Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Papillomavirus Infections D030361 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Authors Title Published Journal PubMed Link
Chen SS et al. Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. 2012 Discov Med pmid:23200064
Chen CC et al. Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. 2012 PLoS ONE pmid:22272328
Xia Y et al. A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. 2012 J Pharm Biomed Anal pmid:22906689
Shao YX et al. The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. 2012 Eur. Biophys. J. pmid:22228220
Li J et al. Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. 2012 Spectrochim Acta A Mol Biomol Spectrosc pmid:22192416
Huang KF et al. Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. 2012 Int. Immunopharmacol. pmid:22182776
Cheng J et al. Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. 2012 Int J Nanomedicine pmid:22745547
He F et al. Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. 2012 Oncol. Rep. pmid:22665077
Shih HC and Yang LL Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. 2012 Pharm Biol pmid:22471999
Ma X et al. [Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. 2012 Sheng Li Xue Bao pmid:22513472
Wang L et al. Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. 2012 Int J Nanomedicine pmid:22359456
Chen SS et al. Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. 2012 Discov Med pmid:22284780
Li X et al. Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. 2012 Evid Based Complement Alternat Med pmid:22235229
Chow SE et al. Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. 2012 J. Cell. Biochem. pmid:22689083
Qi XF et al. Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. 2012 Evid Based Complement Alternat Med pmid:21785648
Kim SJ et al. Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. 2012 Mol Med Rep pmid:22992837
Lu QY et al. Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. 2012 Pancreas pmid:22158070
Li C et al. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. 2012 AAPS J pmid:22167378
Ding J et al. Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. 2012 J. Biol. Chem. pmid:22086925
Zhang N et al. A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. 2012 Evid Based Complement Alternat Med pmid:22272213