| MeSH term | MeSH ID | Detail |
|---|---|---|
| Reperfusion Injury | D015427 | 65 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Semin. Cancer Biol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Arterioscler. Thromb. Vasc. Biol. (1)
- Others (3)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
- Semin. Cancer Biol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Arterioscler. Thromb. Vasc. Biol. (1)
- Others (3)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bracke ME et al. | Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. | 1999 | J. Natl. Cancer Inst. | pmid:10050869 |
| Nguyen TD and Canada AT | Citrus flavonoids stimulate secretion by human colonic T84 cells. | 1993 | J. Nutr. | pmid:8381480 |
| Arivazhagan L and Sorimuthu Pillai S | Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinoma. | 2014 | J. Nutr. Biochem. | pmid:25151216 |
| Akachi T et al. | Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats. | 2010 | J. Nutr. Sci. Vitaminol. | pmid:20354348 |
| Takanaga H et al. | Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10734174 |
| Tominari T et al. | Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. | 2012 | J. Pharmacol. Sci. | pmid:22850615 |
| Miyata Y et al. | Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. | 2011 | Life Sci. | pmid:21295043 |
| Kurowska EM et al. | Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. | 2004 | Lipids | pmid:15134141 |
| Nichols LA et al. | Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes. | 2011 | Lipids Health Dis | pmid:21345233 |
| Roshini A et al. | pH-sensitive tangeretin-ZnO quantum dots exert apoptotic and anti-metastatic effects in metastatic lung cancer cell line. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:30184773 |
| Rodriguez J et al. | Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: relationship between structure and activity. | 2002 | Melanoma Res. | pmid:11930105 |
| Johann S et al. | Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. | 2007 | Mem. Inst. Oswaldo Cruz | pmid:17923995 |
| Charoensinphon N et al. | 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. | 2013 | Mol Nutr Food Res | pmid:23926120 |
| Qiu P et al. | Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. | 2010 | Mol Nutr Food Res | pmid:20397199 |
| Lust S et al. | The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562. | 2010 | Mol Nutr Food Res | pmid:20077418 |
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| Ujiki MB et al. | Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. | 2006 | Mol. Cancer | pmid:17196098 |
| Shih WL et al. | Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. | 2013 | Mol. Carcinog. | pmid:22549898 |
| Kim MS et al. | Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. | 2012 | Mol. Cell. Endocrinol. | pmid:22476082 |
| Ting Y et al. | Viscoelastic Emulsion Improved the Bioaccessibility and Oral Bioavailability of Crystalline Compound: A Mechanistic Study Using in Vitro and in Vivo Models. | 2015 | Mol. Pharm. | pmid:25984595 |
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| Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
| Sun Y et al. | Simultaneous determination of flavonoids in different parts of Citrus reticulata 'Chachi' fruit by high performance liquid chromatography-photodiode array detection. | 2010 | Molecules | pmid:20714303 |
| Lake BG et al. | Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices. | 1999 | Mutat. Res. | pmid:10095132 |
| Rooprai HK et al. | Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro. | 2001 | Neuropathol. Appl. Neurobiol. | pmid:11299000 |
| Datla KP et al. | Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. | 2001 | Neuroreport | pmid:11726811 |
| Chaumontet C et al. | Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. | 1996 | Nutr Cancer | pmid:8910908 |
| Yáñez J et al. | Cytotoxicity and antiproliferative activities of several phenolic compounds against three melanocytes cell lines: relationship between structure and activity. | 2004 | Nutr Cancer | pmid:15489212 |
| Miller EG et al. | Inhibition of oral carcinogenesis by citrus flavonoids. | 2008 | Nutr Cancer | pmid:18444138 |
| Youn K et al. | Polymethoxyflavones: Novel β-Secretase (BACE1) Inhibitors from Citrus Peels. | 2017 | Nutrients | pmid:28869548 |
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| Dong Y et al. | Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways. | 2014 | Oncol. Rep. | pmid:24573532 |
| Zhang X et al. | Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. | 2015 | Oncol. Rep. | pmid:25998143 |
| Yumnam S et al. | Identification of a novel biomarker in tangeretin‑induced cell death in AGS human gastric cancer cells. | 2018 | Oncol. Rep. | pmid:30272339 |
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| Almada-Ruiz E et al. | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits. | 2003 | Pest Manag. Sci. | pmid:14620052 |
| Ohtani H et al. | Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. | 2007 | Pharm. Res. | pmid:17492365 |
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| Nakayama N et al. | Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. | 2011 | Pharmacognosy Res | pmid:22022162 |
| Feng SL et al. | Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function. | 2016 | Pharmacol. Res. | pmid:27058921 |
| Yuan ZW et al. | Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. | 2018 | Pharmacol. Res. | pmid:28958806 |
| Breinholt VM et al. | In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s. | 2003 | Pharmacol. Toxicol. | pmid:12828569 |
| Sundaram R et al. | Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats. | 2014 | Phytomedicine | pmid:24629597 |
| Guo R et al. | Identifying potential quality markers of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC-LTQ-Orbitrap, ADME prediction and network target analysis. | 2018 | Phytomedicine | pmid:29526583 |
| Shi MD et al. | Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. | 2013 | Phytomedicine | pmid:23537747 |
| Choi BK et al. | A polymethoxy flavonoids-rich Citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model. | 2015 | Phytother Res | pmid:26178909 |
| Onda K et al. | Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes. | 2013 | Phytother Res | pmid:22585555 |
| Wu JJ et al. | Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract. | 2013 | Phytother Res | pmid:22678994 |
| Calomme M et al. | Inhibition of bacterial mutagenesis by Citrus flavonoids. | 1996 | Planta Med. | pmid:8693033 |