Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Carcinoma D002277 18 associated lipids
Per page 10 20 50 | Total 24

PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

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Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
Li Y and Martin RC Herbal medicine and hepatocellular carcinoma: applications and challenges. 2011 Evid Based Complement Alternat Med pmid:21799681
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Ku SK and Bae JS Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. 2014 Fitoterapia pmid:25020199
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Tu B et al. Structure-activity relationship study between baicalein and wogonin by spectrometry, molecular docking and microcalorimetry. 2016 Food Chem pmid:27132840
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Khan NM et al. Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes. 2017 Free Radic. Biol. Med. pmid:28237856
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Lin CC et al. Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. 2013 Nov-Dec In Vivo pmid:24292576
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Tang NY et al. Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats. 2006 Jul-Aug In Vivo pmid:16900784
Kaneko T et al. Inhibition of prostaglandin E2 production by flavone and its related compounds. In Vivo pmid:20133976
Wang W et al. Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro. 2015 Inflamm. Res. pmid:25917044
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Tsai CF et al. Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. 2012 Int J Mol Sci pmid:22949836
Zhang H et al. A Novel Prostate-Specific Membrane-Antigen (PSMA) Targeted Micelle-Encapsulating Wogonin Inhibits Prostate Cancer Cell Proliferation via Inducing Intrinsic Apoptotic Pathway. 2016 Int J Mol Sci pmid:27196894
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Cheng J et al. Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. 2012 Int J Nanomedicine pmid:22745547
Wang L et al. Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. 2012 Int J Nanomedicine pmid:22359456
Yu H et al. Enhancement of solubility and dissolution rate of baicalein, wogonin and oroxylin A extracted from Radix scutellariae. 2017 Int J Pharm pmid:28642200
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Kapoor S Protective effects of wogonin against disease progression in different hepatic pathological conditions. 2017 Int. Immunopharmacol. pmid:28886583
Li HD et al. Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. 2017 Int. Immunopharmacol. pmid:28646664
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Huang GC et al. Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. 2007 Int. Immunopharmacol. pmid:17570322
Lee HW et al. Potent inhibition of monoamine oxidase A by decursin from Angelica gigas Nakai and by wogonin from Scutellaria baicalensis Georgi. 2017 Int. J. Biol. Macromol. pmid:28109809
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Polier G et al. Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263. 2015 Int. J. Cancer pmid:24895203
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Go JH et al. Wogonin suppresses the LPS‑enhanced invasiveness of MDA‑MB‑231 breast cancer cells by inhibiting the 5‑LO/BLT2 cascade. 2018 Int. J. Mol. Med. pmid:30015917
Liu X et al. Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NF‑κB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling. 2016 Int. J. Mol. Med. pmid:27499272
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Lin CC et al. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. 2011 Int. J. Oncol. pmid:21573491
Wang CZ et al. Deglycosylation of wogonoside enhances its anticancer potential. 2018 J Cancer Res Ther pmid:30249874
Lin SJ et al. Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation sann-joong-kuey-jian-tang by high-performance liquid chromatography. 1996 J Chromatogr A pmid:8680588
Li HB and Chen F Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. 2005 J Chromatogr A pmid:15941045
Zhang H et al. Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive. 2006 J Chromatogr A pmid:16952364
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Lim BO Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes. 2003 J Ethnopharmacol pmid:12499072
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Feng J et al. Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. 2010 J Pharm Biomed Anal pmid:20430560
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