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Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. |
2012 |
PLoS ONE |
pmid:22272328
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Xia Y et al. |
A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. |
2012 |
J Pharm Biomed Anal |
pmid:22906689
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Shao YX et al. |
The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. |
2012 |
Eur. Biophys. J. |
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Zhu Y et al. |
Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry. |
2012 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Dong LL et al. |
An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. |
2012 |
Food Chem |
pmid:25683416
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Chen SS et al. |
Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. |
2012 |
Discov Med |
pmid:22284780
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Li X et al. |
Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. |
2012 |
Evid Based Complement Alternat Med |
pmid:22235229
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Chow SE et al. |
Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. |
2012 |
J. Cell. Biochem. |
pmid:22689083
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Toton E et al. |
The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. |
2012 |
Eur. J. Pharmacol. |
pmid:22381066
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Tong L et al. |
Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. |
2012 |
J Pharm Biomed Anal |
pmid:22703838
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Pham TA et al. |
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. |
2012 |
Bioorg. Med. Chem. Lett. |
pmid:22366656
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Ha SK et al. |
6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. |
2012 |
Neuropharmacology |
pmid:22465818
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Chen S et al. |
Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:23063682
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Li Y et al. |
Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:22560901
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Li WJ et al. |
Phenolic compounds and antioxidant activities of Liriope muscari. |
2012 |
Molecules |
pmid:22328078
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Matsunaga T et al. |
Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. |
2012 |
Front Pharmacol |
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Ho FM et al. |
Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. |
2012 |
J Ethnopharmacol |
pmid:22543166
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Wilczańska-Barska A et al. |
Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. |
2012 |
Biotechnol. Lett. |
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He H et al. |
Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. |
2012 |
J Pharm Biomed Anal |
pmid:22260968
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Islam MN et al. |
A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. |
2012 |
Nat. Prod. Res. |
pmid:22304335
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Dandawate S et al. |
Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. |
2012 |
Cancer Immunol. Immunother. |
pmid:22057676
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Eylenstein A et al. |
Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. |
2012 |
J. Biol. Chem. |
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Cao XD et al. |
Antitumor constituents from the leaves of Carya cathayensis. |
2012 |
Nat. Prod. Res. |
pmid:22007794
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Lu QY et al. |
Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. |
2012 |
Pancreas |
pmid:22158070
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Li C et al. |
Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. |
2012 |
AAPS J |
pmid:22167378
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Chi DS et al. |
Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. |
2012 |
Clin Mol Allergy |
pmid:22309647
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Kim JO et al. |
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. |
2012 |
Phytother Res |
pmid:22388989
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Zhang N et al. |
A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. |
2012 |
Evid Based Complement Alternat Med |
pmid:22272213
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Zhong Y et al. |
Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. |
2013 |
Mol. Carcinog. |
pmid:22593043
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Xu F et al. |
The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. |
2013 |
J Pharm Sci |
pmid:24018852
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Oshima N et al. |
Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. |
2013 |
J Nat Med |
pmid:22729955
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Yu C et al. |
Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. |
2013 |
Pharm Biol |
pmid:23738852
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Wang Y et al. |
GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. |
2013 |
Toxicol. Lett. |
pmid:23872260
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Zhao L et al. |
Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. |
2013 |
Biochem. Cell Biol. |
pmid:23859016
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Wang F et al. |
Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. |
2013 |
Toxicology |
pmid:23246481
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Kimura Y and Sumiyoshi M |
Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. |
2013 |
Phytomedicine |
pmid:23219337
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Wang CZ et al. |
Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. |
2013 |
Int. J. Oncol. |
pmid:23337959
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Yang L et al. |
Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. |
2013 |
Apoptosis |
pmid:23371323
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Song X et al. |
Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. |
2013 |
Toxicol. Appl. Pharmacol. |
pmid:23707765
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Zhang M et al. |
Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. |
2013 |
Life Sci. |
pmid:23142241
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Chengcheng G et al. |
Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. |
2013 |
Afr Health Sci |
pmid:24250287
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Chen XM et al. |
Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. |
2013 |
PLoS ONE |
pmid:24265759
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He L et al. |
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. |
2013 |
Toxicology |
pmid:23907061
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Chirumbolo S |
Anticancer properties of the flavone wogonin. |
2013 |
Toxicology |
pmid:23994129
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Zhou YQ et al. |
[Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. |
2013 |
Sichuan Da Xue Xue Bao Yi Xue Ban |
pmid:24490490
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Kim MS et al. |
Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. |
2013 |
Cell Biol. Toxicol. |
pmid:23955116
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Attia SM et al. |
Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. |
2013 |
Food Chem. Toxicol. |
pmid:23872129
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Kim SG et al. |
Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas. |
2013 |
J Nat Med |
pmid:22855402
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Kim TW et al. |
Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. |
2013 |
Planta Med. |
pmid:23818268
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Lin CC et al. |
Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. |
2013 Nov-Dec |
In Vivo |
pmid:24292576
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Xiao JR et al. |
Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. |
2014 |
