| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Seong RK et al. | Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways. | Acta Virol. | pmid:29521106 | |
| pmid: | ||||
| Kaneko T et al. | Inhibition of prostaglandin E2 production by flavone and its related compounds. | In Vivo | pmid:20133976 | |
| Ono K et al. | Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. | 1990 | Eur. J. Biochem. | pmid:1695572 |
| Huang HC et al. | Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell. | 1994 | Eur. J. Pharmacol. | pmid:8137874 |
| Lin SJ et al. | Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation sann-joong-kuey-jian-tang by high-performance liquid chromatography. | 1996 | J Chromatogr A | pmid:8680588 |
| Tsai TH et al. | Determination of wogonin in rat plasma by liquid chromatography and its pharmacokinetic application. | 1996 | Planta Med. | pmid:8693042 |
| Lin CC and Shieh DE | The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. | 1996 | Am. J. Chin. Med. | pmid:8739179 |
| Park HJ et al. | Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells. | 1998 | Eur. J. Cancer Prev. | pmid:9926295 |
| Nakahata N et al. | Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells. | 1998 | Am. J. Chin. Med. | pmid:9862019 |
| Zhang YY et al. | Comparative study of Scutellaria planipes and Scutellaria baicalensis. | 1998 Jan-Feb | Biomed. Chromatogr. | pmid:9470972 |
| Gao Z et al. | Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. | 1999 | Biochim. Biophys. Acta | pmid:10564778 |
| Wakabayashi I | Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages. | 1999 | Pharmacol. Toxicol. | pmid:10401731 |
| Kim HM et al. | The nitric oxide-producing activities of Scutellaria baicalensis. | 1999 | Toxicology | pmid:10463767 |
| Ueng YF et al. | Effects of baicalein and wogonin on drug-metabolizing enzymes in C57BL/6J mice. | 2000 | Life Sci. | pmid:11045600 |
| Ikemoto S et al. | Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. | 2000 | Urology | pmid:10840124 |
| Wakabayashi I and Yasui K | Wogonin inhibits inducible prostaglandin E(2) production in macrophages. | 2000 | Eur. J. Pharmacol. | pmid:11040356 |
| Huang RL et al. | Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. | 2000 | Planta Med. | pmid:11199123 |
| Ueng YF et al. | Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. | 2001 | Biochem. Pharmacol. | pmid:11755119 |
| Chen YC et al. | Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. | 2001 | Biochem. Pharmacol. | pmid:11331078 |
| Gao Z et al. | Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. | 2001 | Pharmacol. Res. | pmid:11243719 |
| Zuo F et al. | Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography. | 2001 | Biol. Pharm. Bull. | pmid:11411561 |
| Park BK et al. | Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. | 2001 | Eur. J. Pharmacol. | pmid:11502282 |
| Kim H et al. | The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production. | 2001 | Neurosci. Lett. | pmid:11489548 |
| Chang YL et al. | Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. | 2001 | Mol. Pharmacol. | pmid:11502881 |
| Van Dien M et al. | Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice. | 2001 | Microbiol. Immunol. | pmid:11791668 |
| Chi YS et al. | Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. | 2001 | Biochem. Pharmacol. | pmid:11322923 |
| Kim BR et al. | Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. | 2001 | Planta Med. | pmid:11488450 |
| Nagaki Y et al. | Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. | 2001 May-Jun | Jpn. J. Ophthalmol. | pmid:11369368 |
| Hong T et al. | Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice. | 2002 | Planta Med. | pmid:11914968 |
| Chang WH et al. | Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. | 2002 | Planta Med. | pmid:11859462 |
| Ma SC et al. | Antiviral Chinese medicinal herbs against respiratory syncytial virus. | 2002 | J Ethnopharmacol | pmid:11801383 |
| Xie LH et al. | Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography. | 2002 | Chem. Pharm. Bull. | pmid:12130846 |
| Isobe T et al. | [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. | 2002 | Yakugaku Zasshi | pmid:11968842 |
| Zuo F et al. | Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora. | 2002 | Biol. Pharm. Bull. | pmid:12033492 |
| Liu ZL et al. | Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites. | 2002 | Biol. Pharm. Bull. | pmid:11824553 |
| Lee WR et al. | Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. | 2002 | Biochem. Pharmacol. | pmid:11841797 |
| Chen X et al. | Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12113983 |
| Chen YC et al. | Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. | 2002 | Arch. Toxicol. | pmid:12107653 |
| Hui KM et al. | Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. | 2002 | Biochem. Pharmacol. | pmid:12392823 |
| Shen SC et al. | In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. | 2002 | Eur. J. Pharmacol. | pmid:12098601 |
| Du Y et al. | [Determination of wogonin in rat plasma by liquid chromatography-tandem mass spectrometry]. | 2002 | Yao Xue Xue Bao | pmid:12579842 |
| Chiu JH et al. | Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line. | 2002 | Planta Med. | pmid:12451498 |
| Lin YT et al. | Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. | 2003 | Biol. Pharm. Bull. | pmid:12736527 |
| Lee HH et al. | Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. | 2003 | Brain Res. | pmid:12965234 |
| Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
| Nakamura N et al. | Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line. | 2003 | Exp. Eye Res. | pmid:12873450 |
| Zuo F et al. | Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats. | 2003 | Biol. Pharm. Bull. | pmid:12843610 |
| Huang WH et al. | Novel synthesis of flavonoids of Scutellaria baicalensis Georgi. | 2003 | Chem. Pharm. Bull. | pmid:12612426 |
