| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ghali A et al. | Thrombocytopenic Purpura Associated with Dietary Supplements Containing Citrus Flavonoids. | Therapie | pmid:26242500 | |
| pmid: | ||||
| Kim H et al. | Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract. | Food Chem. Toxicol. | pmid:20538032 | |
| Mareel MM and De Mets M | Anti-invasive activities of experimental chemotherapeutic agents. | 1989 | Crit. Rev. Oncol. Hematol. | pmid:2686699 |
| Bracke ME et al. | The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro. | 1989 May-Jun | Clin. Exp. Metastasis | pmid:2924447 |
| Kandaswami C et al. | Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. | 1991 | Cancer Lett. | pmid:1998943 |
| Bracke M et al. | Effect of catechins and citrus flavonoids on invasion in vitro. | 1991 Jan-Feb | Clin. Exp. Metastasis | pmid:1901781 |
| Kandaswami C et al. | Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. | 1992 | Anticancer Drugs | pmid:1450447 |
| Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
| Nguyen TD and Canada AT | Citrus flavonoids stimulate secretion by human colonic T84 cells. | 1993 | J. Nutr. | pmid:8381480 |
| Canivenc-Lavier MC et al. | Evidence for tangeretin O-demethylation by rat and human liver microsomes. | 1993 | Xenobiotica | pmid:8498088 |
| Chaumontet C et al. | Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells. | 1994 | Carcinogenesis | pmid:7955073 |
| Hirano T et al. | Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. | 1995 | Br. J. Cancer | pmid:8519648 |
| Obermeier MT et al. | Effects of bioflavonoids on hepatic P450 activities. | 1995 | Xenobiotica | pmid:7483658 |
| Canivenc-Lavier MC et al. | Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. | 1996 | Toxicology | pmid:8931757 |
| Chaumontet C et al. | Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. | 1996 | Nutr Cancer | pmid:8910908 |
| Canivenc-Lavier MC et al. | Differential effects of nonhydroxylated flavonoids as inducers of cytochrome P450 1A and 2B isozymes in rat liver. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8619243 |
| Bracke ME et al. | The E-cadherin/catenin complex in invasion and metastasis. | 1996 | Curr. Top. Microbiol. Immunol. | pmid:8814984 |
| Calomme M et al. | Inhibition of bacterial mutagenesis by Citrus flavonoids. | 1996 | Planta Med. | pmid:8693033 |
| Chaumontet C et al. | Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells. | 1997 | Cancer Lett. | pmid:9103293 |
| Lake BG et al. | Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices. | 1999 | Mutat. Res. | pmid:10095132 |
| Rooprai HK et al. | Influence of putative antiinvasive agents on matrix metalloproteinase secretion by human neoplastic glia in vitro. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10415799 |
| Bracke ME et al. | Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. | 1999 | J. Natl. Cancer Inst. | pmid:10050869 |
| Breinholt V et al. | Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. | 1999 | Xenobiotica | pmid:10647909 |
| Nielsen SE et al. | Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. | 2000 | Food Chem. Toxicol. | pmid:10930694 |
| Takanaga H et al. | Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10734174 |
| Guo XL et al. | [Studies on chemical constituents of processed green tangerine peel]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12212096 |
| Backman JT et al. | Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. | 2000 | Clin. Pharmacol. Ther. | pmid:10801247 |
| Depypere HT et al. | Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer. | 2000 | Eur. J. Cancer | pmid:11056327 |
| Ikegawa T et al. | Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. | 2000 | Cancer Lett. | pmid:11098080 |
| Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
| Rong H et al. | 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. | 2001 | Eur. J. Cell Biol. | pmid:11675933 |
| Datla KP et al. | Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. | 2001 | Neuroreport | pmid:11726811 |
| Rooprai HK et al. | Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro. | 2001 | Neuropathol. Appl. Neurobiol. | pmid:11299000 |
| Delaney B et al. | Immunotoxicity of a standardized citrus polymethoxylated flavone extract. | 2001 | Food Chem. Toxicol. | pmid:11527568 |
| Ortuño A et al. | Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels. | 2002 | J. Agric. Food Chem. | pmid:11982408 |
| Williams JA et al. | Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:12386134 |
| Wang MS et al. | Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol. | 2002 | Acta Pharmacol. Sin. | pmid:11860745 |
| Brack ME et al. | The citrus methoxyflavone tangeretin affects human cell-cell interactions. | 2002 | Adv. Exp. Med. Biol. | pmid:12083457 |
| Pan MH et al. | Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. | 2002 | Carcinogenesis | pmid:12376477 |
| Delaney B et al. | Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. | 2002 | Food Chem. Toxicol. | pmid:11955667 |
| Rodriguez J et al. | Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: relationship between structure and activity. | 2002 | Melanoma Res. | pmid:11930105 |
| Almada-Ruiz E et al. | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits. | 2003 | Pest Manag. Sci. | pmid:14620052 |
| Breinholt VM et al. | In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s. | 2003 | Pharmacol. Toxicol. | pmid:12828569 |
| Nogata Y et al. | Effect of extraction method on the concentrations of selected bioactive compounds in mandarin juice. | 2003 | J. Agric. Food Chem. | pmid:14640582 |
| Stroheker T et al. | Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. | 2003 Jul-Aug | Reprod. Toxicol. | pmid:12849853 |
| Soars MG et al. | An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes. | 2004 | Drug Metab. Dispos. | pmid:14709631 |
| Kurowska EM et al. | Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. | 2004 | Lipids | pmid:15134141 |
| Liu L et al. | Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS. | 2004 | Chem. Pharm. Bull. | pmid:15516749 |
| Honda Y et al. | Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. | 2004 | Br. J. Pharmacol. | pmid:15504753 |