Wilczańska-Barska A et al. |
Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. |
2012 |
Biotechnol. Lett. |
pmid:22639092
|
Wang Z et al. |
Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells. |
2003 |
BJU Int. |
pmid:14616461
|
Fas SC et al. |
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. |
2006 |
Blood |
pmid:16931628
|
Ma Z et al. |
Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. |
2005 |
Blood |
pmid:15626742
|
Baumann S et al. |
Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. |
2008 |
Blood |
pmid:18070986
|
Ku SK and Bae JS |
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo. |
2015 |
BMB Rep |
pmid:25739393
|
Kong EK et al. |
Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. |
2010 |
BMB Rep |
pmid:20423617
|
Scuro LS et al. |
Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. |
2004 |
BMC Biochem. |
pmid:15102332
|
Ijaz AZ et al. |
MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge. |
2010 |
BMC Bioinformatics |
pmid:20406501
|
Tang H et al. |
The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. |
2011 |
BMC Biol. |
pmid:21418589
|
Wu X et al. |
Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway. |
2017 |
BMC Cancer |
pmid:28222771
|
Wu B et al. |
Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. |
2011 |
BMC Cancer |
pmid:22204275
|
Huynh DL et al. |
Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression. |
2017 |
BMC Complement Altern Med |
pmid:28606135
|
Ahn SH et al. |
Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. |
2011 |
BMC Neurosci |
pmid:21810275
|
Rushworth SA and Micheau O |
Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. |
2009 |
Br. J. Pharmacol. |
pmid:19664138
|
Lee DH et al. |
Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. |
2009 |
Br. J. Pharmacol. |
pmid:19438509
|
Lee HH et al. |
Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. |
2003 |
Brain Res. |
pmid:12965234
|
Chow SE et al. |
Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:21207227
|
Enomoto R et al. |
Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:20658136
|
Dandawate S et al. |
Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. |
2012 |
Cancer Immunol. Immunother. |
pmid:22057676
|
Ishii K et al. |
Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. |
2010 |
Cancer Invest. |
pmid:19863351
|
Himeji M et al. |
Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. |
2007 |
Cancer Lett. |
pmid:16497434
|
Yang L et al. |
Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. |
2011 |
Cancer Sci. |
pmid:21244577
|
Zhang K et al. |
Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. |
2008 |
Cancer Sci. |
pmid:18377421
|
Li-Weber M |
New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. |
2009 |
Cancer Treat. Rev. |
pmid:19004559
|
Kim MS et al. |
Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. |
2013 |
Cell Biol. Toxicol. |
pmid:23955116
|
Chen S et al. |
Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. |
2011 |
Cell Biol. Toxicol. |
pmid:20872277
|
Yao J et al. |
NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. |
2014 |
Cell Death Dis |
pmid:24901054
|
Polier G et al. |
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. |
2011 |
Cell Death Dis |
pmid:21776020
|
Chen S et al. |
Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25504431
|
Xu S et al. |
Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25381475
|
Sukkar B et al. |
Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin. |
2018 |
Cell. Physiol. Biochem. |
pmid:30453283
|
Al-Maghout T et al. |
P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes. |
2017 |
Cell. Physiol. Biochem. |
pmid:28813704
|
Lee DH et al. |
Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. |
2012 |
Cell. Signal. |
pmid:22846543
|
Willimott S et al. |
An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells. |
2009 |
Chem Cent J |
pmid:19785738
|
Ye G et al. |
Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry. |
2010 |
Chem. Biodivers. |
pmid:21162005
|
Su S et al. |
Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis. |
2008 |
Chem. Biodivers. |
pmid:18651621
|
Tan CX et al. |
Activities of wogonin analogs and other flavones against Flavobacterium columnare. |
2015 |
Chem. Biodivers. |
pmid:25676507
|
Khan NM et al. |
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes. |
2017 |
Chem. Biol. Interact. |
pmid:28688942
|
Xie LH et al. |
Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography. |
2002 |
Chem. Pharm. Bull. |
pmid:12130846
|
Huang WH et al. |
Novel synthesis of flavonoids of Scutellaria baicalensis Georgi. |
2003 |
Chem. Pharm. Bull. |
pmid:12612426
|
Li YQ et al. |
Two new alkaloids from Capparis himalayensis. |
2008 |
Chem. Pharm. Bull. |
pmid:18239306
|
Liu RX et al. |
Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. |
2017 |
Chin J Nat Med |
pmid:28284428
|
Huynh DL et al. |
Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. |
2017 |
Chin J Nat Med |
pmid:28259249
|
Tan W et al. |
Anti-cancer natural products isolated from chinese medicinal herbs. |
2011 |
Chin Med |
pmid:21777476
|
Tilton R et al. |
A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. |
2010 |
Chin Med |
pmid:20727161
|
Su SY and Hsieh CL |
Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. |
2011 |
Chin Med |
pmid:21740583
|
Xu PP et al. |
Wogonin Inhibits Growth of Mantle Cell Lymphoma Cells through Nuclear Factor-κB Signaling Pathway. |
2018 |
Chin. Med. J. |
pmid:29451160
|
Peng MX et al. |
Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin. |
2016 |
Chin. Med. J. |
pmid:27958228
|
Hsieh CJ et al. |
Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. |
2007 |
Clin Mol Allergy |
pmid:18039391
|
Chi DS et al. |
Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. |
2012 |
Clin Mol Allergy |
pmid:22309647
|
Bak EJ et al. |
Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. |
2014 |
Clin Nutr |
pmid:23623334
|
Bonham M et al. |
Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. |
2005 |
