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Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. |
2014 |
J Ocul Pharmacol Ther |
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Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. |
2014 |
Toxicol. Appl. Pharmacol. |
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Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. |
2014 |
Pharm Biol |
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Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. |
2014 |
Phytother Res |
pmid:23463646
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Liu J et al. |
Screening of osteoanagenesis-active compounds from Scutellaria baicalensis Georgi by hPDLC/CMC-online-HPLC/MS. |
2014 |
Fitoterapia |
pmid:24393619
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Fong SY and Zuo Z |
Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. |
2014 |
Xenobiotica |
pmid:24168065
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Wang H et al. |
Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. |
2014 |
Mol. Carcinog. |
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[Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells]. |
2014 |
Zhongguo Zhong Yao Za Zhi |
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Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. |
2014 |
Molecules |
pmid:24566319
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Yeh CH et al. |
Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. |
2014 |
Environ. Toxicol. |
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The role of wogonin in controlling SOCS3 expression in neuronal cells. |
2014 |
Biochem. Biophys. Res. Commun. |
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Zhang F and Wang G |
A review of non-nucleoside anti-hepatitis B virus agents. |
2014 |
Eur J Med Chem |
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Yao J et al. |
Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. |
2014 |
Immunology |
pmid:24766487
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Zhang Y et al. |
V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. |
2014 |
Arch. Toxicol. |
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Marsh Z et al. |
Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. |
2014 |
Phytochemistry |
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Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis. |
2014 |
Fitoterapia |
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Yan T et al. |
Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. |
2014 |
Diagn Pathol |
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Zhao K et al. |
Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. |
2014 |
PLoS ONE |
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Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. |
2014 |
Oncotarget |
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NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. |
2014 |
Cell Death Dis |
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Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. |
2014 |
Molecules |
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Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway. |
2014 |
Biochem. Pharmacol. |
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Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes. |
2014 |
Biochem. Biophys. Res. Commun. |
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Ku SK and Bae JS |
Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. |
2014 |
Fitoterapia |
pmid:25020199
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Tian J et al. |
A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. |
2014 |
Drug Deliv |
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Lin CC et al. |
Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. |
2013 Nov-Dec |
In Vivo |
pmid:24292576
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Zhong Y et al. |
Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. |
2013 |
Mol. Carcinog. |
pmid:22593043
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Xu F et al. |
The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. |
2013 |
J Pharm Sci |
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Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. |
2013 |
J Nat Med |
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Yu C et al. |
Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. |
2013 |
Pharm Biol |
pmid:23738852
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Wang Y et al. |
GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. |
2013 |
Toxicol. Lett. |
pmid:23872260
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Zhao L et al. |
Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. |
2013 |
Biochem. Cell Biol. |
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Wang F et al. |
Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. |
2013 |
Toxicology |
pmid:23246481
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Kimura Y and Sumiyoshi M |
Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. |
2013 |
Phytomedicine |
pmid:23219337
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Wang CZ et al. |
Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. |
2013 |
Int. J. Oncol. |
pmid:23337959
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Yang L et al. |
Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. |
2013 |
Apoptosis |
pmid:23371323
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Song X et al. |
Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. |
2013 |
Toxicol. Appl. Pharmacol. |
pmid:23707765
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Zhang M et al. |
Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. |
2013 |
Life Sci. |
pmid:23142241
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Chengcheng G et al. |
Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. |
2013 |
Afr Health Sci |
pmid:24250287
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Chen XM et al. |
Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. |
2013 |
PLoS ONE |
pmid:24265759
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He L et al. |
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. |
2013 |
Toxicology |
pmid:23907061
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Chirumbolo S |
Anticancer properties of the flavone wogonin. |
2013 |
Toxicology |
pmid:23994129
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Zhou YQ et al. |
[Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. |
2013 |
Sichuan Da Xue Xue Bao Yi Xue Ban |
pmid:24490490
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Kim MS et al. |
Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. |
2013 |
Cell Biol. Toxicol. |
pmid:23955116
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Attia SM et al. |
Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. |
2013 |
Food Chem. Toxicol. |
pmid:23872129
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Kim SG et al. |
Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas. |
2013 |
J Nat Med |
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Kim TW et al. |
Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. |
2013 |
Planta Med. |
pmid:23818268
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Chen CC et al. |
Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. |
2012 |
PLoS ONE |
pmid:22272328
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Xia Y et al. |
A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. |
2012 |
J Pharm Biomed Anal |
pmid:22906689
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Shao YX et al. |
The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. |
2012 |
Eur. Biophys. J. |
pmid:22228220
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Li J et al. |
Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. |
2012 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:22192416
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Huang KF et al. |
Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. |
