Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Penile Induration D010411 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Authors Title Published Journal PubMed Link
Wang HW et al. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. 2007 Int. J. Cancer pmid:17266043
Jung SM et al. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. 2007 Arthritis Res. Ther. pmid:17612394
Kim YH et al. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. 2007 Arch. Pharm. Res. pmid:17366750
Chang WT et al. Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. 2007 Eur. J. Pharmacol. pmid:17475241
Lim H and Kim HP Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. 2007 Planta Med. pmid:17886198
Huang GC et al. Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. 2007 Int. Immunopharmacol. pmid:17570322
Yu K et al. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis. 2007 J Pharm Biomed Anal pmid:16989969
Yu J et al. Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. 2007 Phytother Res pmid:17674423
Seo DC et al. Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells. 2007 Mol. Cancer pmid:18034892
Yu JQ et al. Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells. 2007 Hepatol. Res. pmid:17300700
Enomoto R et al. Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. 2007 Ann. N. Y. Acad. Sci. pmid:17404053
Lee E et al. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. 2007 Ann. N. Y. Acad. Sci. pmid:17404065
Guo Q et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo. 2007 Antiviral Res. pmid:17280723
Lee BS et al. Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Suppressive effect of wogonin on mite antigen-induced TARC expression. 2007 J. Dermatol. Sci. pmid:17317108
Enomoto R et al. Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. 2007 J. Pharmacol. Sci. pmid:17690528
Park HG et al. Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. 2007 Eur. J. Pharmacol. pmid:17692312
Heo HJ et al. Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells. 2007 Phytother Res pmid:17622975
Gao J et al. Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. 2008 J Pharm Pharm Sci pmid:18445366
Anand P et al. Cancer is a preventable disease that requires major lifestyle changes. 2008 Pharm. Res. pmid:18626751
Kasai A et al. Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation. 2008 Biol. Pharm. Bull. pmid:18451504