MeSH term | MeSH ID | Detail |
---|---|---|
Insulin Resistance | D007333 | 99 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tangeretin
MeSH term | MeSH ID | Detail |
---|---|---|
Insulin Resistance | D007333 | 99 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chong SY et al. | Tangeretin sensitizes SGS1-deficient cells by inducing DNA damage. | 2013 | J. Agric. Food Chem. | pmid:23750935 |
Ting Y et al. | Effect of a labile methyl donor on the transformation of 5-demethyltangeretin and the related implication on bioactivity. | 2013 | J. Agric. Food Chem. | pmid:23915315 |
Xu JJ et al. | Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'. | 2014 | J. Agric. Food Chem. | pmid:24377463 |
Ortuño A et al. | Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels. | 2002 | J. Agric. Food Chem. | pmid:11982408 |
Kou G et al. | Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance. | 2018 | J. Agric. Food Chem. | pmid:30369237 |
Lin Y et al. | Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. | 2011 | J. Agric. Food Chem. | pmid:21425871 |
Han S et al. | Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong. | 2010 | J. Agric. Food Chem. | pmid:20698540 |
Stuetz W et al. | Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. | 2010 | J. Agric. Food Chem. | pmid:20420369 |
Zheng G et al. | Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection. | 2009 | J. Agric. Food Chem. | pmid:19722565 |
Aslan E and Adem S | In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. | 2015 | J. Biochem. Mol. Toxicol. | pmid:25388478 |