MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
Acute Lung Injury | D055371 | 33 associated lipids |
Neurodegenerative Diseases | D019636 | 32 associated lipids |
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Penile Induration | D010411 | 4 associated lipids |
Acute Lung Injury | D055371 | 33 associated lipids |
Neurodegenerative Diseases | D019636 | 32 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
Ruibin J et al. | Therapy Effects of Wogonin on Ovarian Cancer Cells. | 2017 | Biomed Res Int | pmid:29181409 |
Li C et al. | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. | 2005 | Biomed. Chromatogr. | pmid:15627280 |
Chen M et al. | Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. | 2017 | Biomed. Chromatogr. | pmid:28236316 |
Zhang YY et al. | Comparative study of Scutellaria planipes and Scutellaria baicalensis. | 1998 Jan-Feb | Biomed. Chromatogr. | pmid:9470972 |
Chen J et al. | Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study. | 2011 | Biomed. Chromatogr. | pmid:21154891 |
Zan B et al. | Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. | 2011 | Biomed. Chromatogr. | pmid:20872909 |
Chen J et al. | Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro. | 2017 | Biomed. Pharmacother. | pmid:28486193 |
Tian J et al. | Interaction of wogonin with bovine serum albumin. | 2005 | Bioorg. Med. Chem. | pmid:15911327 |
Qin X et al. | Novel platinum(IV) complexes conjugated with a wogonin derivative as multi-targeted anticancer agents. | 2017 | Bioorg. Med. Chem. | pmid:28314511 |
Pham TA et al. | Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22366656 |
Tran TD et al. | Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19233646 |
Bian J et al. | Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28117202 |
Li C et al. | Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. | 2011 | Biopharm Drug Dispos | pmid:21928297 |
Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
Cui X et al. | Traditional Chinese medicine and related active compounds against hepatitis B virus infection. | 2010 | Biosci Trends | pmid:20448340 |
Yamashita Y et al. | Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation. | 2017 | Biosci. Biotechnol. Biochem. | pmid:28345416 |
Huang WH et al. | Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. | 2006 | Biosci. Biotechnol. Biochem. | pmid:17031041 |
Lim BO et al. | Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12834292 |
Lim BO | Efficacy of wogonin in the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618621 |