| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chaumontet C et al. | Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells. | 1994 | Carcinogenesis | pmid:7955073 |
| Pan MH et al. | Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. | 2002 | Carcinogenesis | pmid:12376477 |
| Wang J et al. | Pro-apoptotic effects of the novel tangeretin derivate 5-acetyl-6,7,8,4'-tetramethylnortangeretin on MCF-7 breast cancer cells. | 2014 | Cell Biochem. Biophys. | pmid:24938898 |
| Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
| Arab HH et al. | Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations. | 2016 | Chem. Biol. Interact. | pmid:27616468 |
| Liu L et al. | Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS. | 2004 | Chem. Pharm. Bull. | pmid:15516749 |
| Bracke M et al. | Effect of catechins and citrus flavonoids on invasion in vitro. | 1991 Jan-Feb | Clin. Exp. Metastasis | pmid:1901781 |
| Bracke ME et al. | The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro. | 1989 May-Jun | Clin. Exp. Metastasis | pmid:2924447 |
| Backman JT et al. | Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. | 2000 | Clin. Pharmacol. Ther. | pmid:10801247 |
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| Malemud CJ | Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways. | 2007 | Curr Opin Pharmacol | pmid:17398158 |
| Bracke ME et al. | The E-cadherin/catenin complex in invasion and metastasis. | 1996 | Curr. Top. Microbiol. Immunol. | pmid:8814984 |
| Mulvihill EE et al. | Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. | 2011 | Diabetes | pmid:21471511 |
| Soars MG et al. | An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes. | 2004 | Drug Metab. Dispos. | pmid:14709631 |
| Walle UK and Walle T | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. | 2007 | Drug Metab. Dispos. | pmid:17709371 |
| Williams JA et al. | Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:12386134 |
| Walsky RL et al. | Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. | 2012 | Drug Metab. Dispos. | pmid:22357286 |
| Vila-Real H et al. | Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. | 2011 | Enzyme Res | pmid:21941631 |
| Hagenlocher Y et al. | Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. | 2017 | Eur J Nutr | pmid:27021766 |
| Depypere HT et al. | Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer. | 2000 | Eur. J. Cancer | pmid:11056327 |
| Rong H et al. | 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. | 2001 | Eur. J. Cell Biol. | pmid:11675933 |
| Seo J et al. | Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation. | 2011 | Eur. J. Pharmacol. | pmid:22040922 |
| Lee DH et al. | Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22194772 |
| Van Slambrouck S et al. | Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation. | 2005 | FEBS Lett. | pmid:15757658 |
| Jiang Y et al. | Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin. | 2014 | Fitoterapia | pmid:25451794 |
| Wan J et al. | Enhancement of physical stability and bioaccessibility of tangeretin by soy protein isolate addition. | 2017 | Food Chem | pmid:27979270 |
| Chen J et al. | Tangeretin-loaded protein nanoparticles fabricated from zein/β-lactoglobulin: preparation, characterization, and functional performance. | 2014 | Food Chem | pmid:24731371 |
| Han S et al. | Simultaneous determination of polymethoxyflavones in Citrus species, Kiyomi tangor and Satsuma mandarin, by high performance liquid chromatography. | 2012 | Food Chem | pmid:23107751 |
| Chen ZT et al. | Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. | 2012 | Food Chem | pmid:22980779 |
| Yang EJ et al. | Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion. | 2013 | Food Chem | pmid:23265538 |
| Ho SC and Kuo CT | Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium). | 2014 | Food Chem. Toxicol. | pmid:24955543 |
| Stroheker T et al. | Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. | 2004 | Food Chem. Toxicol. | pmid:15110097 |
| Nielsen SE et al. | Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. | 2000 | Food Chem. Toxicol. | pmid:10930694 |
| Kim H et al. | Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract. | Food Chem. Toxicol. | pmid:20538032 | |
| Delaney B et al. | Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. | 2002 | Food Chem. Toxicol. | pmid:11955667 |
| Delaney B et al. | Immunotoxicity of a standardized citrus polymethoxylated flavone extract. | 2001 | Food Chem. Toxicol. | pmid:11527568 |
| Su X and D'Souza DH | Naturally occurring flavonoids against human norovirus surrogates. | 2013 | Food Environ Virol | pmid:23412728 |
| Fatima A et al. | Protective effect of tangeritin in transgenic Drosophila model of Parkinson's disease. | 2017 | Front Biosci (Elite Ed) | pmid:27814588 |
| Hazra B et al. | The prospective role of plant products in radiotherapy of cancer: a current overview. | 2011 | Front Pharmacol | pmid:22291649 |
| He YF et al. | Tangeritin inhibits adipogenesis by down-regulating C/EBPα, C/EBPβ, and PPARγ expression in 3T3-L1 fat cells. | 2015 | Genet. Mol. Res. | pmid:26535679 |
| Vanhoecke BW et al. | A safety study of oral tangeretin and xanthohumol administration to laboratory mice. | 2005 Jan-Feb | In Vivo | pmid:15796161 |
| Walle T | Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. | 2009 | Int J Mol Sci | pmid:20087474 |
| Furukawa Y et al. | Isolation and characterization of activators of ERK/MAPK from citrus plants. | 2012 | Int J Mol Sci | pmid:22408427 |
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| Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
| Jang SE et al. | Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. | 2013 | Int. Immunopharmacol. | pmid:23938254 |
| Shu Z et al. | Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells. | 2014 | Int. Immunopharmacol. | pmid:24462494 |
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| Zeng SL et al. | Chemicalome and metabolome profiling of polymethoxylated flavonoids in Citri Reticulatae Pericarpium based on an integrated strategy combining background subtraction and modified mass defect filter in a Microsoft Excel Platform. | 2017 | J Chromatogr A | pmid:28619587 |