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The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. |
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Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. |
2012 |
Cancer Immunol. Immunother. |
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Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. |
2012 |
Phytother Res |
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Li Y and Martin RC |
Herbal medicine and hepatocellular carcinoma: applications and challenges. |
2011 |
Evid Based Complement Alternat Med |
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Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel. |
2011 |
Acta Physiol (Oxf) |
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Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity. |
2011 |
Evid Based Complement Alternat Med |
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Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats. |
2011 |
Evid Based Complement Alternat Med |
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San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells. |
2011 |
Evid Based Complement Alternat Med |
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Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. |
2011 |
Acta Pharmacol. Sin. |
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Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. |
2011 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. |
2011 |
Cell Biol. Toxicol. |
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Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. |
2011 |
J Pharm Biomed Anal |
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Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. |
2011 |
J. Pharmacol. Sci. |
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Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. |
2011 |
BMC Neurosci |
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The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. |
2011 |
Toxicol. Appl. Pharmacol. |
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Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. |
2011 |
Funct. Integr. Genomics |
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Anti-cancer natural products isolated from chinese medicinal herbs. |
2011 |
Chin Med |
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Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? |
2011 |
CNS Neurol Disord Drug Targets |
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Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. |
2011 |
Biopharm Drug Dispos |
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Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae. |
2011 |
Am. J. Chin. Med. |
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The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway. |
2011 |
J Ethnopharmacol |
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2011 |
J. Pharm. Pharmacol. |
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Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study. |
2011 |
Biomed. Chromatogr. |
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Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. |
2011 |
Biomed. Chromatogr. |
pmid:20872909
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Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. |
2011 |
Eur. J. Pharmacol. |
pmid:21549115
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Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. |
2011 |
Biochim. Biophys. Acta |
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Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. |
2011 |
Talanta |
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Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. |
2011 |
Eur J Drug Metab Pharmacokinet |
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Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. |
2011 |
J. Cardiovasc. Pharmacol. |
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Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. |
2011 |
Mol. Cells |
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Developmental toxicity and genotoxicity studies of wogonin. |
2011 |
Regul. Toxicol. Pharmacol. |
pmid:21459121
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Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. |
2011 |
Toxicology |
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Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. |
2011 |
Cancer Sci. |
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Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:21207227
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Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. |
2011 |
J. Nutr. Biochem. |
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Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. |
2011 |
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Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease. |
2011 |
J Inflamm (Lond) |
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Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. |
2011 |
J. Exp. Clin. Cancer Res. |
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Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002. |
2011 |
Evid Based Complement Alternat Med |
pmid:19339485
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Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. |
2011 |
Evid Based Complement Alternat Med |
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Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts. |
2011 |
Evid Based Complement Alternat Med |
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Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. |
2011 |
BMC Cancer |
pmid:22204275
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Dong P et al. |
Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. |
2011 |
J Ethnopharmacol |
pmid:21855619
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Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. |
2011 |
Cell Death Dis |
pmid:21776020
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New perspectives on chinese herbal medicine (zhong-yao) research and development. |
2011 |
Evid Based Complement Alternat Med |
pmid:21785622
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Su SY and Hsieh CL |
Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. |
2011 |
Chin Med |
pmid:21740583
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Stuck at the bench: Potential natural neuroprotective compounds for concussion. |
2011 |
Surg Neurol Int |
pmid:22059141
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Samarghandian S et al. |
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
pmid:21808878
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Hou YC et al. |
Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. |
2011 |
Planta Med. |
pmid:20957598
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Lee MY et al. |
A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats. |
2011 |
Toxicol Int |
pmid:21976821
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