Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Penile Induration D010411 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Authors Title Published Journal PubMed Link
Shih YT et al. San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells. 2011 Evid Based Complement Alternat Med pmid:19339484
Chen S et al. Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. 2011 Cell Biol. Toxicol. pmid:20872277
Li C et al. Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. 2011 J Pharm Biomed Anal pmid:21051171
Lim H et al. Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. 2011 J. Pharmacol. Sci. pmid:21606625
Mazzio EA et al. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. 2011 Int J Mol Sci pmid:21340000
Yang C et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. 2011 PLoS ONE pmid:21779360
Han S et al. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. 2011 Nutr Res Pract pmid:21779522
Tan W et al. Anti-cancer natural products isolated from chinese medicinal herbs. 2011 Chin Med pmid:21777476
Chen J et al. Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study. 2011 Biomed. Chromatogr. pmid:21154891
Zan B et al. Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. 2011 Biomed. Chromatogr. pmid:20872909
Takahashi H et al. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. 2011 Biochim. Biophys. Acta pmid:21596068
Lin CC et al. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. 2011 Int. J. Oncol. pmid:21573491
Jeong JC et al. Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. 2011 J. Exp. Clin. Cancer Res. pmid:21501525
Tang H et al. The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. 2011 BMC Biol. pmid:21418589
Parajuli P et al. Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. 2011 J. Neurooncol. pmid:20467782
Enomoto R et al. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. 2011 Cancer Chemother. Pharmacol. pmid:20658136
Dong P et al. Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. 2011 J Ethnopharmacol pmid:21855619
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Su SY and Hsieh CL Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. 2011 Chin Med pmid:21740583
Hou YC et al. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. 2011 Planta Med. pmid:20957598