Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Papillomavirus Infections D030361 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Authors Title Published Journal PubMed Link
Chen S et al. Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. 2011 Cell Biol. Toxicol. pmid:20872277
Lim H et al. Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. 2011 J. Pharmacol. Sci. pmid:21606625
Mazzio EA et al. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. 2011 Int J Mol Sci pmid:21340000
Yang C et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. 2011 PLoS ONE pmid:21779360
Han S et al. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. 2011 Nutr Res Pract pmid:21779522
Zan B et al. Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. 2011 Biomed. Chromatogr. pmid:20872909
Takahashi H et al. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. 2011 Biochim. Biophys. Acta pmid:21596068
Lin CC et al. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. 2011 Int. J. Oncol. pmid:21573491
Jeong JC et al. Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. 2011 J. Exp. Clin. Cancer Res. pmid:21501525
Tang H et al. The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. 2011 BMC Biol. pmid:21418589
Enomoto R et al. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. 2011 Cancer Chemother. Pharmacol. pmid:20658136
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Dong LL et al. An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. 2012 Food Chem pmid:25683416
Pham TA et al. Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. 2012 Bioorg. Med. Chem. Lett. pmid:22366656
Chen S et al. Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. 2012 Biochem. Biophys. Res. Commun. pmid:23063682
He H et al. Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. 2012 J Pharm Biomed Anal pmid:22260968
Li HY et al. Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα. 2012 J. Biomed. Biotechnol. pmid:22536016
Islam MN et al. A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. 2012 Nat. Prod. Res. pmid:22304335
Lo YC et al. Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo. 2012 Evid Based Complement Alternat Med pmid:22474505
Kang SH et al. Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. 2012 PLoS ONE pmid:22493659