Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Carcinoma D002277 18 associated lipids
Gastritis D005756 27 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Glioma D005910 112 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Brain Ischemia D002545 89 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Translocation, Genetic D014178 20 associated lipids
Papillomavirus Infections D030361 4 associated lipids
Per page 10 20 50 | Total 24

PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
Chen CY et al. Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae. 2011 Am. J. Chin. Med. pmid:21905290
Kimura Y and Sumiyoshi M Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. 2011 Eur. J. Pharmacol. pmid:21549115
Yang DZ et al. Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. 2011 Talanta pmid:21726714
Li T et al. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. 2011 Eur J Drug Metab Pharmacokinet pmid:21713461
Lee YM et al. Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. 2011 J. Cardiovasc. Pharmacol. pmid:21436723
Messaoudene D et al. Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease. 2011 J Inflamm (Lond) pmid:22104639
Tayarani-Najaran Z et al. Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. 2011 Evid Based Complement Alternat Med pmid:20028719
Katrahalli U et al. Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods. 2010 Oct-Dec Sci Pharm pmid:21179322
Hung CW et al. Stem cell-based neuroprotective and neurorestorative strategies. 2010 Int J Mol Sci pmid:20559500
Lin CW et al. 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression. 2010 J. Cell. Physiol. pmid:20458747
Jeong HJ et al. Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. 2010 J Neuroinflammation pmid:21108840
Ni Y et al. Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches. 2010 Anal. Chim. Acta pmid:20206002
Jang S et al. Wogonin inhibits osteoclast formation induced by lipopolysaccharide. 2010 Phytother Res pmid:19998398
Meng X et al. Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. 2010 Parkinsons Dis pmid:20976092
Zhou Q et al. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. 2010 Pharm. Res. pmid:20411407
Khoo BY et al. Apoptotic effects of chrysin in human cancer cell lines. 2010 Int J Mol Sci pmid:20559509
Kunwar RM et al. Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. 2010 J Ethnobiol Ethnomed pmid:21144003
Wang CZ et al. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. 2010 Phytomedicine pmid:19836937
Ye G et al. Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry. 2010 Chem. Biodivers. pmid:21162005
Tilton R et al. A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. 2010 Chin Med pmid:20727161
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Liang X et al. Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry. 2010 J Pharm Biomed Anal pmid:19783115
Wei L et al. Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. 2010 J. Cell. Biochem. pmid:21053277
Lim JS et al. Wogonin induces differentiation and neurite outgrowth of neural precursor cells. 2010 Biochem. Biophys. Res. Commun. pmid:20888794
Lei W et al. Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. 2010 Genet. Mol. Biol. pmid:21637484
Huang ST et al. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. 2010 Phytomedicine pmid:19577445
Ijaz AZ et al. MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge. 2010 BMC Bioinformatics pmid:20406501
Cui X et al. Traditional Chinese medicine and related active compounds against hepatitis B virus infection. 2010 Biosci Trends pmid:20448340
Ozmen A et al. In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. 2010 Phytomedicine pmid:19576743
Zhao Q et al. Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. 2010 Toxicol. Lett. pmid:20570612
Xu H et al. Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. 2010 Bioresour. Technol. pmid:20708926
Ishii K et al. Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. 2010 Cancer Invest. pmid:19863351
Schrader KK Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). 2010 Toxins (Basel) pmid:22069655
Gao J et al. Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. 2010 J Pharm Biomed Anal pmid:20457505
Feng J et al. Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. 2010 J Pharm Biomed Anal pmid:20430560
You J et al. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. 2010 J Chromatogr A pmid:20138285
Kong EK et al. Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. 2010 BMB Rep pmid:20423617
Lu B et al. Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. 2009 Sep-Oct Phytochem Anal pmid:19533595
Kaneko T et al. Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage. 2009 Jul-Aug In Vivo pmid:19567393
Willimott S et al. An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells. 2009 Chem Cent J pmid:19785738
Feng Y et al. Bear bile: dilemma of traditional medicinal use and animal protection. 2009 J Ethnobiol Ethnomed pmid:19138420
Tran TD et al. Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. 2009 Bioorg. Med. Chem. Lett. pmid:19233646
Lee E et al. Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723047
Qi Q et al. Toxicological studies of wogonin in experimental animals. 2009 Phytother Res pmid:19003942
Li-Weber M New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. 2009 Cancer Treat. Rev. pmid:19004559
Rushworth SA and Micheau O Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. 2009 Br. J. Pharmacol. pmid:19664138
Kallifatidis G et al. Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. 2009 Gut pmid:18829980
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Parekh HS et al. A new dawn for the use of traditional Chinese medicine in cancer therapy. 2009 Mol. Cancer pmid:19298677
Si D et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. 2009 Drug Metab. Dispos. pmid:19074529