Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Carcinoma D002277 18 associated lipids
Per page 10 20 50 | Total 24

PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
Pan MH et al. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. 2006 Biochem. Pharmacol. pmid:16949556
Zhang H et al. Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive. 2006 J Chromatogr A pmid:16952364
Ono K et al. Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. 1990 Eur. J. Biochem. pmid:1695572
Lin CM et al. Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1. 2006 Int. Immunopharmacol. pmid:16979123
Yu K et al. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis. 2007 J Pharm Biomed Anal pmid:16989969
Lin CM et al. Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2. 2006 Planta Med. pmid:17024605
Huang WH et al. Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. 2006 Biosci. Biotechnol. Biochem. pmid:17031041
Lee SO et al. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. 2006 Biochem. Biophys. Res. Commun. pmid:17052690
Hu Y et al. Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. 2006 Biochem. Biophys. Res. Commun. pmid:17069758
Wang HW et al. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. 2007 Int. J. Cancer pmid:17266043
Guo Q et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo. 2007 Antiviral Res. pmid:17280723
Yu JQ et al. Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells. 2007 Hepatol. Res. pmid:17300700
Lee BS et al. Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Suppressive effect of wogonin on mite antigen-induced TARC expression. 2007 J. Dermatol. Sci. pmid:17317108
Kim YH et al. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. 2007 Arch. Pharm. Res. pmid:17366750
Enomoto R et al. Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. 2007 Ann. N. Y. Acad. Sci. pmid:17404053
Lee E et al. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. 2007 Ann. N. Y. Acad. Sci. pmid:17404065
Chang WT et al. Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. 2007 Eur. J. Pharmacol. pmid:17475241
Huang GC et al. Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. 2007 Int. Immunopharmacol. pmid:17570322
Jung SM et al. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. 2007 Arthritis Res. Ther. pmid:17612394
Heo HJ et al. Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells. 2007 Phytother Res pmid:17622975
Yu J et al. Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. 2007 Phytother Res pmid:17674423
Enomoto R et al. Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. 2007 J. Pharmacol. Sci. pmid:17690528
Park HG et al. Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. 2007 Eur. J. Pharmacol. pmid:17692312
Lim H and Kim HP Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. 2007 Planta Med. pmid:17886198
Chow JM et al. Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells. 2008 J. Cell. Biochem. pmid:17955493
Chung H et al. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. 2008 Int. J. Cancer pmid:17957784
Park SS et al. Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. 2008 J. Cell. Biochem. pmid:17973296
Seo DC et al. Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells. 2007 Mol. Cancer pmid:18034892
Hsieh CJ et al. Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. 2007 Clin Mol Allergy pmid:18039391
Baumann S et al. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. 2008 Blood pmid:18070986
Chen S et al. Down-regulation of androgen-receptor and PSA by phytochemicals. 2008 Int. J. Oncol. pmid:18202763
Li YQ et al. Two new alkaloids from Capparis himalayensis. 2008 Chem. Pharm. Bull. pmid:18239306
Coleta M et al. Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity. 2008 Behav. Brain Res. pmid:18249450
Kauss T et al. Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. 2008 Arthritis Res. Ther. pmid:18252009
Hämäläinen M et al. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. 2007 Mediators Inflamm. pmid:18274639
Lee CY et al. Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters. 2008 Liver Int. pmid:18346132
Zhang K et al. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. 2008 Cancer Sci. pmid:18377421
Lee DH et al. Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. 2008 Biochem. Pharmacol. pmid:18377871
Lu N et al. Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. 2008 Life Sci. pmid:18378261
Makino T et al. Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products. 2008 J Nat Med pmid:18404307
Ohta Y et al. Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue. 2007 J Clin Biochem Nutr pmid:18437211
Gao J et al. Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. 2008 J Pharm Pharm Sci pmid:18445366
Kasai A et al. Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation. 2008 Biol. Pharm. Bull. pmid:18451504
Cole IB et al. Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry. 2008 Planta Med. pmid:18484546
Chen LG et al. Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. 2008 Mol Nutr Food Res pmid:18496814
Lin Z et al. Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds. 2008 Nov-Dec Luminescence pmid:18506909
Zhang HW et al. Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation. 2008 Eur. J. Pharmacol. pmid:18577379
Anand P et al. Cancer is a preventable disease that requires major lifestyle changes. 2008 Pharm. Res. pmid:18626751
Su S et al. Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis. 2008 Chem. Biodivers. pmid:18651621
Dai JY et al. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. 2008 Acta Pharmacol. Sin. pmid:18718184
Piao HZ et al. Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity. 2008 Int. Immunopharmacol. pmid:18725324