J Ocul Pharmacol Ther |
pmid:25280175
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Kwak S et al. |
Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. |
2014 |
Toxicol. Appl. Pharmacol. |
pmid:25223693
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Li C et al. |
Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. |
2014 |
Pharm Biol |
pmid:24102566
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Fong SY et al. |
Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. |
2014 |
J Pharm Biomed Anal |
pmid:24803030
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Sikder MA et al. |
Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. |
2014 |
Phytother Res |
pmid:23463646
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Bak EJ et al. |
Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. |
2014 |
Clin Nutr |
pmid:23623334
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Liu J et al. |
Screening of osteoanagenesis-active compounds from Scutellaria baicalensis Georgi by hPDLC/CMC-online-HPLC/MS. |
2014 |
Fitoterapia |
pmid:24393619
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Fong SY and Zuo Z |
Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. |
2014 |
Xenobiotica |
pmid:24168065
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Gong WY et al. |
Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro. |
2014 |
Int. J. Oncol. |
pmid:24604573
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Wang H et al. |
Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. |
2014 |
Mol. Carcinog. |
pmid:23761018
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Huang KF et al. |
[Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells]. |
2014 |
Zhongguo Zhong Yao Za Zhi |
pmid:25039187
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Shin HS et al. |
Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. |
2014 |
Molecules |
pmid:24566319
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Yeh CH et al. |
Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. |
2014 |
Environ. Toxicol. |
pmid:23362215
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Nam KW et al. |
The role of wogonin in controlling SOCS3 expression in neuronal cells. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:25035930
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Zhang F and Wang G |
A review of non-nucleoside anti-hepatitis B virus agents. |
2014 |
Eur J Med Chem |
pmid:24549242
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Yao J et al. |
Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. |
2014 |
Immunology |
pmid:24766487
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Zhang Y et al. |
V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. |
2014 |
Arch. Toxicol. |
pmid:23835921
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Marsh Z et al. |
Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. |
2014 |
Phytochemistry |
pmid:25236693
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Tian SS et al. |
Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis. |
2014 |
Fitoterapia |
pmid:24096161
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Yan T et al. |
Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. |
2014 |
Diagn Pathol |
pmid:25432585
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Zhao K et al. |
Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. |
2014 |
PLoS ONE |
pmid:25203554
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Yang H et al. |
Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. |
2014 |
Oncotarget |
pmid:25149543
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Yao J et al. |
NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. |
2014 |
Cell Death Dis |
pmid:24901054
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Talbi A et al. |
Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. |
2014 |
Molecules |
pmid:24786691
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Xu X et al. |
Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway. |
2014 |
Biochem. Pharmacol. |
pmid:25264278
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Hosseinzadeh Z et al. |
Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:25168590
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Ku SK and Bae JS |
Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. |
2014 |
Fitoterapia |
pmid:25020199
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Zhao K et al. |
Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling. |
2014 |
Eur. J. Pharmacol. |
pmid:24858369
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Qian C et al. |
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells. |
2014 |
Free Radic. Res. |
pmid:24666416
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Zhou M et al. |
Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway. |
2014 |
Vascul. Pharmacol. |
pmid:24534483
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Tian J et al. |
A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. |
2014 |
Drug Deliv |
pmid:24215357
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Woźniak D et al. |
Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix. |
2015 |
Nat. Prod. Res. |
pmid:25427178
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Lee W et al. |
Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo. |
2015 |
Inflammation |
pmid:25249339
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Ku SK and Bae JS |
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo. |
2015 |
BMB Rep |
pmid:25739393
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Aslan E and Adem S |
In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. |
2015 |
J. Biochem. Mol. Toxicol. |
pmid:25388478
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Zhang YM et al. |
Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. |
2015 |
Acta Pharmacol. Sin. |
pmid:26073326
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Lee JY and Park W |
Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. |
2015 |
Molecules |
pmid:25913928
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Lucas CD et al. |
Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation. |
2015 |
Am. J. Respir. Crit. Care Med. |
pmid:25629436
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Polier G et al. |
Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263. |
2015 |
Int. J. Cancer |
pmid:24895203
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Xiao W et al. |
Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity. |
2015 |
J. Immunother. |
pmid:25962106
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Huang Y et al. |
Wogonin inhibits LPS-induced vascular permeability via suppressing MLCK/MLC pathway. |
2015 |
Vascul. Pharmacol. |
pmid:25956732
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Wang W et al. |
Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro. |
2015 |
Inflamm. Res. |
pmid:25917044
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Hu C et al. |
Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway. |
2015 |
Oncol. Rep. |
pmid:25846394
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Persson C |
Drug-induced death of eosinophils. Promises and pitfalls. |
2015 |
Am. J. Respir. Crit. Care Med. |
pmid:25767918
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Chen S et al. |
Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25504431
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Chen F et al. |
Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. |
2015 |
J. Mol. Neurosci. |
pmid:25417142
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Xu S et al. |
Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25381475
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Zhao Y et al. |
Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. |
2015 |
Mol. Carcinog. |
pmid:24976450
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Song X et al. |
Wogonin influences vascular permeability via Wnt/β-catenin pathway. |
2015 |
Mol. Carcinog. |
pmid:24136474
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Yeh CH et al. |
Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. |
2015 |
Toxicol Ind Health |
pmid:23592745
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