| Lim BO | Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes. | 2003 | J Ethnopharmacol | pmid:12499072 |
| Lee H et al. | Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. | 2003 | FASEB J. | pmid:12897065 |
| Li DR et al. | [Effects of wogonin on inducing apoptosis of human ovarian cancer A2780 cells and telomerase activity]. | 2003 | Ai Zheng | pmid:12917023 |
| Chi YS et al. | Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. | 2003 | Biochem. Pharmacol. | pmid:14505806 |
| Wang Z et al. | Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells. | 2003 | BJU Int. | pmid:14616461 |
| Pal M et al. | Antifungal activity of wogonin. | 2003 | Phytother Res | pmid:14669259 |
| Lim BO et al. | Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12834292 |
| Nagaki Y et al. | Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits. | 2003 May-Jun | Jpn. J. Ophthalmol. | pmid:12782159 |
| Dao TT et al. | Synthesis and biological activities of 8-arylflavones. | 2004 | Arch. Pharm. Res. | pmid:15089030 |
| Sonoda M et al. | Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. | 2004 | J Ethnopharmacol | pmid:15036470 |
| Woźniak D et al. | Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis georgi. | 2004 | Nahrung | pmid:15053344 |
| Murch SJ et al. | A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds. | 2004 | Plant Cell Rep. | pmid:15449017 |
| Scuro LS et al. | Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. | 2004 | BMC Biochem. | pmid:15102332 |
| Son D et al. | Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. | 2004 | Eur. J. Pharmacol. | pmid:15189769 |
| Lim H et al. | Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin. | 2004 | Arch. Pharm. Res. | pmid:15180311 |
| Park S et al. | Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. | 2004 | Dig. Dis. Sci. | pmid:15139485 |
| Cho J and Lee HK | Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. | 2004 | Eur. J. Pharmacol. | pmid:14757129 |
| Li HB et al. | Separation methods used for Scutellaria baicalensis active components. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15556504 |
| Ong ES et al. | Proteomic analysis of mouse liver for the evaluation of effects of Scutellariae radix by liquid chromatography with tandem mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15468106 |
| Chen TJ et al. | Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase. | 2004 | Toxicol. Lett. | pmid:14700523 |
| Lim BO | Efficacy of wogonin in the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618621 |
| Chaudhuri PK et al. | Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. | 2004 | Phytother Res | pmid:15022161 |
| Tian J et al. | Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15043845 |
| Cho J and Lee HK | Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. | 2004 | Biol. Pharm. Bull. | pmid:15467195 |
| Piao HZ et al. | Neuroprotective effect of wogonin: potential roles of inflammatory cytokines. | 2004 | Arch. Pharm. Res. | pmid:15473663 |
| Tian J et al. | Interaction of wogonin with bovine serum albumin. | 2005 | Bioorg. Med. Chem. | pmid:15911327 |
| Chuang HN et al. | Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line. | 2005 | Planta Med. | pmid:15931583 |
| Tai MC et al. | Therapeutic potential of wogonin: a naturally occurring flavonoid. | 2005 | CNS Drug Rev | pmid:16007236 |
| Li C et al. | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. | 2005 | Biomed. Chromatogr. | pmid:15627280 |
| Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
| Aung H et al. | Scutellaria baicalensis decreases ritonavir-induced nausea. | 2005 | AIDS Res Ther | pmid:16368007 |
| Dao TT et al. | Synthesis and iNOS inhibitory activities of thioflavones. | 2005 | Arch. Pharm. Res. | pmid:16042072 |
| Hardeland R and Pandi-Perumal SR | Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug. | 2005 | Nutr Metab (Lond) | pmid:16153306 |
| Bonham M et al. | Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. | 2005 | Clin. Cancer Res. | pmid:15897592 |
| Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
| Park EJ et al. | Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells. | 2005 | Planta Med. | pmid:16206047 |
| Jang J et al. | Structure and antiinflammatory activity relationships of wogonin derivatives. | 2005 | Arch. Pharm. Res. | pmid:16178410 |
| Han CK et al. | Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism. | 2005 | Biol. Pharm. Bull. | pmid:16079475 |
| Ma Z et al. | Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. | 2005 | Blood | pmid:15626742 |
| Goh D et al. | Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. | 2005 | J. Agric. Food Chem. | pmid:16218664 |
| Li HB and Chen F | Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:15941045 |
| Ohtake N et al. | The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. | 2005 | Eur. J. Pharmacol. | pmid:15659321 |
| Chun W et al. | Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity. | 2005 | Arch. Pharm. Res. | pmid:15789754 |
| Chi YS and Kim HP | Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589400 |
| Du CF et al. | [Studies on chemical constituents in bark of dictamnus dasycarpus]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16400943 |
| Liu Y et al. | Binding of wogonin to human gammaglobulin. | 2005 | Int. J. Biol. Macromol. | pmid:16242767 |
| Yu CS et al. | Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells. | 2005 Jan-Feb | Anticancer Res. | pmid:15816529 |
| Lin CM et al. | Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1. | 2006 | Int. Immunopharmacol. | pmid:16979123 |
| Wang W et al. | Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. | 2006 | Anticancer Drugs | pmid:16926629 |
| Adams LS et al. | Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. | 2006 | Evid Based Complement Alternat Med | pmid:16550232 |
| Huang WH et al. | Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. | 2006 | Biosci. Biotechnol. Biochem. | pmid:17031041 |