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Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis. |
2018 |
Mol Plant |
pmid:28842248
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Hong M et al. |
Wogonin Suppresses the Activity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion in Human Hepatocellular Carcinoma. |
2018 |
Molecules |
pmid:29439451
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Hong ZP et al. |
Wogonin exacerbates the cytotoxic effect of oxaliplatin by inducing nitrosative stress and autophagy in human gastric cancer cells. |
2018 |
Phytomedicine |
pmid:29433678
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Shimizu T et al. |
Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-κB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids. |
2018 |
J Nat Med |
pmid:28921127
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Sukkar B et al. |
Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin. |
2018 |
Cell. Physiol. Biochem. |
pmid:30453283
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Wang CZ et al. |
Deglycosylation of wogonoside enhances its anticancer potential. |
2018 |
J Cancer Res Ther |
pmid:30249874
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Go JH et al. |
Wogonin suppresses the LPS‑enhanced invasiveness of MDA‑MB‑231 breast cancer cells by inhibiting the 5‑LO/BLT2 cascade. |
2018 |
Int. J. Mol. Med. |
pmid:30015917
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Sabra SA et al. |
Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer. |
2018 |
Eur J Pharm Biopharm |
pmid:29689288
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Xu PP et al. |
Wogonin Inhibits Growth of Mantle Cell Lymphoma Cells through Nuclear Factor-κB Signaling Pathway. |
2018 |
Chin. Med. J. |
pmid:29451160
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Meng XM et al. |
Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis. |
2018 |
Lab. Invest. |
pmid:29200200
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Zhao K et al. |
LW-215, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo. |
2018 |
Gene |
pmid:29196258
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Zhang Y et al. |
The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma. |
2018 |
Eur J Drug Metab Pharmacokinet |
pmid:29134502
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Fong SYK et al. |
Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. |
2017 |
Mol. Pharm. |
pmid:28426226
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Yamashita Y et al. |
Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation. |
2017 |
Biosci. Biotechnol. Biochem. |
pmid:28345416
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Wang J et al. |
Mediating macrophage immunity with wogonin in mice with vascular inflammation. |
2017 |
Mol Med Rep |
pmid:28983597
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Protective effects of wogonin against disease progression in different hepatic pathological conditions. |
2017 |
Int. Immunopharmacol. |
pmid:28886583
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Li HD et al. |
Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. |
2017 |
Int. Immunopharmacol. |
pmid:28646664
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Xu X et al. |
Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation. |
2017 |
Sci Rep |
pmid:28150717
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Chen M et al. |
Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. |
2017 |
Biomed. Chromatogr. |
pmid:28236316
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Khan NM et al. |
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes. |
2017 |
Sci Rep |
pmid:28256567
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Ruibin J et al. |
Therapy Effects of Wogonin on Ovarian Cancer Cells. |
2017 |
Biomed Res Int |
pmid:29181409
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Paudel MK et al. |
An overview and comparison of a recombinant antigen-binding fragment and an antigen-binding fragment from a monoclonal antibody against wogonin glucuronide. |
2017 |
J Nat Med |
pmid:28623444
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Chen J et al. |
Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro. |
2017 |
Biomed. Pharmacother. |
pmid:28486193
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Shu Q et al. |
Wogonin induces retinal neuron-like differentiation of bone marrow stem cells by inhibiting Notch-1 signaling. |
2017 |
Oncotarget |
pmid:28415701
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Paudel MK et al. |
The effect of varying the peptide linker length in a single chain variable fragment antibody against wogonin glucuronide. |
2017 |
J. Biotechnol. |
pmid:28392422
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Wu X et al. |
Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway. |
2017 |
BMC Cancer |
pmid:28222771
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Yu H et al. |
Enhancement of solubility and dissolution rate of baicalein, wogonin and oroxylin A extracted from Radix scutellariae. |
2017 |
Int J Pharm |
pmid:28642200
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Khan NM et al. |
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes. |
2017 |
Chem. Biol. Interact. |
pmid:28688942
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Wei CY et al. |
Protective effect of wogonin on endotoxin-induced acute lung injury via reduction of p38 MAPK and JNK phosphorylation. |
2017 |
Environ. Toxicol. |
pmid:26892447
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Huynh DL et al. |
Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression. |
2017 |
BMC Complement Altern Med |
pmid:28606135
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Kudo M et al. |
Bifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport. |
2017 |
PLoS ONE |
pmid:28182699
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Yang T et al. |
Wogonin enhances intracellular adiponectin levels and suppresses adiponectin secretion in 3T3-L1 adipocytes. |
2017 |
Endocr. J. |
pmid:27667474
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Liu RX et al. |
Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. |
2017 |
Chin J Nat Med |
pmid:28284428
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Wang J et al. |
Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro. |
