| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xiao JR et al. | Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. | 2014 | J Ocul Pharmacol Ther | pmid:25280175 |
| Kwak S et al. | Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25223693 |
| Li C et al. | Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. | 2014 | Pharm Biol | pmid:24102566 |
| Fong SY et al. | Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. | 2014 | J Pharm Biomed Anal | pmid:24803030 |
| Sikder MA et al. | Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. | 2014 | Phytother Res | pmid:23463646 |
| Bak EJ et al. | Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. | 2014 | Clin Nutr | pmid:23623334 |
| Liu J et al. | Screening of osteoanagenesis-active compounds from Scutellaria baicalensis Georgi by hPDLC/CMC-online-HPLC/MS. | 2014 | Fitoterapia | pmid:24393619 |
| Fong SY and Zuo Z | Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. | 2014 | Xenobiotica | pmid:24168065 |
| Gong WY et al. | Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro. | 2014 | Int. J. Oncol. | pmid:24604573 |
| Wang H et al. | Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. | 2014 | Mol. Carcinog. | pmid:23761018 |
| Huang KF et al. | [Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25039187 |
| Shin HS et al. | Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. | 2014 | Molecules | pmid:24566319 |
| Yeh CH et al. | Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. | 2014 | Environ. Toxicol. | pmid:23362215 |
| Nam KW et al. | The role of wogonin in controlling SOCS3 expression in neuronal cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25035930 |
| Zhang F and Wang G | A review of non-nucleoside anti-hepatitis B virus agents. | 2014 | Eur J Med Chem | pmid:24549242 |
| Yao J et al. | Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. | 2014 | Immunology | pmid:24766487 |
| Zhang Y et al. | V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. | 2014 | Arch. Toxicol. | pmid:23835921 |
| Marsh Z et al. | Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. | 2014 | Phytochemistry | pmid:25236693 |
| Tian SS et al. | Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis. | 2014 | Fitoterapia | pmid:24096161 |
| Yan T et al. | Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. | 2014 | Diagn Pathol | pmid:25432585 |
| Zhao K et al. | Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. | 2014 | PLoS ONE | pmid:25203554 |
| Yang H et al. | Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. | 2014 | Oncotarget | pmid:25149543 |
| Yao J et al. | NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. | 2014 | Cell Death Dis | pmid:24901054 |
| Talbi A et al. | Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. | 2014 | Molecules | pmid:24786691 |
| Xu X et al. | Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway. | 2014 | Biochem. Pharmacol. | pmid:25264278 |
| Hosseinzadeh Z et al. | Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25168590 |
| Ku SK and Bae JS | Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. | 2014 | Fitoterapia | pmid:25020199 |
| Zhao K et al. | Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling. | 2014 | Eur. J. Pharmacol. | pmid:24858369 |
| Qian C et al. | Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells. | 2014 | Free Radic. Res. | pmid:24666416 |
| Zhou M et al. | Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway. | 2014 | Vascul. Pharmacol. | pmid:24534483 |
| Tian J et al. | A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. | 2014 | Drug Deliv | pmid:24215357 |
| Ku SK et al. | Inhibitory effect of baicalin, baicalein and wogonin on secretory group IIA phospholipase A2. | 2015 | Arch. Pharm. Res. | pmid:25564337 |
| Woźniak D et al. | Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix. | 2015 | Nat. Prod. Res. | pmid:25427178 |
| Liu J et al. | Deep Sequencing of the Scutellaria baicalensis Georgi Transcriptome Reveals Flavonoid Biosynthetic Profiling and Organ-Specific Gene Expression. | 2015 | PLoS ONE | pmid:26317778 |
| Aslan E and Adem S | In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. | 2015 | J. Biochem. Mol. Toxicol. | pmid:25388478 |
| Qu JT et al. | Vasodilatory Effect of Wogonin on the Rat Aorta and Its Mechanism Study. | 2015 | Biol. Pharm. Bull. | pmid:26632179 |
| Lu H et al. | Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis. | 2015 | Mol Med Rep | pmid:26398525 |
| Zhang YM et al. | Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. | 2015 | Acta Pharmacol. Sin. | pmid:26073326 |
| Xiao W et al. | Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity. | 2015 | J. Immunother. | pmid:25962106 |
| Huang Y et al. | Wogonin inhibits LPS-induced vascular permeability via suppressing MLCK/MLC pathway. | 2015 | Vascul. Pharmacol. | pmid:25956732 |
| Wang W et al. | Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro. | 2015 | Inflamm. Res. | pmid:25917044 |
| Hu C et al. | Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway. | 2015 | Oncol. Rep. | pmid:25846394 |
| Persson C | Drug-induced death of eosinophils. Promises and pitfalls. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25767918 |
| Ge W et al. | Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway. | 2015 | J. Mol. Neurosci. | pmid:25740014 |
| Tan CX et al. | Activities of wogonin analogs and other flavones against Flavobacterium columnare. | 2015 | Chem. Biodivers. | pmid:25676507 |
| Zhu Y and Wang J | Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer's disease. | 2015 | Neurol. Sci. | pmid:25596147 |
| Boozari M et al. | Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25546119 |
| Chen S et al. | Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. | 2015 | Cell. Mol. Neurobiol. | pmid:25504431 |
| Song X et al. | Wogonin influences vascular permeability via Wnt/β-catenin pathway. | 2015 | Mol. Carcinog. | pmid:24136474 |
| Yeh CH et al. | Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. | 2015 | Toxicol Ind Health | pmid:23592745 |