| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lakshmi A and Subramanian SP | Tangeretin ameliorates oxidative stress in the renal tissues of rats with experimental breast cancer induced by 7,12-dimethylbenz[a]anthracene. | 2014 | Toxicol. Lett. | pmid:24995432 |
| Li ZH et al. | [Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC]. | 2013 | Zhong Yao Cai | pmid:23750404 |
| Chong SY et al. | Tangeretin sensitizes SGS1-deficient cells by inducing DNA damage. | 2013 | J. Agric. Food Chem. | pmid:23750935 |
| Jang SE et al. | Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. | 2013 | Int. Immunopharmacol. | pmid:23938254 |
| Su X and D'Souza DH | Naturally occurring flavonoids against human norovirus surrogates. | 2013 | Food Environ Virol | pmid:23412728 |
| Vaiyapuri S et al. | Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:24135020 |
| Charoensinphon N et al. | 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. | 2013 | Mol Nutr Food Res | pmid:23926120 |
| Ting Y et al. | Effect of a labile methyl donor on the transformation of 5-demethyltangeretin and the related implication on bioactivity. | 2013 | J. Agric. Food Chem. | pmid:23915315 |
| Sun Y et al. | Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. | 2013 | J. Food Sci. | pmid:23301602 |
| Shi MD et al. | Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. | 2013 | Phytomedicine | pmid:23537747 |
| Onda K et al. | Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes. | 2013 | Phytother Res | pmid:22585555 |
| Shih WL et al. | Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. | 2013 | Mol. Carcinog. | pmid:22549898 |
| Wu JJ et al. | Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract. | 2013 | Phytother Res | pmid:22678994 |
| Yang EJ et al. | Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion. | 2013 | Food Chem | pmid:23265538 |
| Kim GS et al. | Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. | 2012 | BMC Complement Altern Med | pmid:22471389 |
| Walsky RL et al. | Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. | 2012 | Drug Metab. Dispos. | pmid:22357286 |
| Mulvihill EE and Huff MW | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation. | 2012 | PPAR Res | pmid:22701469 |
| Lee DH et al. | Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22194772 |
| Furukawa Y et al. | Isolation and characterization of activators of ERK/MAPK from citrus plants. | 2012 | Int J Mol Sci | pmid:22408427 |
| Weng CJ and Yen GC | Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. | 2012 | Cancer Metastasis Rev. | pmid:22314287 |
| Han S et al. | Simultaneous determination of polymethoxyflavones in Citrus species, Kiyomi tangor and Satsuma mandarin, by high performance liquid chromatography. | 2012 | Food Chem | pmid:23107751 |
| Asikin Y et al. | The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines. | 2012 | J. Agric. Food Chem. | pmid:22804782 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Meiyanto E et al. | Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22524801 |
| Kostrzewa-Susłow E and Janeczko T | Microbial transformations of 7-hydroxyflavanone. | 2012 | ScientificWorldJournal | pmid:22654578 |
| Kim MS et al. | Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. | 2012 | Mol. Cell. Endocrinol. | pmid:22476082 |
| Tominari T et al. | Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. | 2012 | J. Pharmacol. Sci. | pmid:22850615 |
| Chen ZT et al. | Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. | 2012 | Food Chem | pmid:22980779 |
| Chen HF et al. | Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS. | 2012 | J Pharm Biomed Anal | pmid:22071443 |
| Wesołowska O et al. | Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants. | 2012 | J. Nat. Prod. | pmid:23137376 |
| Yang X et al. | Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants. | 2011 | J. Agric. Food Chem. | pmid:21517071 |
| Mulvihill EE et al. | Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. | 2011 | Diabetes | pmid:21471511 |
| Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
| Sumbul S et al. | Role of phenolic compounds in peptic ulcer: An overview. | 2011 | J Pharm Bioallied Sci | pmid:21966156 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Vila-Real H et al. | Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. | 2011 | Enzyme Res | pmid:21941631 |
| Nichols LA et al. | Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes. | 2011 | Lipids Health Dis | pmid:21345233 |
| Lai HC et al. | Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. | 2011 | PLoS ONE | pmid:22140566 |
| Hazra B et al. | The prospective role of plant products in radiotherapy of cancer: a current overview. | 2011 | Front Pharmacol | pmid:22291649 |
| Lin Y et al. | Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. | 2011 | J. Agric. Food Chem. | pmid:21425871 |
| Manthey JA et al. | Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. | 2011 | J. Agric. Food Chem. | pmid:21133365 |
| Yoon JH et al. | Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation. | 2011 | J. Agric. Food Chem. | pmid:21126077 |
| Miyata Y et al. | Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. | 2011 | Life Sci. | pmid:21295043 |
| Cheng Z et al. | Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K. | 2011 | Br. J. Pharmacol. | pmid:21198542 |
| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
| Nakayama N et al. | Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. | 2011 | Pharmacognosy Res | pmid:22022162 |
| Seo J et al. | Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation. | 2011 | Eur. J. Pharmacol. | pmid:22040922 |
| Chahar MK et al. | Flavonoids: A versatile source of anticancer drugs. | 2011 | Pharmacogn Rev | pmid:22096313 |
| Tistaert C et al. | Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination. | 2011 | Anal. Chim. Acta | pmid:21962354 |
| Oshitari T et al. | B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production. | 2011 | Bioorg. Med. Chem. | pmid:22047798 |