2017 |
Eur J Med Chem |
pmid:28987604
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Xiao W et al. |
High-dose wogonin exacerbates DSS-induced colitis by up-regulating effector T cell function and inhibiting Treg cell. |
2017 |
J. Cell. Mol. Med. |
pmid:27641629
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Salmani JMM et al. |
Development of a new HPLC method for wogonin in rat plasma: Compatibility of standard and test samples. |
2017 |
Acta Pharm |
pmid:28858841
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Al-Maghout T et al. |
P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes. |
2017 |
Cell. Physiol. Biochem. |
pmid:28813704
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Shi G et al. |
Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics. |
2017 |
Acta Biochim. Biophys. Sin. (Shanghai) |
pmid:28338770
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Qin X et al. |
Novel platinum(IV) complexes conjugated with a wogonin derivative as multi-targeted anticancer agents. |
2017 |
Bioorg. Med. Chem. |
pmid:28314511
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Chen F et al. |
Reversal of cisplatin resistance in human gastric cancer cells by a wogonin-conjugated Pt(IV) prodrug via attenuating Casein Kinase 2-mediated Nuclear Factor-κB pathways. |
2017 |
Biochem. Pharmacol. |
pmid:28288821
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Huynh DL et al. |
Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. |
2017 |
Chin J Nat Med |
pmid:28259249
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Khan NM et al. |
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes. |
2017 |
Free Radic. Biol. Med. |
pmid:28237856
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Bian J et al. |
Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents. |
2017 |
Bioorg. Med. Chem. Lett. |
pmid:28117202
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Lee HW et al. |
Potent inhibition of monoamine oxidase A by decursin from Angelica gigas Nakai and by wogonin from Scutellaria baicalensis Georgi. |
2017 |
Int. J. Biol. Macromol. |
pmid:28109809
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Zhao Q et al. |
A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. |
2016 |
Sci Adv |
pmid:27152350
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Sun C et al. |
Rapid Isolation and Determination of Flavones in Biological Samples Using Zinc Complexation Coupled with High-Performance Liquid Chromatography. |
2016 |
Molecules |
pmid:27537870
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Fajol A et al. |
Fibroblast growth factor (Fgf) 23 gene transcription depends on actin cytoskeleton reorganization. |
2016 |
FEBS Lett. |
pmid:26878191
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Huang L et al. |
Application of a new method, orthogonal projection to latent structure (OPLS) combined with principal component analysis (PCA), to screening of prostaglandin E2 production inhibitory flavonoids in Scutellaria Root. |
2016 |
J Nat Med |
pmid:27164908
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Chen G et al. |
Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice. |
2016 |
Oncotarget |
pmid:27557503
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Xu Y et al. |
Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush. |
2016 |
Oncotarget |
pmid:27756890
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Kim EH et al. |
Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer. |
2016 |
Apoptosis |
pmid:27544755
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Huang FM et al. |
BisGMA-induced cytotoxicity and genotoxicity in macrophages are attenuated by wogonin via reduction of intrinsic caspase pathway activation. |
2016 |
Environ. Toxicol. |
pmid:26756871
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Sun HL et al. |
Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α. |
2016 |
Environ. Toxicol. |
pmid:26213241
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Peng MX et al. |
Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin. |
2016 |
Chin. Med. J. |
pmid:27958228
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Zhu N et al. |
Characterization and Bioavailability of Wogonin by Different Administration Routes in Beagles. |
2016 |
Med. Sci. Monit. |
pmid:27744456
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Zhang H et al. |
A Novel Prostate-Specific Membrane-Antigen (PSMA) Targeted Micelle-Encapsulating Wogonin Inhibits Prostate Cancer Cell Proliferation via Inducing Intrinsic Apoptotic Pathway. |
2016 |
Int J Mol Sci |
pmid:27196894
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Fu R et al. |
Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis. |
2016 |
Oncotarget |
pmid:26735336
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Liu X et al. |
Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NF‑κB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling. |
2016 |
Int. J. Mol. Med. |
pmid:27499272
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Ryu NH et al. |
Wogonin inhibits transforming growth factor β1-induced extracellular matrix production via the p38/activator protein 1 signaling pathway in nasal polyp-derived fibroblasts. |
2016 |
Am J Rhinol Allergy |
pmid:27456588
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Huang B et al. |
Apoptosis Induction and Imaging of Cadmium-Telluride Quantum Dots with Wogonin in Multidrug-Resistant Leukemia K562/A02 Cell. |
2016 |
J Nanosci Nanotechnol |
pmid:27455661
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Xu X et al. |
BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin. |
2016 |
Oncotarget |
pmid:27027438
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Khan S et al. |
Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties. |
2016 |
Mol. Cell. Endocrinol. |
pmid:27013352
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Yeh YC et al. |
Acute lung injury induced by lipopolysaccharide is inhibited by wogonin in mice via reduction of Akt phosphorylation and RhoA activation. |
2016 |
J. Pharm. Pharmacol. |
pmid:26749510
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Oche B et al. |
Cryptotanshinone and wogonin up-regulate eNOS in vascular endothelial cells via ERα and down-regulate iNOS in LPS stimulated vascular smooth muscle cells via ERβ. |
