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Int J Mol Sci |
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Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. |
2010 |
J Neuroinflammation |
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Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches. |
2010 |
Anal. Chim. Acta |
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Wogonin inhibits osteoclast formation induced by lipopolysaccharide. |
2010 |
Phytother Res |
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Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. |
2010 |
Parkinsons Dis |
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Apoptotic effects of chrysin in human cancer cell lines. |
2010 |
Int J Mol Sci |
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Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. |
2010 |
J Ethnobiol Ethnomed |
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A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. |
2010 |
Chin Med |
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Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers. |
2010 |
J Pharm Biomed Anal |
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2010 |
J Pharm Biomed Anal |
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Traditional Chinese medicine and related active compounds against hepatitis B virus infection. |
2010 |
Biosci Trends |
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Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. |
2010 |
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2010 |
Cancer Invest. |
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Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). |
2010 |
Toxins (Basel) |
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Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. |
2010 |
J Pharm Biomed Anal |
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Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. |
2010 |
J Pharm Biomed Anal |
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On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. |
2010 |
J Chromatogr A |
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2010 Oct-Dec |
Sci Pharm |
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Li Y and Martin RC |
Herbal medicine and hepatocellular carcinoma: applications and challenges. |
2011 |
Evid Based Complement Alternat Med |
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Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel. |
2011 |
Acta Physiol (Oxf) |
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Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity. |
2011 |
Evid Based Complement Alternat Med |
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Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats. |
2011 |
Evid Based Complement Alternat Med |
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Shih YT et al. |
San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells. |
2011 |
Evid Based Complement Alternat Med |
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Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. |
2011 |
Acta Pharmacol. Sin. |
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Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. |
2011 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. |
2011 |
Cell Biol. Toxicol. |
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Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. |
2011 |
J Pharm Biomed Anal |
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Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. |
2011 |
J. Pharmacol. Sci. |
pmid:21606625
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Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. |
2011 |
BMC Neurosci |
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The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. |
2011 |
Int J Mol Sci |
pmid:21340000
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Gao J et al. |
The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. |
2011 |
Toxicol. Appl. Pharmacol. |
pmid:21457722
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Park NI et al. |
Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. |
2011 |
Funct. Integr. Genomics |
pmid:21538138
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Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. |
2011 |
PLoS ONE |
pmid:21779360
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Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. |
2011 |
Nutr Res Pract |
pmid:21779522
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Tan W et al. |
Anti-cancer natural products isolated from chinese medicinal herbs. |
2011 |
Chin Med |
pmid:21777476
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Lin B |
Polyphenols and neuroprotection against ischemia and neurodegeneration. |
2011 |
Mini Rev Med Chem |
pmid:22070681
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Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? |
2011 |
CNS Neurol Disord Drug Targets |
pmid:21222632
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Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. |
2011 |
Biopharm Drug Dispos |
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Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae. |
2011 |
Am. J. Chin. Med. |
pmid:21905290
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Zeng H et al. |
The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway. |
2011 |
J Ethnopharmacol |
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Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9. |
2011 |
J. Pharm. Pharmacol. |
pmid:21235595
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Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study. |
2011 |
Biomed. Chromatogr. |
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Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. |
2011 |
Biomed. Chromatogr. |
pmid:20872909
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Kimura Y and Sumiyoshi M |
Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. |
2011 |
Eur. J. Pharmacol. |
pmid:21549115
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Takahashi H et al. |
Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. |
2011 |
Biochim. Biophys. Acta |
pmid:21596068
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Yang DZ et al. |
Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. |
2011 |
Talanta |
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Li T et al. |
Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. |
2011 |
Eur J Drug Metab Pharmacokinet |
pmid:21713461
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Lee YM et al. |
Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. |
2011 |
J. Cardiovasc. Pharmacol. |
pmid:21436723
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Yu JS and Kim AK |
Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. |
2011 |
Mol. Cells |
pmid:21448585
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Developmental toxicity and genotoxicity studies of wogonin. |
2011 |
Regul. Toxicol. Pharmacol. |
pmid:21459121
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Chen P et al. |
Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. |
2011 |
Toxicology |
pmid:21295103
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Yang L et al. |
Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. |
2011 |
Cancer Sci. |
pmid:21244577
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Chow SE et al. |
Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:21207227
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Chen CY et al. |
Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. |
2011 |
J. Nutr. Biochem. |
