| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
| Surichan S et al. | Tangeretin inhibits the proliferation of human breast cancer cells via CYP1A1/CYP1B1 enzyme induction and CYP1A1/CYP1B1-mediated metabolism to the product 4' hydroxy tangeretin. | 2018 | Toxicol In Vitro | pmid:29626627 |
| Liang F et al. | Attenuation of tert-Butyl Hydroperoxide ( t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2-ARE and MAPK Signaling Pathways. | 2018 | J. Agric. Food Chem. | pmid:29871486 |
| Chen F et al. | Tangeretin inhibits high glucose-induced extracellular matrix accumulation in human glomerular mesangial cells. | 2018 | Biomed. Pharmacother. | pmid:29710524 |
| Guo R et al. | Identifying potential quality markers of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC-LTQ-Orbitrap, ADME prediction and network target analysis. | 2018 | Phytomedicine | pmid:29526583 |
| Kou G et al. | Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance. | 2018 | J. Agric. Food Chem. | pmid:30369237 |
| Yumnam S et al. | Identification of a novel biomarker in tangeretin‑induced cell death in AGS human gastric cancer cells. | 2018 | Oncol. Rep. | pmid:30272339 |
| Roshini A et al. | pH-sensitive tangeretin-ZnO quantum dots exert apoptotic and anti-metastatic effects in metastatic lung cancer cell line. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:30184773 |
| Yamaguchi M et al. | Effects of Cultivation Month and Genetic Background on Phenolic Content of Citrus tachibana Peel. | 2018 | Biol. Pharm. Bull. | pmid:30068877 |
| Yuan ZW et al. | Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. | 2018 | Pharmacol. Res. | pmid:28958806 |
| Wang M et al. | Antioxidant Protection of Nobiletin, 5-Demethylnobiletin, Tangeretin, and 5-Demethyltangeretin from Citrus Peel in Saccharomyces cerevisiae. | 2018 | J. Agric. Food Chem. | pmid:29526093 |
| Liu LL et al. | Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1/Th2/Th17 cytokine balance in neonatal asthmatic mice. | 2017 | Braz. J. Med. Biol. Res. | pmid:28746467 |
| Zeng SL et al. | Chemicalome and metabolome profiling of polymethoxylated flavonoids in Citri Reticulatae Pericarpium based on an integrated strategy combining background subtraction and modified mass defect filter in a Microsoft Excel Platform. | 2017 | J Chromatogr A | pmid:28619587 |
| Johnson EJ et al. | Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice. | 2017 | Biopharm Drug Dispos | pmid:28032362 |
| Wan J et al. | Enhancement of physical stability and bioaccessibility of tangeretin by soy protein isolate addition. | 2017 | Food Chem | pmid:27979270 |
| Eun SH et al. | Tangeretin Inhibits IL-12 Expression and NF-κB Activation in Dendritic Cells and Attenuates Colitis in Mice. | 2017 | Planta Med. | pmid:27806407 |
| Youn K et al. | Polymethoxyflavones: Novel β-Secretase (BACE1) Inhibitors from Citrus Peels. | 2017 | Nutrients | pmid:28869548 |
| Yoshizaki N et al. | A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes. | 2017 | J. Dermatol. Sci. | pmid:28629701 |
| Guo XQ et al. | Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. | 2017 | Adv Med Sci | pmid:28501723 |
| Braidy N et al. | Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease. | 2017 | CNS Neurol Disord Drug Targets | pmid:28474543 |
| Fatima A et al. | Protective effect of tangeritin in transgenic Drosophila model of Parkinson's disease. | 2017 | Front Biosci (Elite Ed) | pmid:27814588 |
| Hagenlocher Y et al. | Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. | 2017 | Eur J Nutr | pmid:27021766 |
| Kuroda Y et al. | Activation of human bitter taste receptors by polymethoxylated flavonoids. | 2016 | Biosci. Biotechnol. Biochem. | pmid:27379685 |
| Ma LL et al. | Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells. | 2016 | Biomed. Pharmacother. | pmid:27261630 |
| Feng SL et al. | Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function. | 2016 | Pharmacol. Res. | pmid:27058921 |
| Batenburg AM et al. | Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods. | 2016 | J. Agric. Food Chem. | pmid:26934534 |
| Lee YY et al. | Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia. | 2016 | J Neuroimmune Pharmacol | pmid:26899309 |
| Li YR et al. | Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. | 2016 | Cancer Biol. Ther. | pmid:26569090 |
| Funaro A et al. | Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin. | 2016 | J. Food Sci. | pmid:27095513 |
| Omar HA et al. | Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis. | 2016 | PLoS ONE | pmid:27031695 |
| Arab HH et al. | Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations. | 2016 | Chem. Biol. Interact. | pmid:27616468 |
| Xu JJ et al. | Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. | 2015 | J. Agric. Food Chem. | pmid:26468759 |
| Choi BK et al. | A polymethoxy flavonoids-rich Citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model. | 2015 | Phytother Res | pmid:26178909 |
| Zhang X et al. | Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. | 2015 | Oncol. Rep. | pmid:25998143 |
| Das A et al. | A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway. | 2015 | Tumour Biol. | pmid:25864108 |
| Periyasamy K et al. | Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats. | 2015 | Cancer Chemother. Pharmacol. | pmid:25431347 |
| Aslan E and Adem S | In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. | 2015 | J. Biochem. Mol. Toxicol. | pmid:25388478 |
| Sawadogo WR et al. | Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3',4',5'-Pentamethoxyflavone Isolated from Lantana ukambensis. | 2015 | Nutrients | pmid:26690473 |
| Ting Y et al. | Viscoelastic Emulsion Improved the Bioaccessibility and Oral Bioavailability of Crystalline Compound: A Mechanistic Study Using in Vitro and in Vivo Models. | 2015 | Mol. Pharm. | pmid:25984595 |