BÅ‚ach-Olszewska Z et al. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. 2008 J. Interferon Cytokine Res. pmid:18771341
Kallifatidis G et al. Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. 2009 Gut pmid:18829980
Qi Q et al. Toxicological studies of wogonin in experimental animals. 2009 Phytother Res pmid:19003942
Li-Weber M New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. 2009 Cancer Treat. Rev. pmid:19004559
Parajuli P et al. In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. 2009 Planta Med. pmid:19031366
Wohlfarth C and Efferth T Natural products as promising drug candidates for the treatment of hepatitis B and C. 2009 Acta Pharmacol. Sin. pmid:19060918
Si D et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. 2009 Drug Metab. Dispos. pmid:19074529
Xu L et al. Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. 2009 Anal. Chim. Acta pmid:19110127
Feng Y et al. Bear bile: dilemma of traditional medicinal use and animal protection. 2009 J Ethnobiol Ethnomed pmid:19138420
Tran TD et al. Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. 2009 Bioorg. Med. Chem. Lett. pmid:19233646
Yin L et al. Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control. 2009 J Pharm Biomed Anal pmid:19264437
Parekh HS et al. A new dawn for the use of traditional Chinese medicine in cancer therapy. 2009 Mol. Cancer pmid:19298677
Shih YT et al. San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells. 2011 Evid Based Complement Alternat Med pmid:19339484
Chen FP et al. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002. 2011 Evid Based Complement Alternat Med pmid:19339485
Peng J et al. Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. 2009 J Ethnopharmacol pmid:19397969
Lee DH et al. Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. 2009 Br. J. Pharmacol. pmid:19438509
Li C et al. Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix Scutellariae. 2009 J Pharm Biomed Anal pmid:19481403
Lu B et al. Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. 2009 Sep-Oct Phytochem Anal pmid:19533595
Li J et al. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. 2009 J. Nat. Prod. pmid:19555121
Kaneko T et al. Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage. 2009 Jul-Aug In Vivo pmid:19567393
Ozmen A et al. In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. 2010 Phytomedicine pmid:19576743
Huang ST et al. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. 2010 Phytomedicine pmid:19577445
Cao H et al. Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. 2009 J. Hazard. Mater. pmid:19577841
Chen CM et al. Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats. 2011 Evid Based Complement Alternat Med pmid:19584080
Ding XF et al. [Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy]. 2009 Guang Pu Xue Yu Guang Pu Fen Xi pmid:19650472
Rushworth SA and Micheau O Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. 2009 Br. J. Pharmacol. pmid:19664138
Calvo TR et al. Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts. 2011 Evid Based Complement Alternat Med pmid:19696193
Lee E et al. Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723047
Shia CS et al. Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity. 2011 Evid Based Complement Alternat Med pmid:19737807
Liang X et al. Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry. 2010 J Pharm Biomed Anal pmid:19783115
Willimott S et al. An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells. 2009 Chem Cent J pmid:19785738
Zhou XQ et al. [Flavonoids from Scutellaria baicalensis and their bioactivities]. 2009 Beijing Da Xue Xue Bao pmid:19829679
Wang CZ et al. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. 2010 Phytomedicine pmid:19836937
Ishii K et al. Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. 2010 Cancer Invest. pmid:19863351
Yang L et al. Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. 2009 Biochem. Cell Biol. pmid:19935879
Jang S et al. Wogonin inhibits osteoclast formation induced by lipopolysaccharide. 2010 Phytother Res pmid:19998398
Chen B et al. Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells. 2009 Int J Nanomedicine pmid:20011242
Tayarani-Najaran Z et al. Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. 2011 Evid Based Complement Alternat Med pmid:20028719
Kim HS et al. Cloning and expression of beta-glucuronidase from Lactobacillus brevis in E. coli and application in the bioconversion of baicalin and wogonoside. 2009 J. Microbiol. Biotechnol. pmid:20075633
Gurung SK et al. Inhibition of prostaglandin E2 production by synthetic wogonin analogs. 2009 Arch. Pharm. Res. pmid:20091262
Kaneko T et al. Inhibition of prostaglandin E2 production by flavone and its related compounds. In Vivo pmid:20133976
You J et al. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. 2010 J Chromatogr A pmid:20138285
Li Y et al. Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers. 2010 J Pharm Biomed Anal pmid:20138726
Ni Y et al. Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches. 2010 Anal. Chim. Acta pmid:20206002
Ijaz AZ et al. MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge. 2010 BMC Bioinformatics pmid:20406501
Zhou Q et al. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. 2010 Pharm. Res. pmid:20411407
Kong EK et al. Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. 2010 BMB Rep pmid:20423617
Feng J et al. Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. 2010 J Pharm Biomed Anal pmid:20430560
Cui X et al. Traditional Chinese medicine and related active compounds against hepatitis B virus infection. 2010 Biosci Trends pmid:20448340