| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Penile Induration | D010411 | 4 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wilczańska-Barska A et al. | Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. | 2012 | Biotechnol. Lett. | pmid:22639092 |
| Wang Z et al. | Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells. | 2003 | BJU Int. | pmid:14616461 |
| Fas SC et al. | Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. | 2006 | Blood | pmid:16931628 |
| Ma Z et al. | Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. | 2005 | Blood | pmid:15626742 |
| Baumann S et al. | Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. | 2008 | Blood | pmid:18070986 |
| Ku SK and Bae JS | Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo. | 2015 | BMB Rep | pmid:25739393 |
| Kong EK et al. | Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. | 2010 | BMB Rep | pmid:20423617 |
| Scuro LS et al. | Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. | 2004 | BMC Biochem. | pmid:15102332 |
| Ijaz AZ et al. | MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge. | 2010 | BMC Bioinformatics | pmid:20406501 |
| Tang H et al. | The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. | 2011 | BMC Biol. | pmid:21418589 |
| Wu X et al. | Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway. | 2017 | BMC Cancer | pmid:28222771 |
| Wu B et al. | Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. | 2011 | BMC Cancer | pmid:22204275 |
| Huynh DL et al. | Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression. | 2017 | BMC Complement Altern Med | pmid:28606135 |
| Ahn SH et al. | Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. | 2011 | BMC Neurosci | pmid:21810275 |
| Rushworth SA and Micheau O | Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. | 2009 | Br. J. Pharmacol. | pmid:19664138 |
| Lee DH et al. | Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. | 2009 | Br. J. Pharmacol. | pmid:19438509 |
| Lee HH et al. | Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. | 2003 | Brain Res. | pmid:12965234 |
| Chow SE et al. | Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. | 2011 | Cancer Chemother. Pharmacol. | pmid:21207227 |
| Enomoto R et al. | Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. | 2011 | Cancer Chemother. Pharmacol. | pmid:20658136 |
| Dandawate S et al. | Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. | 2012 | Cancer Immunol. Immunother. | pmid:22057676 |
| Ishii K et al. | Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | 2010 | Cancer Invest. | pmid:19863351 |
| Himeji M et al. | Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. | 2007 | Cancer Lett. | pmid:16497434 |
| Yang L et al. | Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. | 2011 | Cancer Sci. | pmid:21244577 |
| Zhang K et al. | Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. | 2008 | Cancer Sci. | pmid:18377421 |
| Li-Weber M | New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. | 2009 | Cancer Treat. Rev. | pmid:19004559 |
| Kim MS et al. | Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. | 2013 | Cell Biol. Toxicol. | pmid:23955116 |
| Chen S et al. | Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. | 2011 | Cell Biol. Toxicol. | pmid:20872277 |
| Yao J et al. | NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. | 2014 | Cell Death Dis | pmid:24901054 |
| Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
| Chen S et al. | Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. | 2015 | Cell. Mol. Neurobiol. | pmid:25504431 |
| Xu S et al. | Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro. | 2015 | Cell. Mol. Neurobiol. | pmid:25381475 |
| Sukkar B et al. | Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin. | 2018 | Cell. Physiol. Biochem. | pmid:30453283 |
| Al-Maghout T et al. | P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes. | 2017 | Cell. Physiol. Biochem. | pmid:28813704 |
| Lee DH et al. | Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. | 2012 | Cell. Signal. | pmid:22846543 |
| Willimott S et al. | An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells. | 2009 | Chem Cent J | pmid:19785738 |
| Ye G et al. | Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry. | 2010 | Chem. Biodivers. | pmid:21162005 |
| Su S et al. | Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis. | 2008 | Chem. Biodivers. | pmid:18651621 |
| Tan CX et al. | Activities of wogonin analogs and other flavones against Flavobacterium columnare. | 2015 | Chem. Biodivers. | pmid:25676507 |
| Khan NM et al. | Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes. | 2017 | Chem. Biol. Interact. | pmid:28688942 |
| Xie LH et al. | Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography. | 2002 | Chem. Pharm. Bull. | pmid:12130846 |
| Huang WH et al. | Novel synthesis of flavonoids of Scutellaria baicalensis Georgi. | 2003 | Chem. Pharm. Bull. | pmid:12612426 |
| Li YQ et al. | Two new alkaloids from Capparis himalayensis. | 2008 | Chem. Pharm. Bull. | pmid:18239306 |
| Liu RX et al. | Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. | 2017 | Chin J Nat Med | pmid:28284428 |
| Huynh DL et al. | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. | 2017 | Chin J Nat Med | pmid:28259249 |
| Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
| Tilton R et al. | A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. | 2010 | Chin Med | pmid:20727161 |
| Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |
| Xu PP et al. | Wogonin Inhibits Growth of Mantle Cell Lymphoma Cells through Nuclear Factor-κB Signaling Pathway. | 2018 | Chin. Med. J. | pmid:29451160 |
| Peng MX et al. | Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin. | 2016 | Chin. Med. J. | pmid:27958228 |
| Chi DS et al. | Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. | 2012 | Clin Mol Allergy | pmid:22309647 |