Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Carcinoma D002277 18 associated lipids
Per page 10 20 50 | Total 24

PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
pmid:
Wakabayashi I Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages. 1999 Pharmacol. Toxicol. pmid:10401731
Kim HM et al. The nitric oxide-producing activities of Scutellaria baicalensis. 1999 Toxicology pmid:10463767
Gao Z et al. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. 1999 Biochim. Biophys. Acta pmid:10564778
Ikemoto S et al. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. 2000 Urology pmid:10840124
Wakabayashi I and Yasui K Wogonin inhibits inducible prostaglandin E(2) production in macrophages. 2000 Eur. J. Pharmacol. pmid:11040356
Ueng YF et al. Effects of baicalein and wogonin on drug-metabolizing enzymes in C57BL/6J mice. 2000 Life Sci. pmid:11045600
Huang RL et al. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. 2000 Planta Med. pmid:11199123
Gao Z et al. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. 2001 Pharmacol. Res. pmid:11243719
Chi YS et al. Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. 2001 Biochem. Pharmacol. pmid:11322923
Chen YC et al. Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. 2001 Biochem. Pharmacol. pmid:11331078
Nagaki Y et al. Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. 2001 May-Jun Jpn. J. Ophthalmol. pmid:11369368
Zuo F et al. Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography. 2001 Biol. Pharm. Bull. pmid:11411561
Kim BR et al. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. 2001 Planta Med. pmid:11488450
Kim H et al. The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production. 2001 Neurosci. Lett. pmid:11489548
Park BK et al. Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. 2001 Eur. J. Pharmacol. pmid:11502282
Chang YL et al. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. 2001 Mol. Pharmacol. pmid:11502881
Ueng YF et al. Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. 2001 Biochem. Pharmacol. pmid:11755119
Van Dien M et al. Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice. 2001 Microbiol. Immunol. pmid:11791668
Ma SC et al. Antiviral Chinese medicinal herbs against respiratory syncytial virus. 2002 J Ethnopharmacol pmid:11801383
Liu ZL et al. Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites. 2002 Biol. Pharm. Bull. pmid:11824553
Lee WR et al. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. 2002 Biochem. Pharmacol. pmid:11841797
Chang WH et al. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. 2002 Planta Med. pmid:11859462
Hong T et al. Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice. 2002 Planta Med. pmid:11914968
Isobe T et al. [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. 2002 Yakugaku Zasshi pmid:11968842
Zuo F et al. Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora. 2002 Biol. Pharm. Bull. pmid:12033492
Shen SC et al. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. 2002 Eur. J. Pharmacol. pmid:12098601
Chen YC et al. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. 2002 Arch. Toxicol. pmid:12107653
Chen X et al. Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry. 2002 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12113983
Xie LH et al. Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography. 2002 Chem. Pharm. Bull. pmid:12130846
Hui KM et al. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. 2002 Biochem. Pharmacol. pmid:12392823
Chiu JH et al. Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line. 2002 Planta Med. pmid:12451498
Lim BO Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes. 2003 J Ethnopharmacol pmid:12499072
Lai MY et al. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. 2003 Biol. Pharm. Bull. pmid:12520178
Du Y et al. [Determination of wogonin in rat plasma by liquid chromatography-tandem mass spectrometry]. 2002 Yao Xue Xue Bao pmid:12579842
Huang WH et al. Novel synthesis of flavonoids of Scutellaria baicalensis Georgi. 2003 Chem. Pharm. Bull. pmid:12612426
Lin YT et al. Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. 2003 Biol. Pharm. Bull. pmid:12736527
Nagaki Y et al. Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits. 2003 May-Jun Jpn. J. Ophthalmol. pmid:12782159
Lim BO et al. Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats. 2003 Biosci. Biotechnol. Biochem. pmid:12834292
Zuo F et al. Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats. 2003 Biol. Pharm. Bull. pmid:12843610
Nakamura N et al. Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line. 2003 Exp. Eye Res. pmid:12873450
Lee H et al. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. 2003 FASEB J. pmid:12897065
Li DR et al. [Effects of wogonin on inducing apoptosis of human ovarian cancer A2780 cells and telomerase activity]. 2003 Ai Zheng pmid:12917023
Lee HH et al. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. 2003 Brain Res. pmid:12965234
Chi YS et al. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. 2003 Biochem. Pharmacol. pmid:14505806
Wang Z et al. Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells. 2003 BJU Int. pmid:14616461
Pal M et al. Antifungal activity of wogonin. 2003 Phytother Res pmid:14669259
Chen TJ et al. Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase. 2004 Toxicol. Lett. pmid:14700523
Cho J and Lee HK Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. 2004 Eur. J. Pharmacol. pmid:14757129
Chaudhuri PK et al. Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. 2004 Phytother Res pmid:15022161