| MeSH term | MeSH ID | Detail |
|---|---|---|
| Reperfusion Injury | D015427 | 65 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Batenburg AM et al. | Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods. | 2016 | J. Agric. Food Chem. | pmid:26934534 |
| Xu JJ et al. | Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. | 2015 | J. Agric. Food Chem. | pmid:26468759 |
| Liang F et al. | Attenuation of tert-Butyl Hydroperoxide ( t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2-ARE and MAPK Signaling Pathways. | 2018 | J. Agric. Food Chem. | pmid:29871486 |
| Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
| Wang M et al. | Antioxidant Protection of Nobiletin, 5-Demethylnobiletin, Tangeretin, and 5-Demethyltangeretin from Citrus Peel in Saccharomyces cerevisiae. | 2018 | J. Agric. Food Chem. | pmid:29526093 |
| Mertens-Talcott SU et al. | Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells. | 2007 | J. Agric. Food Chem. | pmid:17348674 |
| Kurowska EM and Manthey JA | Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. | 2004 | J. Agric. Food Chem. | pmid:15137829 |
| Manthey JA et al. | Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. | 2011 | J. Agric. Food Chem. | pmid:21133365 |
| MartÃnez Conesa C et al. | Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin. | 2005 | J. Agric. Food Chem. | pmid:16104801 |
| Satsu H et al. | Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals. | 2008 | J. Agric. Food Chem. | pmid:18540626 |
| Adepoju G and Adeyemi T | Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin. | 2010 | J Young Pharm | pmid:21042484 |
| Wang Z et al. | Validated reversed phase LC method for quantitative analysis of polymethoxyflavones in citrus peel extracts. | 2008 | J Sep Sci | pmid:18095294 |
| Zhou DY et al. | UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii. | 2009 | J Pharm Biomed Anal | pmid:19428213 |
| Wang D et al. | Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. | 2007 | J Pharm Biomed Anal | pmid:17367982 |
| Zhou DY et al. | Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry. | 2007 | J Pharm Biomed Anal | pmid:17291708 |
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| Sumbul S et al. | Role of phenolic compounds in peptic ulcer: An overview. | 2011 | J Pharm Bioallied Sci | pmid:21966156 |
| Lee YY et al. | Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia. | 2016 | J Neuroimmune Pharmacol | pmid:26899309 |
| Abe S et al. | Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland. | 2007 | J Med Food | pmid:17472462 |
| Fan K et al. | Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice. | 2007 | J Med Food | pmid:17472461 |
| Sekiguchi H et al. | Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. | 2008 | J Clin Biochem Nutr | pmid:18818744 |
| Zeng SL et al. | Chemicalome and metabolome profiling of polymethoxylated flavonoids in Citri Reticulatae Pericarpium based on an integrated strategy combining background subtraction and modified mass defect filter in a Microsoft Excel Platform. | 2017 | J Chromatogr A | pmid:28619587 |
| Wang X et al. | Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16196149 |
| Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
| Jang SE et al. | Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. | 2013 | Int. Immunopharmacol. | pmid:23938254 |
| Shu Z et al. | Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells. | 2014 | Int. Immunopharmacol. | pmid:24462494 |
| Walle T | Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. | 2009 | Int J Mol Sci | pmid:20087474 |
| Furukawa Y et al. | Isolation and characterization of activators of ERK/MAPK from citrus plants. | 2012 | Int J Mol Sci | pmid:22408427 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
| Vanhoecke BW et al. | A safety study of oral tangeretin and xanthohumol administration to laboratory mice. | 2005 Jan-Feb | In Vivo | pmid:15796161 |
| He YF et al. | Tangeritin inhibits adipogenesis by down-regulating C/EBPα, C/EBPβ, and PPARγ expression in 3T3-L1 fat cells. | 2015 | Genet. Mol. Res. | pmid:26535679 |
| Hazra B et al. | The prospective role of plant products in radiotherapy of cancer: a current overview. | 2011 | Front Pharmacol | pmid:22291649 |
| Fatima A et al. | Protective effect of tangeritin in transgenic Drosophila model of Parkinson's disease. | 2017 | Front Biosci (Elite Ed) | pmid:27814588 |
| Su X and D'Souza DH | Naturally occurring flavonoids against human norovirus surrogates. | 2013 | Food Environ Virol | pmid:23412728 |
| Ho SC and Kuo CT | Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium). | 2014 | Food Chem. Toxicol. | pmid:24955543 |
| Stroheker T et al. | Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. | 2004 | Food Chem. Toxicol. | pmid:15110097 |
| Nielsen SE et al. | Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. | 2000 | Food Chem. Toxicol. | pmid:10930694 |
| Kim H et al. | Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract. | Food Chem. Toxicol. | pmid:20538032 | |
| Delaney B et al. | Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. | 2002 | Food Chem. Toxicol. | pmid:11955667 |
| Delaney B et al. | Immunotoxicity of a standardized citrus polymethoxylated flavone extract. | 2001 | Food Chem. Toxicol. | pmid:11527568 |
| Wan J et al. | Enhancement of physical stability and bioaccessibility of tangeretin by soy protein isolate addition. | 2017 | Food Chem | pmid:27979270 |
| Chen J et al. | Tangeretin-loaded protein nanoparticles fabricated from zein/β-lactoglobulin: preparation, characterization, and functional performance. | 2014 | Food Chem | pmid:24731371 |
| Han S et al. | Simultaneous determination of polymethoxyflavones in Citrus species, Kiyomi tangor and Satsuma mandarin, by high performance liquid chromatography. | 2012 | Food Chem | pmid:23107751 |
| Chen ZT et al. | Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. | 2012 | Food Chem | pmid:22980779 |
| Yang EJ et al. | Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion. | 2013 | Food Chem | pmid:23265538 |
| Jiang Y et al. | Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin. | 2014 | Fitoterapia | pmid:25451794 |
| Van Slambrouck S et al. | Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation. | 2005 | FEBS Lett. | pmid:15757658 |
| Lee DH et al. | Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22194772 |
| Seo J et al. | Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation. | 2011 | Eur. J. Pharmacol. | pmid:22040922 |