MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
Acute Lung Injury | D055371 | 33 associated lipids |
Neurodegenerative Diseases | D019636 | 32 associated lipids |
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
Acute Lung Injury | D055371 | 33 associated lipids |
Neurodegenerative Diseases | D019636 | 32 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Marsh Z et al. | Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. | 2014 | Phytochemistry | pmid:25236693 |
Hong ZP et al. | Wogonin exacerbates the cytotoxic effect of oxaliplatin by inducing nitrosative stress and autophagy in human gastric cancer cells. | 2018 | Phytomedicine | pmid:29433678 |
Kimura Y and Sumiyoshi M | Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. | 2013 | Phytomedicine | pmid:23219337 |
Wang CZ et al. | Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. | 2010 | Phytomedicine | pmid:19836937 |
Huang ST et al. | Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. | 2010 | Phytomedicine | pmid:19577445 |
Ozmen A et al. | In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. | 2010 | Phytomedicine | pmid:19576743 |
Sikder MA et al. | Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. | 2014 | Phytother Res | pmid:23463646 |
Jang S et al. | Wogonin inhibits osteoclast formation induced by lipopolysaccharide. | 2010 | Phytother Res | pmid:19998398 |
Pal M et al. | Antifungal activity of wogonin. | 2003 | Phytother Res | pmid:14669259 |
Qi Q et al. | Toxicological studies of wogonin in experimental animals. | 2009 | Phytother Res | pmid:19003942 |
Yu J et al. | Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. | 2007 | Phytother Res | pmid:17674423 |
Kim JO et al. | Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. | 2012 | Phytother Res | pmid:22388989 |
Heo HJ et al. | Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells. | 2007 | Phytother Res | pmid:17622975 |
Chaudhuri PK et al. | Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. | 2004 | Phytother Res | pmid:15022161 |
Murch SJ et al. | A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds. | 2004 | Plant Cell Rep. | pmid:15449017 |
Chuang HN et al. | Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line. | 2005 | Planta Med. | pmid:15931583 |
Hong T et al. | Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice. | 2002 | Planta Med. | pmid:11914968 |
Chang WH et al. | Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. | 2002 | Planta Med. | pmid:11859462 |
Lin CM et al. | Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2. | 2006 | Planta Med. | pmid:17024605 |
Park EJ et al. | Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells. | 2005 | Planta Med. | pmid:16206047 |
Lim H and Kim HP | Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. | 2007 | Planta Med. | pmid:17886198 |
Tsai TH et al. | Determination of wogonin in rat plasma by liquid chromatography and its pharmacokinetic application. | 1996 | Planta Med. | pmid:8693042 |
Chiu JH et al. | Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line. | 2002 | Planta Med. | pmid:12451498 |
Cole IB et al. | Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry. | 2008 | Planta Med. | pmid:18484546 |
Parajuli P et al. | In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. | 2009 | Planta Med. | pmid:19031366 |
Kim BR et al. | Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. | 2001 | Planta Med. | pmid:11488450 |
Kim TW et al. | Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. | 2013 | Planta Med. | pmid:23818268 |
Huang RL et al. | Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. | 2000 | Planta Med. | pmid:11199123 |
Hou YC et al. | Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. | 2011 | Planta Med. | pmid:20957598 |
Chen CC et al. | Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. | 2012 | PLoS ONE | pmid:22272328 |
Yang Y et al. | Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. | 2012 | PLoS ONE | pmid:23251389 |
Chen XM et al. | Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. | 2013 | PLoS ONE | pmid:24265759 |
Ci X et al. | Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. | 2012 | PLoS ONE | pmid:22563373 |
Liu J et al. | Deep Sequencing of the Scutellaria baicalensis Georgi Transcriptome Reveals Flavonoid Biosynthetic Profiling and Organ-Specific Gene Expression. | 2015 | PLoS ONE | pmid:26317778 |
Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
Kudo M et al. | Bifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport. | 2017 | PLoS ONE | pmid:28182699 |
Zhao K et al. | Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. | 2014 | PLoS ONE | pmid:25203554 |
Zhu J et al. | Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis. | 2012 | PLoS ONE | pmid:22590504 |
Kang SH et al. | Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. | 2012 | PLoS ONE | pmid:22493659 |
Chi YS and Kim HP | Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589400 |
Ong ES et al. | Proteomic analysis of mouse liver for the evaluation of effects of Scutellariae radix by liquid chromatography with tandem mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15468106 |
Zhao L et al. | Developmental toxicity and genotoxicity studies of wogonin. | 2011 | Regul. Toxicol. Pharmacol. | pmid:21459121 |
Zhao Q et al. | A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. | 2016 | Sci Adv | pmid:27152350 |
Katrahalli U et al. | Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods. | 2010 Oct-Dec | Sci Pharm | pmid:21179322 |
Xu X et al. | Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation. | 2017 | Sci Rep | pmid:28150717 |
Khan NM et al. | A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes. | 2017 | Sci Rep | pmid:28256567 |
Ma X et al. | [Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. | 2012 | Sheng Li Xue Bao | pmid:22513472 |
Zhou YQ et al. | [Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. | 2013 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:24490490 |
Li J et al. | Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22192416 |
Petraglia AL et al. | Stuck at the bench: Potential natural neuroprotective compounds for concussion. | 2011 | Surg Neurol Int | pmid:22059141 |
Yang DZ et al. | Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. | 2011 | Talanta | pmid:21726714 |
Yeh CH et al. | Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. | 2015 | Toxicol Ind Health | pmid:23592745 |
Lee MY et al. | A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats. | 2011 | Toxicol Int | pmid:21976821 |
Kwak S et al. | Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25223693 |
Song X et al. | Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707765 |
Gao J et al. | The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21457722 |
Wang Y et al. | GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. | 2013 | Toxicol. Lett. | pmid:23872260 |
Chen TJ et al. | Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase. | 2004 | Toxicol. Lett. | pmid:14700523 |
Zhao Q et al. | Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. | 2010 | Toxicol. Lett. | pmid:20570612 |
Wang F et al. | Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. | 2013 | Toxicology | pmid:23246481 |
He L et al. | Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. | 2013 | Toxicology | pmid:23907061 |
Chirumbolo S | Anticancer properties of the flavone wogonin. | 2013 | Toxicology | pmid:23994129 |
Chen P et al. | Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. | 2011 | Toxicology | pmid:21295103 |
Kim HM et al. | The nitric oxide-producing activities of Scutellaria baicalensis. | 1999 | Toxicology | pmid:10463767 |
Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
Ikemoto S et al. | Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. | 2000 | Urology | pmid:10840124 |
Huang Y et al. | Wogonin inhibits LPS-induced vascular permeability via suppressing MLCK/MLC pathway. | 2015 | Vascul. Pharmacol. | pmid:25956732 |
Zhou M et al. | Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway. | 2014 | Vascul. Pharmacol. | pmid:24534483 |
Fong SY and Zuo Z | Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. | 2014 | Xenobiotica | pmid:24168065 |
Isobe T et al. | [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. | 2002 | Yakugaku Zasshi | pmid:11968842 |
Feng YL et al. | [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography]. | 2006 | Yao Xue Xue Bao | pmid:16759005 |
Du Y et al. | [Determination of wogonin in rat plasma by liquid chromatography-tandem mass spectrometry]. | 2002 | Yao Xue Xue Bao | pmid:12579842 |
Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
Huang KF et al. | [Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25039187 |
Du CF et al. | [Studies on chemical constituents in bark of dictamnus dasycarpus]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16400943 |