337959 |
| Yeh CH et al. | Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. | 2014 | Environ. Toxicol. | pmid:23362215 |
| Yang L et al. | Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. | 2013 | Apoptosis | pmid:23371323 |
| Sikder MA et al. | Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. | 2014 | Phytother Res | pmid:23463646 |
| Yeh CH et al. | Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. | 2015 | Toxicol Ind Health | pmid:23592745 |
| Bak EJ et al. | Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. | 2014 | Clin Nutr | pmid:23623334 |
| Song X et al. | Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707765 |
| Yu C et al. | Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. | 2013 | Pharm Biol | pmid:23738852 |
| Wang H et al. | Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. | 2014 | Mol. Carcinog. | pmid:23761018 |
| Kim TW et al. | Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. | 2013 | Planta Med. | pmid:23818268 |
| Zhang Y et al. | V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. | 2014 | Arch. Toxicol. | pmid:23835921 |
| Zhao L et al. | Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. | 2013 | Biochem. Cell Biol. | pmid:23859016 |
| Attia SM et al. | Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. | 2013 | Food Chem. Toxicol. | pmid:23872129 |
| Wang Y et al. | GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. | 2013 | Toxicol. Lett. | pmid:23872260 |
| He L et al. | Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. | 2013 | Toxicology | pmid:23907061 |
| Kim MS et al. | Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. | 2013 | Cell Biol. Toxicol. | pmid:23955116 |
| Chirumbolo S | Anticancer properties of the flavone wogonin. | 2013 | Toxicology | pmid:23994129 |
| Xu F et al. | The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. | 2013 | J Pharm Sci | pmid:24018852 |
| Tian SS et al. | Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis. | 2014 | Fitoterapia | pmid:24096161 |
| Li C et al. | Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. | 2014 | Pharm Biol | pmid:24102566 |
| Song X et al. | Wogonin influences vascular permeability via Wnt/β-catenin pathway. | 2015 | Mol. Carcinog. | pmid:24136474 |
| Fong SY and Zuo Z | Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. | 2014 | Xenobiotica | pmid:24168065 |
| Tian J et al. | A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. | 2014 | Drug Deliv | pmid:24215357 |
| Chengcheng G et al. | Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. | 2013 | Afr Health Sci | pmid:24250287 |
| Chen XM et al. | Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. | 2013 | PLoS ONE | pmid:24265759 |