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Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. |
2012 |
Molecules |
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Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. |
2012 |
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Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. |
2012 |
Oncol. Rep. |
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Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. |
2012 |
J. Cell. Biochem. |
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Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest. |
2012 |
Evid Based Complement Alternat Med |
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2012 |
Oxid Med Cell Longev |
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Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. |
2012 |
J Pharm Biomed Anal |
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Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. |
2013 |
J Nat Med |
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Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. |
2012 |
Int J Nanomedicine |
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Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. |
2012 |
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J Nat Med |
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A new strategy for quality control and qualitative analysis of Yinhuang preparations by HPLC-DAD-MS/MS. |
2012 |
Anal Bioanal Chem |
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A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. |
2012 |
J Pharm Biomed Anal |
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Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review. |
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Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. |
2012 |
Int J Mol Sci |
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Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. |
2012 |
Evid Based Complement Alternat Med |
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Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. |
2012 |
Mol Med Rep |
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Mol. Pharm. |
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2012 |
Biochem. Biophys. Res. Commun. |
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Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. |
2013 |
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Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. |
2012 |
Discov Med |
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Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. |
2013 |
Phytomedicine |
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Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. |
2013 |
Toxicology |
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Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. |
2012 |
PLoS ONE |
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Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. |
2013 |
Int. J. Oncol. |
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Yeh CH et al. |
Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. |
2014 |
Environ. Toxicol. |
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Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. |
2013 |
Apoptosis |
pmid:23371323
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Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. |
2014 |
Phytother Res |
pmid:23463646
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Yeh CH et al. |
Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. |
2015 |
Toxicol Ind Health |
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Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. |
2014 |
Clin Nutr |
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Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. |
2013 |
Toxicol. Appl. Pharmacol. |
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Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. |
2013 |
Pharm Biol |
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Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. |
2014 |
Mol. Carcinog. |
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Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. |
2013 |
Planta Med. |
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V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. |
2014 |
Arch. Toxicol. |
pmid:23835921
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Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. |
2013 |
Biochem. Cell Biol. |
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Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. |
2013 |
Food Chem. Toxicol. |
pmid:23872129
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GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. |
2013 |
Toxicol. Lett. |
pmid:23872260
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He L et al. |
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. |
2013 |
Toxicology |
pmid:23907061
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Kim MS et al. |
Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. |
2013 |
Cell Biol. Toxicol. |
pmid:23955116
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Chirumbolo S |
Anticancer properties of the flavone wogonin. |
2013 |
Toxicology |
pmid:23994129
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The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. |
2013 |
J Pharm Sci |
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Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis. |
2014 |
Fitoterapia |
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Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. |
2014 |
Pharm Biol |
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Wogonin influences vascular permeability via Wnt/β-catenin pathway. |
2015 |
Mol. Carcinog. |
pmid:24136474
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Fong SY and Zuo Z |
Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. |
2014 |
Xenobiotica |
pmid:24168065
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A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. |
2014 |
Drug Deliv |
pmid:24215357
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Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. |
2013 |
Afr Health Sci |
pmid:24250287
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Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. |
2013 |
PLoS ONE |
pmid:24265759
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Lin CC et al. |
Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. |
2013 Nov-Dec |
In Vivo |
pmid:24292576
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Screening of osteoanagenesis-active compounds from Scutellaria baicalensis Georgi by hPDLC/CMC-online-HPLC/MS. |
2014 |
Fitoterapia |
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[Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. |
2013 |
Sichuan Da Xue Xue Bao Yi Xue Ban |
pmid:24490490
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Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway. |
2014 |
Vascul. Pharmacol. |
pmid:24534483
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Zhang F and Wang G |
A review of non-nucleoside anti-hepatitis B virus agents. |
2014 |
Eur J Med Chem |
pmid:24549242
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Shin HS et al. |
Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. |
2014 |
Molecules |
pmid:24566319
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Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro. |
2014 |
Int. J. Oncol. |
pmid:24604573
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Qian C et al. |
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells. |
2014 |
Free Radic. Res. |
pmid:24666416
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Yao J et al. |
Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. |
2014 |
Immunology |
pmid:24766487
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Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. |
2014 |
Molecules |
pmid:24786691
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Fong SY et al. |
Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. |
2014 |
J Pharm Biomed Anal |
pmid:24803030
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Zhao K et al. |
Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling. |
2014 |
Eur. J. Pharmacol. |
pmid:24858369
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Polier G et al. |
Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263. |
2015 |
Int. J. Cancer |
pmid:24895203
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Yao J et al. |
NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. |
2014 |
Cell Death Dis |
pmid:24901054
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Zhao Y et al. |
Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. |
2015 |
Mol. Carcinog. |
pmid:24976450
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Ku SK and Bae JS |
Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. |
2014 |
Fitoterapia |
pmid:25020199
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The role of wogonin in controlling SOCS3 expression in neuronal cells. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:25035930
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Huang KF et al. |
[Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells]. |
2014 |
Zhongguo Zhong Yao Za Zhi |
pmid:25039187
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Yang H et al. |
Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. |
2014 |
Oncotarget |
pmid:25149543
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Hosseinzadeh Z et al. |
Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:25168590
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Zhao K et al. |
Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. |
2014 |
PLoS ONE |
pmid:25203554
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Kwak S et al. |
Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. |
2014 |
Toxicol. Appl. Pharmacol. |
pmid:25223693
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Marsh Z et al. |
Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. |
2014 |
Phytochemistry |
pmid:25236693
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Lee W et al. |
Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo. |
2015 |
Inflammation |
pmid:25249339
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Xu X et al. |
Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway. |
2014 |
Biochem. Pharmacol. |
pmid:25264278
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Xiao JR et al. |
Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. |
2014 |
J Ocul Pharmacol Ther |
pmid:25280175
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Xu S et al. |
Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25381475
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Aslan E and Adem S |
In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. |
2015 |
J. Biochem. Mol. Toxicol. |
pmid:25388478
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Chen F et al. |
Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. |
2015 |
J. Mol. Neurosci. |
pmid:25417142
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Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix. |
2015 |
Nat. Prod. Res. |
pmid:25427178
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Yan T et al. |
Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. |
2014 |
Diagn Pathol |
pmid:25432585
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Chen S et al. |
Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25504431
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Boozari M et al. |
Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. |
2015 |
Environ. Toxicol. Pharmacol. |
pmid:25546119
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Ku SK et al. |
Inhibitory effect of baicalin, baicalein and wogonin on secretory group IIA phospholipase A2. |
2015 |
Arch. Pharm. Res. |
pmid:25564337
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Zhu Y and Wang J |
Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer's disease. |
2015 |
Neurol. Sci. |
pmid:25596147
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Lucas CD et al. |
Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation. |
2015 |
Am. J. Respir. Crit. Care Med. |
pmid:25629436
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Tan CX et al. |
Activities of wogonin analogs and other flavones against Flavobacterium columnare. |
2015 |
Chem. Biodivers. |
pmid:25676507
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Dong LL et al. |
An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. |
2012 |
Food Chem |
pmid:25683416
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Ku SK and Bae JS |
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo. |
2015 |
BMB Rep |
pmid:25739393
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Ge W et al. |
Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway. |
2015 |
J. Mol. Neurosci. |
pmid:25740014
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Persson C |
Drug-induced death of eosinophils. Promises and pitfalls. |
2015 |
Am. J. Respir. Crit. Care Med. |
pmid:25767918
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Hu C et al. |
Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway. |
2015 |
Oncol. Rep. |
pmid:25846394
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Lee JY and Park W |
Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. |
2015 |
Molecules |
pmid:25913928
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Wang W et al. |
Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro. |
2015 |
Inflamm. Res. |
pmid:25917044
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Zhao L et al. |
LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells. |
2016 |
Mol. Carcinog. |
pmid:25945460
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Huang Y et al. |
Wogonin inhibits LPS-induced vascular permeability via suppressing MLCK/MLC pathway. |
2015 |
Vascul. Pharmacol. |
pmid:25956732
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Xiao W et al. |
Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity. |
2015 |
J. Immunother. |
pmid:25962106
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Zhang YM et al. |
Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. |
2015 |
Acta Pharmacol. Sin. |
pmid:26073326
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Sun HL et al. |
Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α. |
2016 |
Environ. Toxicol. |
pmid:26213241
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Liu J et al. |
Deep Sequencing of the Scutellaria baicalensis Georgi Transcriptome Reveals Flavonoid Biosynthetic Profiling and Organ-Specific Gene Expression. |
2015 |
PLoS ONE |
pmid:26317778
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