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A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. |
2012 |
Mol. Pharm. |
pmid:23033922
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Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. |
2012 |
Int J Mol Sci |
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Im AR et al. |
Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. |
2012 |
Evid Based Complement Alternat Med |
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Li Y and Martin RC |
Herbal medicine and hepatocellular carcinoma: applications and challenges. |
2011 |
Evid Based Complement Alternat Med |
pmid:21799681
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Kim EJ et al. |
Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel. |
2011 |
Acta Physiol (Oxf) |
pmid:21306568
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Shia CS et al. |
Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity. |
2011 |
Evid Based Complement Alternat Med |
pmid:19737807
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Chen CM et al. |
Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats. |
2011 |
Evid Based Complement Alternat Med |
pmid:19584080
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Shih YT et al. |
San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells. |
2011 |
Evid Based Complement Alternat Med |
pmid:19339484
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Liu YM et al. |
Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. |
2011 |
Acta Pharmacol. Sin. |
pmid:21986573
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Shi R et al. |
Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. |
2011 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:21514902
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Chen S et al. |
Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. |
2011 |
Cell Biol. Toxicol. |
pmid:20872277
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Li C et al. |
Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. |
2011 |
J Pharm Biomed Anal |
pmid:21051171
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Lim H et al. |
Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. |
2011 |
J. Pharmacol. Sci. |
pmid:21606625
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Ahn SH et al. |
Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. |
2011 |
BMC Neurosci |
pmid:21810275
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Mazzio EA et al. |
The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. |
2011 |
Int J Mol Sci |
pmid:21340000
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Gao J et al. |
The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. |
2011 |
Toxicol. Appl. Pharmacol. |
pmid:21457722
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Park NI et al. |
Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. |
2011 |
Funct. Integr. Genomics |
pmid:21538138
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Yang C et al. |
Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. |
2011 |
PLoS ONE |
pmid:21779360
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Han S et al. |
Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. |
2011 |
Nutr Res Pract |
pmid:21779522
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Tan W et al. |
Anti-cancer natural products isolated from chinese medicinal herbs. |
2011 |
Chin Med |
pmid:21777476
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Lin B |
Polyphenols and neuroprotection against ischemia and neurodegeneration. |
2011 |
Mini Rev Med Chem |
pmid:22070681
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Gasiorowski K et al. |
Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? |
2011 |
CNS Neurol Disord Drug Targets |
pmid:21222632
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Li C et al. |
Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. |
2011 |
Biopharm Drug Dispos |
pmid:21928297
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Chen CY et al. |
Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae. |
2011 |
Am. J. Chin. Med. |
pmid:21905290
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Zeng H et al. |
The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway. |
2011 |
J Ethnopharmacol |
pmid:21466840
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Xie S et al. |
Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9. |
2011 |
J. Pharm. Pharmacol. |
pmid:21235595
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Chen J et al. |
Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study. |
2011 |
Biomed. Chromatogr. |
pmid:21154891
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Zan B et al. |
Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. |
2011 |
Biomed. Chromatogr. |
pmid:20872909
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Kimura Y and Sumiyoshi M |
Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. |
2011 |
Eur. J. Pharmacol. |
pmid:21549115
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Takahashi H et al. |
Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. |
2011 |
Biochim. Biophys. Acta |
pmid:21596068
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Yang DZ et al. |
Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. |
2011 |
Talanta |
pmid:21726714
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Li T et al. |
Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. |
2011 |
Eur J Drug Metab Pharmacokinet |
pmid:21713461
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Lee YM et al. |
Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. |
2011 |
J. Cardiovasc. Pharmacol. |
pmid:21436723
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Yu JS and Kim AK |
Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. |
2011 |
Mol. Cells |
pmid:21448585
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Zhao L et al. |
Developmental toxicity and genotoxicity studies of wogonin. |
2011 |
Regul. Toxicol. Pharmacol. |
pmid:21459121
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Chen P et al. |
Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. |
2011 |
Toxicology |
pmid:21295103
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Yang L et al. |
Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. |
2011 |
Cancer Sci. |
pmid:21244577
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Chow SE et al. |
Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:21207227
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Chen CY et al. |
Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. |
2011 |
J. Nutr. Biochem. |
pmid:21190831
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Lin CC et al. |
Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. |
2011 |
Int. J. Oncol. |
pmid:21573491
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Messaoudene D et al. |
Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease. |
2011 |
J Inflamm (Lond) |
pmid:22104639
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Jeong JC et al. |
Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. |
2011 |
J. Exp. Clin. Cancer Res. |
pmid:21501525
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Tang H et al. |
The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. |
2011 |
BMC Biol. |
pmid:21418589
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Parajuli P et al. |
Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. |
2011 |
J. Neurooncol. |
pmid:20467782
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Chen FP et al. |
Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002. |
2011 |
Evid Based Complement Alternat Med |
pmid:19339485
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Tayarani-Najaran Z et al. |
Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. |
2011 |
Evid Based Complement Alternat Med |
pmid:20028719
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Enomoto R et al. |
Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:20658136
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Calvo TR et al. |
Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts. |
2011 |
Evid Based Complement Alternat Med |
pmid:19696193
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Wu B et al. |
Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. |
2011 |
BMC Cancer |
pmid:22204275
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Dong P et al. |
Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. |
2011 |
J Ethnopharmacol |
pmid:21855619
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Polier G et al. |