2016 |
Arch. Pharm. Res. |
pmid:26481132
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Zhao L et al. |
LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells. |
2016 |
Mol. Carcinog. |
pmid:25945460
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Tu B et al. |
Structure-activity relationship study between baicalein and wogonin by spectrometry, molecular docking and microcalorimetry. |
2016 |
Food Chem |
pmid:27132840
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Seo CS and Shin HK |
HPLC-PDA Method for Simultaneous Determination of Nine Marker Components in Banhasasim-Tang. |
2016 |
J Chromatogr Sci |
pmid:26354947
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Ku SK et al. |
Inhibitory effect of baicalin, baicalein and wogonin on secretory group IIA phospholipase A2. |
2015 |
Arch. Pharm. Res. |
pmid:25564337
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Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix. |
2015 |
Nat. Prod. Res. |
pmid:25427178
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Lee W et al. |
Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo. |
2015 |
Inflammation |
pmid:25249339
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Liu J et al. |
Deep Sequencing of the Scutellaria baicalensis Georgi Transcriptome Reveals Flavonoid Biosynthetic Profiling and Organ-Specific Gene Expression. |
2015 |
PLoS ONE |
pmid:26317778
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Ku SK and Bae JS |
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo. |
2015 |
BMB Rep |
pmid:25739393
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Aslan E and Adem S |
In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. |
2015 |
J. Biochem. Mol. Toxicol. |
pmid:25388478
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Qu JT et al. |
Vasodilatory Effect of Wogonin on the Rat Aorta and Its Mechanism Study. |
2015 |
Biol. Pharm. Bull. |
pmid:26632179
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Lu H et al. |
Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis. |
2015 |
Mol Med Rep |
pmid:26398525
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Zhang YM et al. |
Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. |
2015 |
Acta Pharmacol. Sin. |
pmid:26073326
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Lee JY and Park W |
Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. |
2015 |
Molecules |
pmid:25913928
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Lucas CD et al. |
Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation. |
2015 |
Am. J. Respir. Crit. Care Med. |
pmid:25629436
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Polier G et al. |
Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263. |
2015 |
Int. J. Cancer |
pmid:24895203
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Xiao W et al. |
Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity. |
2015 |
J. Immunother. |
pmid:25962106
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Huang Y et al. |
Wogonin inhibits LPS-induced vascular permeability via suppressing MLCK/MLC pathway. |
2015 |
Vascul. Pharmacol. |
pmid:25956732
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Wang W et al. |
Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro. |
2015 |
Inflamm. Res. |
pmid:25917044
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Hu C et al. |
Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway. |
2015 |
Oncol. Rep. |
pmid:25846394
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Persson C |
Drug-induced death of eosinophils. Promises and pitfalls. |
2015 |
Am. J. Respir. Crit. Care Med. |
pmid:25767918
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Ge W et al. |
Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway. |
2015 |
J. Mol. Neurosci. |
pmid:25740014
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Tan CX et al. |
Activities of wogonin analogs and other flavones against Flavobacterium columnare. |
2015 |
Chem. Biodivers. |
pmid:25676507
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Zhu Y and Wang J |
Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer's disease. |
2015 |
Neurol. Sci. |
pmid:25596147
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Boozari M et al. |
Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. |
2015 |
Environ. Toxicol. Pharmacol. |
pmid:25546119
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Chen S et al. |
Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25504431
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Chen F et al. |
Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. |
2015 |
J. Mol. Neurosci. |
pmid:25417142
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Xu S et al. |
Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25381475
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Zhao Y et al. |
Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. |
2015 |
Mol. Carcinog. |
pmid:24976450
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Song X et al. |
Wogonin influences vascular permeability via Wnt/β-catenin pathway. |
2015 |
Mol. Carcinog. |
pmid:24136474
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Yeh CH et al. |
Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. |
2015 |
Toxicol Ind Health |
pmid:23592745
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Fong SY et al. |
Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. |
2014 |
J Pharm Biomed Anal |
pmid:24803030
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Bak EJ et al. |
Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. |
2014 |
Clin Nutr |
pmid:23623334
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Gong WY et al. |
Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro. |
2014 |
Int. J. Oncol. |
pmid:24604573
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Zhao K et al. |
Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling. |
2014 |
Eur. J. Pharmacol. |
pmid:24858369
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Qian C et al. |
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells. |
2014 |
Free Radic. Res. |
pmid:24666416
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Zhou M et al. |
Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway. |
2014 |
Vascul. Pharmacol. |
pmid:24534483
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