Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Penile Induration D010411 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Authors Title Published Journal PubMed Link
Xu X et al. Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway. 2014 Biochem. Pharmacol. pmid:25264278
Lee W et al. Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo. 2015 Inflammation pmid:25249339
Marsh Z et al. Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. 2014 Phytochemistry pmid:25236693
Kwak S et al. Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. 2014 Toxicol. Appl. Pharmacol. pmid:25223693
Zhao K et al. Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. 2014 PLoS ONE pmid:25203554
Hosseinzadeh Z et al. Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes. 2014 Biochem. Biophys. Res. Commun. pmid:25168590
Yang H et al. Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. 2014 Oncotarget pmid:25149543
Huang KF et al. [Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells]. 2014 Zhongguo Zhong Yao Za Zhi pmid:25039187
Nam KW et al. The role of wogonin in controlling SOCS3 expression in neuronal cells. 2014 Biochem. Biophys. Res. Commun. pmid:25035930
Ku SK and Bae JS Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. 2014 Fitoterapia pmid:25020199
Zhao Y et al. Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. 2015 Mol. Carcinog. pmid:24976450
Yao J et al. NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. 2014 Cell Death Dis pmid:24901054
Polier G et al. Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263. 2015 Int. J. Cancer pmid:24895203
Zhao K et al. Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling. 2014 Eur. J. Pharmacol. pmid:24858369
Fong SY et al. Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. 2014 J Pharm Biomed Anal pmid:24803030
Talbi A et al. Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. 2014 Molecules pmid:24786691
Yao J et al. Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. 2014 Immunology pmid:24766487
Qian C et al. Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells. 2014 Free Radic. Res. pmid:24666416
Gong WY et al. Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro. 2014 Int. J. Oncol. pmid:24604573
Shin HS et al. Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. 2014 Molecules pmid:24566319
Zhang F and Wang G A review of non-nucleoside anti-hepatitis B virus agents. 2014 Eur J Med Chem pmid:24549242
Zhou M et al. Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway. 2014 Vascul. Pharmacol. pmid:24534483
Zhou YQ et al. [Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. 2013 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:24490490
Liu J et al. Screening of osteoanagenesis-active compounds from Scutellaria baicalensis Georgi by hPDLC/CMC-online-HPLC/MS. 2014 Fitoterapia pmid:24393619
Lin CC et al. Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. 2013 Nov-Dec In Vivo pmid:24292576
Chen XM et al. Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. 2013 PLoS ONE pmid:24265759
Chengcheng G et al. Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. 2013 Afr Health Sci pmid:24250287
Tian J et al. A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. 2014 Drug Deliv pmid:24215357
Fong SY and Zuo Z Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. 2014 Xenobiotica pmid:24168065
Song X et al. Wogonin influences vascular permeability via Wnt/β-catenin pathway. 2015 Mol. Carcinog. pmid:24136474
Li C et al. Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. 2014 Pharm Biol pmid:24102566
Tian SS et al. Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis. 2014 Fitoterapia pmid:24096161
Xu F et al. The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. 2013 J Pharm Sci pmid:24018852
Chirumbolo S Anticancer properties of the flavone wogonin. 2013 Toxicology pmid:23994129
Kim MS et al. Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. 2013 Cell Biol. Toxicol. pmid:23955116
He L et al. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. 2013 Toxicology pmid:23907061
Wang Y et al. GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. 2013 Toxicol. Lett. pmid:23872260
Attia SM et al. Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. 2013 Food Chem. Toxicol. pmid:23872129
Zhao L et al. Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. 2013 Biochem. Cell Biol. pmid:23859016
Zhang Y et al. V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. 2014 Arch. Toxicol. pmid:23835921
Kim TW et al. Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. 2013 Planta Med. pmid:23818268
Wang H et al. Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. 2014 Mol. Carcinog. pmid:23761018
Yu C et al. Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. 2013 Pharm Biol pmid:23738852
Song X et al. Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. 2013 Toxicol. Appl. Pharmacol. pmid:23707765
Bak EJ et al. Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. 2014 Clin Nutr pmid:23623334
Yeh CH et al. Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. 2015 Toxicol Ind Health pmid:23592745
Sikder MA et al. Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. 2014 Phytother Res pmid:23463646
Yang L et al. Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. 2013 Apoptosis pmid:23371323
Yeh CH et al. Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. 2014 Environ. Toxicol. pmid:23362215
Wang CZ et al. Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. 2013 Int. J. Oncol. pmid:23337959