MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
Acute Lung Injury | D055371 | 33 associated lipids |
Neurodegenerative Diseases | D019636 | 32 associated lipids |
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
Acute Lung Injury | D055371 | 33 associated lipids |
Neurodegenerative Diseases | D019636 | 32 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Li X et al. | Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. | 2012 | Evid Based Complement Alternat Med | pmid:22235229 |
Shao YX et al. | The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. | 2012 | Eur. Biophys. J. | pmid:22228220 |
Wu B et al. | Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. | 2011 | BMC Cancer | pmid:22204275 |
Li J et al. | Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22192416 |
Huang KF et al. | Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. | 2012 | Int. Immunopharmacol. | pmid:22182776 |
Li C et al. | Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. | 2012 | AAPS J | pmid:22167378 |
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Ding J et al. | Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. | 2012 | J. Biol. Chem. | pmid:22086925 |
Lin B | Polyphenols and neuroprotection against ischemia and neurodegeneration. | 2011 | Mini Rev Med Chem | pmid:22070681 |
Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
Petraglia AL et al. | Stuck at the bench: Potential natural neuroprotective compounds for concussion. | 2011 | Surg Neurol Int | pmid:22059141 |
Dandawate S et al. | Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. | 2012 | Cancer Immunol. Immunother. | pmid:22057676 |
Cao XD et al. | Antitumor constituents from the leaves of Carya cathayensis. | 2012 | Nat. Prod. Res. | pmid:22007794 |
Liu YM et al. | Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. | 2011 | Acta Pharmacol. Sin. | pmid:21986573 |
Lee MY et al. | A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats. | 2011 | Toxicol Int | pmid:21976821 |
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Chen CY et al. | Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae. | 2011 | Am. J. Chin. Med. | pmid:21905290 |
Dong P et al. | Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. | 2011 | J Ethnopharmacol | pmid:21855619 |
Ahn SH et al. | Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. | 2011 | BMC Neurosci | pmid:21810275 |
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Li Y and Martin RC | Herbal medicine and hepatocellular carcinoma: applications and challenges. | 2011 | Evid Based Complement Alternat Med | pmid:21799681 |
Qi XF et al. | Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. | 2012 | Evid Based Complement Alternat Med | pmid:21785648 |
Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |
Yang DZ et al. | Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. | 2011 | Talanta | pmid:21726714 |
Li T et al. | Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21713461 |
Lei W et al. | Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. | 2010 | Genet. Mol. Biol. | pmid:21637484 |
Lim H et al. | Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. | 2011 | J. Pharmacol. Sci. | pmid:21606625 |
Takahashi H et al. | Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. | 2011 | Biochim. Biophys. Acta | pmid:21596068 |
Lin CC et al. | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | 2011 | Int. J. Oncol. | pmid:21573491 |
Kimura Y and Sumiyoshi M | Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. | 2011 | Eur. J. Pharmacol. | pmid:21549115 |
Park NI et al. | Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. | 2011 | Funct. Integr. Genomics | pmid:21538138 |
Shi R et al. | Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21514902 |
Jeong JC et al. | Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21501525 |
Zeng H et al. | The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway. | 2011 | J Ethnopharmacol | pmid:21466840 |
Zhao L et al. | Developmental toxicity and genotoxicity studies of wogonin. | 2011 | Regul. Toxicol. Pharmacol. | pmid:21459121 |
Gao J et al. | The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21457722 |
Yu JS and Kim AK | Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. | 2011 | Mol. Cells | pmid:21448585 |
Lee YM et al. | Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21436723 |
Tang H et al. | The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. | 2011 | BMC Biol. | pmid:21418589 |
Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
Kim EJ et al. | Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel. | 2011 | Acta Physiol (Oxf) | pmid:21306568 |
Chen P et al. | Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. | 2011 | Toxicology | pmid:21295103 |
Yang L et al. | Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. | 2011 | Cancer Sci. | pmid:21244577 |
Xie S et al. | Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9. | 2011 | J. Pharm. Pharmacol. | pmid:21235595 |
Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
Chow SE et al. | Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. | 2011 | Cancer Chemother. Pharmacol. | pmid:21207227 |
