| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Seo J et al. | Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation. | 2011 | Eur. J. Pharmacol. | pmid:22040922 |
| Nakayama N et al. | Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. | 2011 | Pharmacognosy Res | pmid:22022162 |
| Sumbul S et al. | Role of phenolic compounds in peptic ulcer: An overview. | 2011 | J Pharm Bioallied Sci | pmid:21966156 |
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| Ayala-Zavala JF et al. | Antioxidant enrichment and antimicrobial protection of fresh-cut fruits using their own byproducts: looking for integral exploitation. | 2010 | J. Food Sci. | pmid:21535513 |
| Yang X et al. | Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants. | 2011 | J. Agric. Food Chem. | pmid:21517071 |
| Mulvihill EE et al. | Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. | 2011 | Diabetes | pmid:21471511 |
| Lin Y et al. | Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. | 2011 | J. Agric. Food Chem. | pmid:21425871 |
| Nichols LA et al. | Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes. | 2011 | Lipids Health Dis | pmid:21345233 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
| Miyata Y et al. | Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. | 2011 | Life Sci. | pmid:21295043 |
| Cheng Z et al. | Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K. | 2011 | Br. J. Pharmacol. | pmid:21198542 |
| Manthey JA et al. | Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. | 2011 | J. Agric. Food Chem. | pmid:21133365 |
| Yoon JH et al. | Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation. | 2011 | J. Agric. Food Chem. | pmid:21126077 |
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| Walle T | Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. | 2009 | Int J Mol Sci | pmid:20087474 |
| Lust S et al. | The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562. | 2010 | Mol Nutr Food Res | pmid:20077418 |
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| Arafa el-SA et al. | Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. | 2009 | Cancer Res. | pmid:19903849 |
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| Ionta M et al. | Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction. | 2009 | Cancer Cell Int. | pmid:19678939 |
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| Sekiguchi H et al. | Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. | 2008 | J Clin Biochem Nutr | pmid:18818744 |
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| Ho SC and Lin CC | Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels. | 2008 | J. Agric. Food Chem. | pmid:18683945 |
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| Bracke ME et al. | Plant polyphenolics as anti-invasive cancer agents. | 2008 | Anticancer Agents Med Chem | pmid:18288920 |
| Akao Y et al. | Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. | 2008 | Bioorg. Med. Chem. | pmid:18282757 |