| He YF et al. | Tangeritin inhibits adipogenesis by down-regulating C/EBPα, C/EBPβ, and PPARγ expression in 3T3-L1 fat cells. | 2015 | Genet. Mol. Res. | pmid:26535679 |
| Lakshmi A and Subramanian SP | Tangeretin ameliorates oxidative stress in the renal tissues of rats with experimental breast cancer induced by 7,12-dimethylbenz[a]anthracene. | 2014 | Toxicol. Lett. | pmid:24995432 |
| Lakshmi A and Subramanian S | Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7, 12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats. | 2014 | Biochimie | pmid:24299963 |
| Xu JJ et al. | Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'. | 2014 | J. Agric. Food Chem. | pmid:24377463 |
| Dong Y et al. | Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways. | 2014 | Oncol. Rep. | pmid:24573532 |
| Shu Z et al. | Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells. | 2014 | Int. Immunopharmacol. | pmid:24462494 |
| Jiang Y et al. | Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin. | 2014 | Fitoterapia | pmid:25451794 |
| Arivazhagan L and Sorimuthu Pillai S | Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinoma. | 2014 | J. Nutr. Biochem. | pmid:25151216 |
| Ho SC and Kuo CT | Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium). | 2014 | Food Chem. Toxicol. | pmid:24955543 |
| Wang J et al. | Pro-apoptotic effects of the novel tangeretin derivate 5-acetyl-6,7,8,4'-tetramethylnortangeretin on MCF-7 breast cancer cells. | 2014 | Cell Biochem. Biophys. | pmid:24938898 |
| Chen J et al. | Tangeretin-loaded protein nanoparticles fabricated from zein/β-lactoglobulin: preparation, characterization, and functional performance. | 2014 | Food Chem | pmid:24731371 |
| Sundaram R et al. | Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats. | 2014 | Phytomedicine | pmid:24629597 |
| Li ZH et al. | [Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC]. | 2013 | Zhong Yao Cai | pmid:23750404 |
| Chong SY et al. | Tangeretin sensitizes SGS1-deficient cells by inducing DNA damage. | 2013 | J. Agric. Food Chem. | pmid:23750935 |
| Jang SE et al. | Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. | 2013 | Int. Immunopharmacol. | pmid:23938254 |
| Su X and D'Souza DH | Naturally occurring flavonoids against human norovirus surrogates. | 2013 | Food Environ Virol | pmid:23412728 |
| Vaiyapuri S et al. | Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:24135020 |
| Charoensinphon N et al. | 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. | 2013 | Mol Nutr Food Res | pmid:23926120 |
| Ting Y et al. | Effect of a labile methyl donor on the transformation of 5-demethyltangeretin and the related implication on bioactivity. | 2013 | J. Agric. Food Chem. | pmid:23915315 |
| Sun Y et al. | Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. | 2013 | J. Food Sci. | pmid:23301602 |
| Shi MD et al. | Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. | 2013 | Phytomedicine | pmid:23537747 |
| Onda K et al. | Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes. | 2013 | Phytother Res | pmid:22585555 |
| Shih WL et al. | Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. | 2013 | Mol. Carcinog. | pmid:22549898 |
| Wu JJ et al. | Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract. | 2013 | Phytother Res | pmid:22678994 |
| Yang EJ et al. | Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion. | 2013 | Food Chem | pmid:23265538 |
| Kim GS et al. | Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. | 2012 | BMC Complement Altern Med | pmid:22471389 |
| Walsky RL et al. | Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. | 2012 | Drug Metab. Dispos. | pmid:22357286 |
| Mulvihill EE and Huff MW | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation. | 2012 | PPAR Res | pmid:22701469 |
| Lee DH et al. | Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22194772 |
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| Kim MS et al. | Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. | 2012 | Mol. Cell. Endocrinol. | pmid:22476082 |
| Tominari T et al. | Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. | 2012 | J. Pharmacol. Sci. | pmid:22850615 |
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| Vila-Real H et al. | Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. | 2011 | Enzyme Res | pmid:21941631 |
| Nichols LA et al. | Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes. | 2011 | Lipids Health Dis | pmid:21345233 |
| Lai HC et al. | Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. | 2011 | PLoS ONE | pmid:22140566 |
| Hazra B et al. | The prospective role of plant products in radiotherapy of cancer: a current overview. | 2011 | Front Pharmacol | pmid:22291649 |
| Lin Y et al. | Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. | 2011 | J. Agric. Food Chem. | pmid:21425871 |
| Manthey JA et al. | Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. | 2011 | J. Agric. Food Chem. | pmid:21133365 |
| Yoon JH et al. | Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation. | 2011 | J. Agric. Food Chem. | pmid:21126077 |
| Miyata Y et al. | Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. | 2011 | Life Sci. | pmid:21295043 |
| Cheng Z et al. | Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K. | 2011 | Br. J. Pharmacol. | pmid:21198542 |
| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
| Nakayama N et al. | Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. | 2011 | Pharmacognosy Res | pmid:22022162 |
| Seo J et al. | Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation. | 2011 | Eur. J. Pharmacol. | pmid:22040922 |
| Chahar MK et al. | Flavonoids: A versatile source of anticancer drugs. | 2011 | Pharmacogn Rev | pmid:22096313 |
| Tistaert C et al. | Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination. | 2011 | Anal. Chim. Acta | pmid:21962354 |
| Oshitari T et al. | B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production. | 2011 | Bioorg. Med. Chem. | pmid:22047798 |