MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tangeretin
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kandaswami C et al. | Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. | 1992 | Anticancer Drugs | pmid:1450447 |
Vaiyapuri S et al. | Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:24135020 |
Meiyanto E et al. | Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22524801 |
Whitman SC et al. | Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. | 2005 | Atherosclerosis | pmid:15585197 |
Nagase H et al. | Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16253614 |
Quintieri L et al. | Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. | 2008 | Biochem. Pharmacol. | pmid:18191104 |
Chen KH et al. | Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. | 2007 | Biochem. Pharmacol. | pmid:17067555 |
Lakshmi A and Subramanian S | Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7, 12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats. | 2014 | Biochimie | pmid:24299963 |
Eguchi A et al. | Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. | 2007 | Biofactors | pmid:18806314 |
Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |