| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen CC et al. | Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. | 2012 | PLoS ONE | pmid:22272328 |
| Xia Y et al. | A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. | 2012 | J Pharm Biomed Anal | pmid:22906689 |
| Shao YX et al. | The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. | 2012 | Eur. Biophys. J. | pmid:22228220 |
| Li J et al. | Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22192416 |
| Huang KF et al. | Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. | 2012 | Int. Immunopharmacol. | pmid:22182776 |
| Cheng J et al. | Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. | 2012 | Int J Nanomedicine | pmid:22745547 |
| He F et al. | Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. | 2012 | Oncol. Rep. | pmid:22665077 |
| Shih HC and Yang LL | Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. | 2012 | Pharm Biol | pmid:22471999 |
| Ma X et al. | [Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. | 2012 | Sheng Li Xue Bao | pmid:22513472 |
| Wang L et al. | Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. | 2012 | Int J Nanomedicine | pmid:22359456 |
| Dong LL et al. | An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. | 2012 | Food Chem | pmid:25683416 |
| Li X et al. | Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. | 2012 | Evid Based Complement Alternat Med | pmid:22235229 |
| Chow SE et al. | Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. | 2012 | J. Cell. Biochem. | pmid:22689083 |
| Tong L et al. | Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. | 2012 | J Pharm Biomed Anal | pmid:22703838 |
| Pham TA et al. | Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22366656 |
| Ha SK et al. | 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. | 2012 | Neuropharmacology | pmid:22465818 |
| Chen S et al. | Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23063682 |
| Li Y et al. | Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22560901 |
| Qi XF et al. | Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. | 2012 | Evid Based Complement Alternat Med | pmid:21785648 |
| Ho FM et al. | Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. | 2012 | J Ethnopharmacol | pmid:22543166 |
| Wilczańska-Barska A et al. | Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. | 2012 | Biotechnol. Lett. | pmid:22639092 |
| He H et al. | Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. | 2012 | J Pharm Biomed Anal | pmid:22260968 |
| Islam MN et al. | A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. | 2012 | Nat. Prod. Res. | pmid:22304335 |
| Cao XD et al. | Antitumor constituents from the leaves of Carya cathayensis. | 2012 | Nat. Prod. Res. | pmid:22007794 |
| Lu QY et al. | Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. | 2012 | Pancreas | pmid:22158070 |
| Li C et al. | Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. | 2012 | AAPS J | pmid:22167378 |
| Ding J et al. | Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. | 2012 | J. Biol. Chem. | pmid:22086925 |
| Kim JO et al. | Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. | 2012 | Phytother Res | pmid:22388989 |
| Zhong Y et al. | Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. | 2013 | Mol. Carcinog. | pmid:22593043 |
| Xu F et al. | The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. | 2013 | J Pharm Sci | pmid:24018852 |
| Oshima N et al. | Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. | 2013 | J Nat Med | pmid:22729955 |
| Yu C et al. | Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. | 2013 | Pharm Biol | pmid:23738852 |
| Wang Y et al. | GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. | 2013 | Toxicol. Lett. | pmid:23872260 |
| Zhao L et al. | Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. | 2013 | Biochem. Cell Biol. | pmid:23859016 |
| Wang F et al. | Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. | 2013 | Toxicology | pmid:23246481 |
| Kimura Y and Sumiyoshi M | Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. | 2013 | Phytomedicine | pmid:23219337 |
| Wang CZ et al. | Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. | 2013 | Int. J. Oncol. | pmid:23337959 |
| Yang L et al. | Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. | 2013 | Apoptosis | pmid:23371323 |
| Song X et al. | Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707765 |
| Zhang M et al. | Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. | 2013 | Life Sci. | pmid:23142241 |
| Chengcheng G et al. | Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. | 2013 | Afr Health Sci | pmid:24250287 |
| Chen XM et al. | Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. | 2013 | PLoS ONE | pmid:24265759 |
| He L et al. | Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. | 2013 | Toxicology | pmid:23907061 |
| Chirumbolo S | Anticancer properties of the flavone wogonin. | 2013 | Toxicology | pmid:23994129 |
| Zhou YQ et al. | [Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. | 2013 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:24490490 |
| Kim MS et al. | Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. | 2013 | Cell Biol. Toxicol. | pmid:23955116 |
| Attia SM et al. | Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. | 2013 | Food Chem. Toxicol. | pmid:23872129 |
| Kim SG et al. | Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas. | 2013 | J Nat Med | pmid:22855402 |
| Kim TW et al. | Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. | 2013 | Planta Med. | pmid:23818268 |
| Lin CC et al. | Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. | 2013 Nov-Dec | In Vivo | pmid:24292576 |