Chen CY et al. | Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. | 2011 | J. Nutr. Biochem. | pmid:21190831 |
Katrahalli U et al. | Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods. | 2010 Oct-Dec | Sci Pharm | pmid:21179322 |
Ye G et al. | Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry. | 2010 | Chem. Biodivers. | pmid:21162005 |
Chen J et al. | Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study. | 2011 | Biomed. Chromatogr. | pmid:21154891 |
Kunwar RM et al. | Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | 2010 | J Ethnobiol Ethnomed | pmid:21144003 |
Jeong HJ et al. | Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. | 2010 | J Neuroinflammation | pmid:21108840 |
Wei L et al. | Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. | 2010 | J. Cell. Biochem. | pmid:21053277 |
Li C et al. | Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. | 2011 | J Pharm Biomed Anal | pmid:21051171 |
Meng X et al. | Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. | 2010 | Parkinsons Dis | pmid:20976092 |
Hou YC et al. | Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. | 2011 | Planta Med. | pmid:20957598 |
Lim JS et al. | Wogonin induces differentiation and neurite outgrowth of neural precursor cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20888794 |
Zan B et al. | Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. | 2011 | Biomed. Chromatogr. | pmid:20872909 |
Chen S et al. | Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. | 2011 | Cell Biol. Toxicol. | pmid:20872277 |
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Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
Enomoto R et al. | Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. | 2011 | Cancer Chemother. Pharmacol. | pmid:20658136 |
Zhao Q et al. | Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. | 2010 | Toxicol. Lett. | pmid:20570612 |
Khoo BY et al. | Apoptotic effects of chrysin in human cancer cell lines. | 2010 | Int J Mol Sci | pmid:20559509 |
Hung CW et al. | Stem cell-based neuroprotective and neurorestorative strategies. | 2010 | Int J Mol Sci | pmid:20559500 |
Parajuli P et al. | Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. | 2011 | J. Neurooncol. | pmid:20467782 |
Lin CW et al. | 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression. | 2010 | J. Cell. Physiol. | pmid:20458747 |
Gao J et al. | Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. | 2010 | J Pharm Biomed Anal | pmid:20457505 |
Cui X et al. | Traditional Chinese medicine and related active compounds against hepatitis B virus infection. | 2010 | Biosci Trends | pmid:20448340 |
Feng J et al. | Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. | 2010 | J Pharm Biomed Anal | pmid:20430560 |
Kong EK et al. | Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. | 2010 | BMB Rep | pmid:20423617 |
Zhou Q et al. | Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. | 2010 | Pharm. Res. | pmid:20411407 |
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Ni Y et al. | Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches. | 2010 | Anal. Chim. Acta | pmid:20206002 |
Li Y et al. | Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers. | 2010 | J Pharm Biomed Anal | pmid:20138726 |
You J et al. | On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. | 2010 | J Chromatogr A | pmid:20138285 |
Kaneko T et al. | Inhibition of prostaglandin E2 production by flavone and its related compounds. | In Vivo | pmid:20133976 | |
Gurung SK et al. | Inhibition of prostaglandin E2 production by synthetic wogonin analogs. | 2009 | Arch. Pharm. Res. | pmid:20091262 |
Kim HS et al. | Cloning and expression of beta-glucuronidase from Lactobacillus brevis in E. coli and application in the bioconversion of baicalin and wogonoside. | 2009 | J. Microbiol. Biotechnol. | pmid:20075633 |
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Chen B et al. | Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells. | 2009 | Int J Nanomedicine | pmid:20011242 |
Jang S et al. | Wogonin inhibits osteoclast formation induced by lipopolysaccharide. | 2010 | Phytother Res | pmid:19998398 |
Yang L et al. | Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. | 2009 | Biochem. Cell Biol. | pmid:19935879 |
Ishii K et al. | Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | 2010 | Cancer Invest. | pmid:19863351 |
Wang CZ et al. | Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. | 2010 | Phytomedicine | pmid:19836937 |
Zhou XQ et al. | [Flavonoids from Scutellaria baicalensis and their bioactivities]. | 2009 | Beijing Da Xue Xue Bao | pmid:19829679 |
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Lee E et al. | Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723047 |
Calvo TR et al. | Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts. | 2011 | Evid Based Complement Alternat Med | pmid:19696193 |
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Ding XF et al. | [Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy]. | 2009 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:19650472 |