pmid:21190831
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Lin CC et al. |
Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. |
2011 |
Int. J. Oncol. |
pmid:21573491
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Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease. |
2011 |
J Inflamm (Lond) |
pmid:22104639
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Jeong JC et al. |
Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. |
2011 |
J. Exp. Clin. Cancer Res. |
pmid:21501525
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Tang H et al. |
The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. |
2011 |
BMC Biol. |
pmid:21418589
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Parajuli P et al. |
Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. |
2011 |
J. Neurooncol. |
pmid:20467782
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Chen FP et al. |
Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002. |
2011 |
Evid Based Complement Alternat Med |
pmid:19339485
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Tayarani-Najaran Z et al. |
Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. |
2011 |
Evid Based Complement Alternat Med |
pmid:20028719
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Enomoto R et al. |
Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. |
2011 |
Cancer Chemother. Pharmacol. |
pmid:20658136
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Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts. |
2011 |
Evid Based Complement Alternat Med |
pmid:19696193
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Wu B et al. |
Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. |
2011 |
BMC Cancer |
pmid:22204275
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Dong P et al. |
Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. |
2011 |
J Ethnopharmacol |
pmid:21855619
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Polier G et al. |
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. |
2011 |
Cell Death Dis |
pmid:21776020
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Pan SY et al. |
New perspectives on chinese herbal medicine (zhong-yao) research and development. |
2011 |
Evid Based Complement Alternat Med |
pmid:21785622
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Su SY and Hsieh CL |
Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. |
2011 |
Chin Med |
pmid:21740583
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Petraglia AL et al. |
Stuck at the bench: Potential natural neuroprotective compounds for concussion. |
2011 |
Surg Neurol Int |
pmid:22059141
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Samarghandian S et al. |
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
pmid:21808878
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Hou YC et al. |
Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. |
2011 |
Planta Med. |
pmid:20957598
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Lee MY et al. |
A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats. |
2011 |
Toxicol Int |
pmid:21976821
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Chen CC et al. |
Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. |
2012 |
PLoS ONE |
pmid:22272328
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Xia Y et al. |
A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. |
2012 |
J Pharm Biomed Anal |
pmid:22906689
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Shao YX et al. |
The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. |
2012 |
Eur. Biophys. J. |
pmid:22228220
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Li J et al. |
Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. |
2012 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:22192416
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Huang KF et al. |
Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. |
2012 |
Int. Immunopharmacol. |
pmid:22182776
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Cheng J et al. |
Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. |
2012 |
Int J Nanomedicine |
pmid:22745547
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He F et al. |
Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. |
2012 |
Oncol. Rep. |
pmid:22665077
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Shih HC and Yang LL |
Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. |
2012 |
Pharm Biol |
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Ma X et al. |
[Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. |
2012 |
Sheng Li Xue Bao |
pmid:22513472
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Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. |
2012 |
Int J Nanomedicine |
pmid:22359456
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Lin CM et al. |
Functional role of wogonin in anti-angiogenesis. |
2012 |
Am. J. Chin. Med. |
pmid:22419433
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Lee DH et al. |
Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. |
2012 |
Cell. Signal. |
pmid:22846543
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Dong LL et al. |
An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. |
2012 |
Food Chem |
pmid:25683416
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Li X et al. |
Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. |
2012 |
Evid Based Complement Alternat Med |
pmid:22235229
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Chow SE et al. |
Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. |
2012 |
J. Cell. Biochem. |
pmid:22689083
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Xia B et al. |
A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. |
2012 |
Mol. Pharm. |
pmid:23033922
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Pham TA et al. |
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. |
2012 |
Bioorg. Med. Chem. Lett. |
pmid:22366656
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Chen S et al. |
Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:23063682
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Qi XF et al. |
Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. |
2012 |
Evid Based Complement Alternat Med |
pmid:21785648
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He H et al. |
Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. |
2012 |
J Pharm Biomed Anal |
pmid:22260968
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Islam MN et al. |
A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. |
2012 |
Nat. Prod. Res. |
pmid:22304335
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Cao XD et al. |
Antitumor constituents from the leaves of Carya cathayensis. |
2012 |
Nat. Prod. Res. |
pmid:22007794
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Lu QY et al. |
Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. |
2012 |
Pancreas |
pmid:22158070
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Li C et al. |
Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. |
2012 |
AAPS J |
pmid:22167378
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Im AR et al. |
Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. |
2012 |
Evid Based Complement Alternat Med |
pmid:22969827
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Ding J et al. |
Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. |
2012 |
J. Biol. Chem. |
pmid:22086925
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Kim JO et al. |
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. |
2012 |
Phytother Res |
pmid:22388989
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Zhang N et al. |
A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. |
2012 |
Evid Based Complement Alternat Med |
pmid:22272213
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