2012 |
Int. Immunopharmacol. |
pmid:22182776
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Cheng J et al. |
Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. |
2012 |
Int J Nanomedicine |
pmid:22745547
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He F et al. |
Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. |
2012 |
Oncol. Rep. |
pmid:22665077
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Shih HC and Yang LL |
Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. |
2012 |
Pharm Biol |
pmid:22471999
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Ma X et al. |
[Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. |
2012 |
Sheng Li Xue Bao |
pmid:22513472
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Wang L et al. |
Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. |
2012 |
Int J Nanomedicine |
pmid:22359456
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Zhu Y et al. |
Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry. |
2012 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:22883103
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Lin CM et al. |
Functional role of wogonin in anti-angiogenesis. |
2012 |
Am. J. Chin. Med. |
pmid:22419433
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Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. |
2012 |
Cell. Signal. |
pmid:22846543
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Yang Y et al. |
Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. |
2012 |
PLoS ONE |
pmid:23251389
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Dong LL et al. |
An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. |
2012 |
Food Chem |
pmid:25683416
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Ci X et al. |
Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. |
2012 |
PLoS ONE |
pmid:22563373
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Chen SS et al. |
Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. |
2012 |
Discov Med |
pmid:22284780
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Li X et al. |
Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. |
2012 |
Evid Based Complement Alternat Med |
pmid:22235229
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Chow SE et al. |
Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. |
2012 |
J. Cell. Biochem. |
pmid:22689083
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Wang TC et al. |
Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest. |
2012 |
Evid Based Complement Alternat Med |
pmid:22693529
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Xia B et al. |
A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. |
2012 |
Mol. Pharm. |
pmid:23033922
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Toton E et al. |
The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. |
2012 |
Eur. J. Pharmacol. |
pmid:22381066
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Tong L et al. |
Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. |
2012 |
J Pharm Biomed Anal |
pmid:22703838
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Pham TA et al. |
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. |
2012 |
Bioorg. Med. Chem. Lett. |
pmid:22366656
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Chen H et al. |
A new strategy for quality control and qualitative analysis of Yinhuang preparations by HPLC-DAD-MS/MS. |
2012 |
Anal Bioanal Chem |
pmid:22885972
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Ha SK et al. |
6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. |
2012 |
Neuropharmacology |
pmid:22465818
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Hayasaka S et al. |
Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review. |
2012 |
Am. J. Chin. Med. |
pmid:22928823
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Chen S et al. |
Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:23063682
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Huan SK et al. |
Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. |
2012 |
Molecules |
pmid:22634839
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Li Y et al. |
Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:22560901
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Li WJ et al. |
Phenolic compounds and antioxidant activities of Liriope muscari. |
2012 |
Molecules |
pmid:22328078
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Matsunaga T et al. |
Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. |
2012 |
Front Pharmacol |
pmid:22319498
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Qi XF et al. |
Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. |
2012 |
Evid Based Complement Alternat Med |
pmid:21785648
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Ho FM et al. |
Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. |
2012 |
J Ethnopharmacol |
pmid:22543166
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Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. |
2012 |
Biotechnol. Lett. |
pmid:22639092
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He H et al. |
Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. |
2012 |
J Pharm Biomed Anal |
pmid:22260968
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Li HY et al. |
Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα. |
2012 |
J. Biomed. Biotechnol. |
pmid:22536016
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Koppula S et al. |
Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease. |
2012 |
Mediators Inflamm. |
pmid:22577256
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Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. |
2012 |
Oxid Med Cell Longev |
pmid:22701758
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Islam MN et al. |
A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. |
2012 |
Nat. Prod. Res. |
pmid:22304335
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Kim SJ et al. |
Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. |
2012 |
Mol Med Rep |
pmid:22992837
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Dandawate S et al. |
Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. |
2012 |
Cancer Immunol. Immunother. |
pmid:22057676
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Eylenstein A et al. |
Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. |
2012 |
J. Biol. Chem. |
pmid:22110130
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Cao XD et al. |
Antitumor constituents from the leaves of Carya cathayensis. |
2012 |
Nat. Prod. Res. |
pmid:22007794
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Lu QY et al. |
Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. |
2012 |
Pancreas |
pmid:22158070
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Li C et al. |
Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. |
2012 |
AAPS J |
pmid:22167378
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Ding J et al. |
Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. |
2012 |
J. Biol. Chem. |
pmid:22086925
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Zhu J et al. |
Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis. |
2012 |
PLoS ONE |
pmid:22590504
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Lo YC et al. |
Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo. |
2012 |
Evid Based Complement Alternat Med |
pmid:22474505
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Chi DS et al. |
Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. |
2012 |
Clin Mol Allergy |
pmid:22309647
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Kim JO et al. |
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. |
2012 |
Phytother Res |
pmid:22388989
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Zhang N et al. |
A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. |
2012 |
Evid Based Complement Alternat Med |
pmid:22272213
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Kang SH et al. |
Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. |
2012 |
PLoS ONE |
pmid:22493659
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