Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Acute Lung Injury D055371 33 associated lipids
Papillomavirus Infections D030361 4 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Translocation, Genetic D014178 20 associated lipids
Sarcoma 180 D012510 21 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Penile Induration D010411 4 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
Hämäläinen M et al. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. 2007 Mediators Inflamm. pmid:18274639
Kim YH et al. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. 2007 Arch. Pharm. Res. pmid:17366750
Ohta Y et al. Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue. 2007 J Clin Biochem Nutr pmid:18437211
Hsieh CJ et al. Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. 2007 Clin Mol Allergy pmid:18039391
Huang GC et al. Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. 2007 Int. Immunopharmacol. pmid:17570322
Qu H et al. Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography. 2007 J Pharm Biomed Anal pmid:16846714
Yu K et al. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis. 2007 J Pharm Biomed Anal pmid:16989969
Yu JQ et al. Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells. 2007 Hepatol. Res. pmid:17300700
Enomoto R et al. Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. 2007 J. Pharmacol. Sci. pmid:17690528
Park HG et al. Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. 2007 Eur. J. Pharmacol. pmid:17692312
Tang NY et al. Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats. 2006 Jul-Aug In Vivo pmid:16900784
Lin CM et al. Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1. 2006 Int. Immunopharmacol. pmid:16979123
Wang W et al. Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. 2006 Anticancer Drugs pmid:16926629
Fas SC et al. Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. 2006 Blood pmid:16931628
Lin CM et al. Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2. 2006 Planta Med. pmid:17024605
Lee SO et al. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. 2006 Biochem. Biophys. Res. Commun. pmid:17052690
Wang W et al. The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo. 2006 Biol. Pharm. Bull. pmid:16755005
Feng YL et al. [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography]. 2006 Yao Xue Xue Bao pmid:16759005
Chang WT et al. Cardioprotective effects of grape seed proanthocyanidins, baicalin and wogonin: comparison between acute and chronic treatments. 2006 Am. J. Chin. Med. pmid:16700106
Shen SC et al. Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids. 2006 Neuroscience pmid:16580779
Adams LS et al. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. 2006 Evid Based Complement Alternat Med pmid:16550232
Pan MH et al. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. 2006 Biochem. Pharmacol. pmid:16949556
Chang LC and Sun SW Micellar electrokinetic chromatography for separation of a mixture of coptis alkaloids, scute flavonoids, and rhubarb anthraquinones and bianthrones. 2006 J Pharm Biomed Anal pmid:16297588
Hu Y et al. Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. 2006 Biochem. Biophys. Res. Commun. pmid:17069758
Huang WH et al. Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. 2006 Biosci. Biotechnol. Biochem. pmid:17031041
Zhang H et al. Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive. 2006 J Chromatogr A pmid:16952364
Zgórka G Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus. 2006 J Chromatogr A pmid:16364344
Kim YH et al. Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma. 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16893689
Zhao Y et al. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. 2006 Eur. J. Pharmacol. pmid:16574098
Yu CS et al. Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells. 2005 Jan-Feb Anticancer Res. pmid:15816529
Tian J et al. Interaction of wogonin with bovine serum albumin. 2005 Bioorg. Med. Chem. pmid:15911327
Chuang HN et al. Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line. 2005 Planta Med. pmid:15931583
Tai MC et al. Therapeutic potential of wogonin: a naturally occurring flavonoid. 2005 CNS Drug Rev pmid:16007236
Li C et al. Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. 2005 Biomed. Chromatogr. pmid:15627280
Yoon JH and Baek SJ Molecular targets of dietary polyphenols with anti-inflammatory properties. 2005 Yonsei Med. J. pmid:16259055
Aung H et al. Scutellaria baicalensis decreases ritonavir-induced nausea. 2005 AIDS Res Ther pmid:16368007
Dao TT et al. Synthesis and iNOS inhibitory activities of thioflavones. 2005 Arch. Pharm. Res. pmid:16042072
Hardeland R and Pandi-Perumal SR Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug. 2005 Nutr Metab (Lond) pmid:16153306
Bonham M et al. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. 2005 Clin. Cancer Res. pmid:15897592
Park H et al. Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. 2005 Eur J Med Chem pmid:15963606
Park EJ et al. Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells. 2005 Planta Med. pmid:16206047
Jang J et al. Structure and antiinflammatory activity relationships of wogonin derivatives. 2005 Arch. Pharm. Res. pmid:16178410
Han CK et al. Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism. 2005 Biol. Pharm. Bull. pmid:16079475
Ma Z et al. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. 2005 Blood pmid:15626742
Goh D et al. Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. 2005 J. Agric. Food Chem. pmid:16218664
Li HB and Chen F Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. 2005 J Chromatogr A pmid:15941045
Ohtake N et al. The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. 2005 Eur. J. Pharmacol. pmid:15659321
Chun W et al. Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity. 2005 Arch. Pharm. Res. pmid:15789754
Chi YS and Kim HP Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15589400
Liu Y et al. Binding of wogonin to human gammaglobulin. 2005 Int. J. Biol. Macromol. pmid:16242767