Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

Cross Reference

Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Carcinoma D002277 18 associated lipids
Per page 10 20 50 | Total 24

PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
pmid:
Li C et al. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. 2012 AAPS J pmid:22167378
Shi G et al. Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics. 2017 Acta Biochim. Biophys. Sin. (Shanghai) pmid:28338770
Salmani JMM et al. Development of a new HPLC method for wogonin in rat plasma: Compatibility of standard and test samples. 2017 Acta Pharm pmid:28858841
Dai JY et al. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. 2008 Acta Pharmacol. Sin. pmid:18718184
Liu YM et al. Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. 2011 Acta Pharmacol. Sin. pmid:21986573
Wohlfarth C and Efferth T Natural products as promising drug candidates for the treatment of hepatitis B and C. 2009 Acta Pharmacol. Sin. pmid:19060918
Zhang YM et al. Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. 2015 Acta Pharmacol. Sin. pmid:26073326
Kim EJ et al. Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel. 2011 Acta Physiol (Oxf) pmid:21306568
Seong RK et al. Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways. Acta Virol. pmid:29521106
Chengcheng G et al. Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. 2013 Afr Health Sci pmid:24250287
Li DR et al. [Effects of wogonin on inducing apoptosis of human ovarian cancer A2780 cells and telomerase activity]. 2003 Ai Zheng pmid:12917023
Aung H et al. Scutellaria baicalensis decreases ritonavir-induced nausea. 2005 AIDS Res Ther pmid:16368007
Ryu NH et al. Wogonin inhibits transforming growth factor β1-induced extracellular matrix production via the p38/activator protein 1 signaling pathway in nasal polyp-derived fibroblasts. 2016 Am J Rhinol Allergy pmid:27456588
Chang WT et al. Cardioprotective effects of grape seed proanthocyanidins, baicalin and wogonin: comparison between acute and chronic treatments. 2006 Am. J. Chin. Med. pmid:16700106
Lin CM et al. Functional role of wogonin in anti-angiogenesis. 2012 Am. J. Chin. Med. pmid:22419433
Hayasaka S et al. Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review. 2012 Am. J. Chin. Med. pmid:22928823
Chen CY et al. Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae. 2011 Am. J. Chin. Med. pmid:21905290
Lin CC and Shieh DE The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. 1996 Am. J. Chin. Med. pmid:8739179
Nakahata N et al. Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells. 1998 Am. J. Chin. Med. pmid:9862019
Lucas CD et al. Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation. 2015 Am. J. Respir. Crit. Care Med. pmid:25629436
Persson C Drug-induced death of eosinophils. Promises and pitfalls. 2015 Am. J. Respir. Crit. Care Med. pmid:25767918
Chen H et al. A new strategy for quality control and qualitative analysis of Yinhuang preparations by HPLC-DAD-MS/MS. 2012 Anal Bioanal Chem pmid:22885972
Xu L et al. Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. 2009 Anal. Chim. Acta pmid:19110127
Ni Y et al. Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches. 2010 Anal. Chim. Acta pmid:20206002
Lee E et al. Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723047
Enomoto R et al. Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. 2007 Ann. N. Y. Acad. Sci. pmid:17404053
Lee E et al. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. 2007 Ann. N. Y. Acad. Sci. pmid:17404065
Wang W et al. Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. 2006 Anticancer Drugs pmid:16926629
Yu CS et al. Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells. 2005 Jan-Feb Anticancer Res. pmid:15816529
Guo Q et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo. 2007 Antiviral Res. pmid:17280723
Yang L et al. Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. 2013 Apoptosis pmid:23371323
Kim EH et al. Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer. 2016 Apoptosis pmid:27544755
Ku SK et al. Inhibitory effect of baicalin, baicalein and wogonin on secretory group IIA phospholipase A2. 2015 Arch. Pharm. Res. pmid:25564337
Dao TT et al. Synthesis and biological activities of 8-arylflavones. 2004 Arch. Pharm. Res. pmid:15089030
Kim YH et al. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. 2007 Arch. Pharm. Res. pmid:17366750
Dao TT et al. Synthesis and iNOS inhibitory activities of thioflavones. 2005 Arch. Pharm. Res. pmid:16042072
Jang J et al. Structure and antiinflammatory activity relationships of wogonin derivatives. 2005 Arch. Pharm. Res. pmid:16178410
Lim H et al. Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin. 2004 Arch. Pharm. Res. pmid:15180311
Gurung SK et al. Inhibition of prostaglandin E2 production by synthetic wogonin analogs. 2009 Arch. Pharm. Res. pmid:20091262
Oche B et al. Cryptotanshinone and wogonin up-regulate eNOS in vascular endothelial cells via ERα and down-regulate iNOS in LPS stimulated vascular smooth muscle cells via ERβ. 2016 Arch. Pharm. Res. pmid:26481132
Chun W et al. Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity. 2005 Arch. Pharm. Res. pmid:15789754
Piao HZ et al. Neuroprotective effect of wogonin: potential roles of inflammatory cytokines. 2004 Arch. Pharm. Res. pmid:15473663
Zhang Y et al. V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. 2014 Arch. Toxicol. pmid:23835921
Chen YC et al. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. 2002 Arch. Toxicol. pmid:12107653
Jung SM et al. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. 2007 Arthritis Res. Ther. pmid:17612394
Kauss T et al. Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. 2008 Arthritis Res. Ther. pmid:18252009
Coleta M et al. Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity. 2008 Behav. Brain Res. pmid:18249450
Zhou XQ et al. [Flavonoids from Scutellaria baicalensis and their bioactivities]. 2009 Beijing Da Xue Xue Bao pmid:19829679
Lee SO et al. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. 2006 Biochem. Biophys. Res. Commun. pmid:17052690