Clin. Cancer Res. |
pmid:15897592
|
Samarghandian S et al. |
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
pmid:21808878
|
Tai MC et al. |
Therapeutic potential of wogonin: a naturally occurring flavonoid. |
2005 |
CNS Drug Rev |
pmid:16007236
|
Gasiorowski K et al. |
Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? |
2011 |
CNS Neurol Disord Drug Targets |
pmid:21222632
|
Yan T et al. |
Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. |
2014 |
Diagn Pathol |
pmid:25432585
|
Park S et al. |
Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. |
2004 |
Dig. Dis. Sci. |
pmid:15139485
|
Chen SS et al. |
Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. |
2012 |
Discov Med |
pmid:23200064
|
Chen SS et al. |
Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. |
2012 |
Discov Med |
pmid:22284780
|
Tian J et al. |
A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. |
2014 |
Drug Deliv |
pmid:24215357
|
Si D et al. |
Mechanism of CYP2C9 inhibition by flavones and flavonols. |
2009 |
Drug Metab. Dispos. |
pmid:19074529
|
Yang T et al. |
Wogonin enhances intracellular adiponectin levels and suppresses adiponectin secretion in 3T3-L1 adipocytes. |
2017 |
Endocr. J. |
pmid:27667474
|
Yeh CH et al. |
Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. |
2014 |
Environ. Toxicol. |
pmid:23362215
|
Wei CY et al. |
Protective effect of wogonin on endotoxin-induced acute lung injury via reduction of p38 MAPK and JNK phosphorylation. |
2017 |
Environ. Toxicol. |
pmid:26892447
|
Huang FM et al. |
BisGMA-induced cytotoxicity and genotoxicity in macrophages are attenuated by wogonin via reduction of intrinsic caspase pathway activation. |
2016 |
Environ. Toxicol. |
pmid:26756871
|
Sun HL et al. |
Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α. |
2016 |
Environ. Toxicol. |
pmid:26213241
|
Boozari M et al. |
Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. |
2015 |
Environ. Toxicol. Pharmacol. |
pmid:25546119
|
Li T et al. |
Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. |
2011 |
Eur J Drug Metab Pharmacokinet |
pmid:21713461
|
Zhang Y et al. |
The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma. |
2018 |
Eur J Drug Metab Pharmacokinet |
pmid:29134502
|
Park H et al. |
Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. |
2005 |
Eur J Med Chem |
pmid:15963606
|
Zhang F and Wang G |
A review of non-nucleoside anti-hepatitis B virus agents. |
2014 |
Eur J Med Chem |
pmid:24549242
|
Wang J et al. |
Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro. |
2017 |
Eur J Med Chem |
pmid:28987604
|
Sabra SA et al. |
Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer. |
2018 |
Eur J Pharm Biopharm |
pmid:29689288
|
Shao YX et al. |
The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. |
2012 |
Eur. Biophys. J. |
pmid:22228220
|
Ono K et al. |
Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. |
1990 |
Eur. J. Biochem. |
pmid:1695572
|
Park HJ et al. |
Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells. |
1998 |
Eur. J. Cancer Prev. |
pmid:9926295
|
Zhang HW et al. |
Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation. |
2008 |
Eur. J. Pharmacol. |
pmid:18577379
|
Chang WT et al. |
Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. |
2007 |
Eur. J. Pharmacol. |
pmid:17475241
|
Park BK et al. |
Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. |
2001 |
Eur. J. Pharmacol. |
pmid:11502282
|
Toton E et al. |
The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. |
2012 |
Eur. J. Pharmacol. |
pmid:22381066
|
Shen SC et al. |
In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. |
2002 |
Eur. J. Pharmacol. |
pmid:12098601
|
Wakabayashi I and Yasui K |
Wogonin inhibits inducible prostaglandin E(2) production in macrophages. |
2000 |
Eur. J. Pharmacol. |
pmid:11040356
|
Son D et al. |
Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. |
2004 |
Eur. J. Pharmacol. |
pmid:15189769
|
Kimura Y and Sumiyoshi M |
Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. |
2011 |
Eur. J. Pharmacol. |
pmid:21549115
|
Cho J and Lee HK |
Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. |
2004 |
Eur. J. Pharmacol. |
pmid:14757129
|
Zhao Y et al. |
Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. |
2006 |
Eur. J. Pharmacol. |
pmid:16574098
|
Huang HC et al. |
Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell. |
1994 |
Eur. J. Pharmacol. |
pmid:8137874
|
Ohtake N et al. |
The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. |
2005 |
Eur. J. Pharmacol. |
pmid:15659321
|
Zhao K et al. |
Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling. |
2014 |
Eur. J. Pharmacol. |
pmid:24858369
|
Park HG et al. |
Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. |
2007 |
Eur. J. Pharmacol. |
pmid:17692312
|
Chen CM et al. |
Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats. |
2011 |
Evid Based Complement Alternat Med |
pmid:19584080
|
Shih YT et al. |
San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells. |
2011 |
Evid Based Complement Alternat Med |
pmid:19339484
|
Wang TC et al. |
Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest. |
2012 |
Evid Based Complement Alternat Med |
pmid:22693529
|
Qi XF et al. |
Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. |
2012 |
Evid Based Complement Alternat Med |
pmid:21785648
|
Chen FP et al. |
Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002. |
2011 |
Evid Based Complement Alternat Med |
pmid:19339485
|
Calvo TR et al. |
Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts. |
2011 |
Evid Based Complement Alternat Med |
pmid:19696193
|
Im AR et al. |
Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. |
2012 |
Evid Based Complement Alternat Med |
pmid:22969827
|
Pan SY et al. |
New perspectives on chinese herbal medicine (zhong-yao) research and development. |
2011 |
Evid Based Complement Alternat Med |
pmid:21785622
|
Lo YC et al. |
Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo. |
2012 |
Evid Based Complement Alternat Med |
pmid:22474505
|