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. |
2011 |
Cell Death Dis |
pmid:21776020
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Pan SY et al. |
New perspectives on chinese herbal medicine (zhong-yao) research and development. |
2011 |
Evid Based Complement Alternat Med |
pmid:21785622
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Su SY and Hsieh CL |
Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. |
2011 |
Chin Med |
pmid:21740583
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Petraglia AL et al. |
Stuck at the bench: Potential natural neuroprotective compounds for concussion. |
2011 |
Surg Neurol Int |
pmid:22059141
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Samarghandian S et al. |
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
pmid:21808878
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Hou YC et al. |
Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. |
2011 |
Planta Med. |
pmid:20957598
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Lee MY et al. |
A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats. |
2011 |
Toxicol Int |
pmid:21976821
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Katrahalli U et al. |
Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods. |
2010 Oct-Dec |
Sci Pharm |
pmid:21179322
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Hung CW et al. |
Stem cell-based neuroprotective and neurorestorative strategies. |
2010 |
Int J Mol Sci |
pmid:20559500
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Lin CW et al. |
12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression. |
2010 |
J. Cell. Physiol. |
pmid:20458747
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Jeong HJ et al. |
Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. |
2010 |
J Neuroinflammation |
pmid:21108840
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Ni Y et al. |
Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches. |
2010 |
Anal. Chim. Acta |
pmid:20206002
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Jang S et al. |
Wogonin inhibits osteoclast formation induced by lipopolysaccharide. |
2010 |
Phytother Res |
pmid:19998398
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Meng X et al. |
Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. |
2010 |
Parkinsons Dis |
pmid:20976092
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Zhou Q et al. |
Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. |
2010 |
Pharm. Res. |
pmid:20411407
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Khoo BY et al. |
Apoptotic effects of chrysin in human cancer cell lines. |
2010 |
Int J Mol Sci |
pmid:20559509
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Kunwar RM et al. |
Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. |
2010 |
J Ethnobiol Ethnomed |
pmid:21144003
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Wang CZ et al. |
Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. |
2010 |
Phytomedicine |
pmid:19836937
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Ye G et al. |
Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry. |
2010 |
Chem. Biodivers. |
pmid:21162005
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Tilton R et al. |
A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. |
2010 |
Chin Med |
pmid:20727161
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Li Y et al. |
Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers. |
2010 |
J Pharm Biomed Anal |
pmid:20138726
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Liang X et al. |
Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry. |
2010 |
J Pharm Biomed Anal |
pmid:19783115
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Wei L et al. |
Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. |
2010 |
J. Cell. Biochem. |
pmid:21053277
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Lim JS et al. |
Wogonin induces differentiation and neurite outgrowth of neural precursor cells. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20888794
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Lei W et al. |
Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. |
2010 |
Genet. Mol. Biol. |
pmid:21637484
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Huang ST et al. |
Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. |
2010 |
Phytomedicine |
pmid:19577445
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Ijaz AZ et al. |
MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge. |
2010 |
BMC Bioinformatics |
pmid:20406501
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Cui X et al. |
Traditional Chinese medicine and related active compounds against hepatitis B virus infection. |
2010 |
Biosci Trends |
pmid:20448340
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Ozmen A et al. |
In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. |
2010 |
Phytomedicine |
pmid:19576743
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Zhao Q et al. |
Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. |
2010 |
Toxicol. Lett. |
pmid:20570612
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Xu H et al. |
Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. |
2010 |
Bioresour. Technol. |
pmid:20708926
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Ishii K et al. |
Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. |
2010 |
Cancer Invest. |
pmid:19863351
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Schrader KK |
Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). |
2010 |
Toxins (Basel) |
pmid:22069655
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Gao J et al. |
Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. |
2010 |
J Pharm Biomed Anal |
pmid:20457505
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Feng J et al. |
Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. |
2010 |
J Pharm Biomed Anal |
pmid:20430560
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You J et al. |
On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. |
2010 |
J Chromatogr A |
pmid:20138285
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Kong EK et al. |
Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. |
2010 |
BMB Rep |
pmid:20423617
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Lu B et al. |
Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. |
2009 Sep-Oct |
Phytochem Anal |
pmid:19533595
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Kaneko T et al. |
Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage. |
2009 Jul-Aug |
In Vivo |
pmid:19567393
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Yin L et al. |
Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control. |
2009 |
J Pharm Biomed Anal |
pmid:19264437
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Cao H et al. |
Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. |
2009 |
J. Hazard. Mater. |
pmid:19577841
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Ding XF et al. |
[Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy]. |
2009 |
Guang Pu Xue Yu Guang Pu Fen Xi |
pmid:19650472
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Li C et al. |
Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix Scutellariae. |
2009 |
J Pharm Biomed Anal |
pmid:19481403
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Rushworth SA and Micheau O |
Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. |
2009 |
Br. J. Pharmacol. |
pmid:19664138
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Peng J et al. |
Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. |
2009 |
J Ethnopharmacol |
pmid:19397969
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Lee DH et al. |
Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. |
2009 |
Br. J. Pharmacol. |
pmid:19438509
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Yang L et al. |
Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. |
2009 |
Biochem. Cell Biol. |
pmid:19935879
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Li J et al. |
Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. |
2009 |
J. Nat. Prod. |
pmid:19555121
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Inhibition of prostaglandin E2 production by synthetic wogonin analogs. |
2009 |
Arch. Pharm. Res. |
pmid:20091262
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Kim HS et al. |
Cloning and expression of beta-glucuronidase from Lactobacillus brevis in E. coli and application in the bioconversion of baicalin and wogonoside. |
2009 |
J. Microbiol. Biotechnol. |
pmid:20075633
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