Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Carcinoma D002277 18 associated lipids
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Penile Induration D010411 4 associated lipids
Papillomavirus Infections D030361 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Authors Title Published Journal PubMed Link
Xu F et al. The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. 2013 J Pharm Sci pmid:24018852
Kimura Y and Sumiyoshi M Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. 2013 Phytomedicine pmid:23219337
Wang CZ et al. Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. 2013 Int. J. Oncol. pmid:23337959
Yang L et al. Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. 2013 Apoptosis pmid:23371323
Song X et al. Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. 2013 Toxicol. Appl. Pharmacol. pmid:23707765
Zhang M et al. Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. 2013 Life Sci. pmid:23142241
Chengcheng G et al. Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. 2013 Afr Health Sci pmid:24250287
Chen CC et al. Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. 2012 PLoS ONE pmid:22272328
Dong LL et al. An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. 2012 Food Chem pmid:25683416
Chen SS et al. Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. 2012 Discov Med pmid:22284780
Li X et al. Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. 2012 Evid Based Complement Alternat Med pmid:22235229
Pham TA et al. Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. 2012 Bioorg. Med. Chem. Lett. pmid:22366656
Ha SK et al. 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. 2012 Neuropharmacology pmid:22465818
Chen S et al. Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. 2012 Biochem. Biophys. Res. Commun. pmid:23063682
Ho FM et al. Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. 2012 J Ethnopharmacol pmid:22543166
He H et al. Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. 2012 J Pharm Biomed Anal pmid:22260968
Islam MN et al. A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. 2012 Nat. Prod. Res. pmid:22304335
Li C et al. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. 2012 AAPS J pmid:22167378
Chi DS et al. Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. 2012 Clin Mol Allergy pmid:22309647
Zhang N et al. A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. 2012 Evid Based Complement Alternat Med pmid:22272213