Tangeretin

Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tangeretin?

Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tangeretin

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Lung Neoplasms D008175 171 associated lipids
Reperfusion Injury D015427 65 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Parkinson Disease D010300 53 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Tangeretin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tangeretin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tangeretin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tangeretin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Tangeretin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tangeretin?

Mouse Model

Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).

Transgenic Model

Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tangeretin

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Per page 10 20 50 100 | Total 222
Authors Title Published Journal PubMed Link
Sundaram R et al. Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats. 2014 Phytomedicine pmid:24629597
Li ZH et al. [Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC]. 2013 Zhong Yao Cai pmid:23750404
Chong SY et al. Tangeretin sensitizes SGS1-deficient cells by inducing DNA damage. 2013 J. Agric. Food Chem. pmid:23750935
Jang SE et al. Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. 2013 Int. Immunopharmacol. pmid:23938254
Su X and D'Souza DH Naturally occurring flavonoids against human norovirus surrogates. 2013 Food Environ Virol pmid:23412728
Vaiyapuri S et al. Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling. 2013 Arterioscler. Thromb. Vasc. Biol. pmid:24135020
Charoensinphon N et al. 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. 2013 Mol Nutr Food Res pmid:23926120
Ting Y et al. Effect of a labile methyl donor on the transformation of 5-demethyltangeretin and the related implication on bioactivity. 2013 J. Agric. Food Chem. pmid:23915315
Sun Y et al. Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. 2013 J. Food Sci. pmid:23301602
Shi MD et al. Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. 2013 Phytomedicine pmid:23537747
Onda K et al. Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes. 2013 Phytother Res pmid:22585555
Shih WL et al. Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. 2013 Mol. Carcinog. pmid:22549898
Wu JJ et al. Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract. 2013 Phytother Res pmid:22678994
Yang EJ et al. Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion. 2013 Food Chem pmid:23265538
Kim GS et al. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. 2012 BMC Complement Altern Med pmid:22471389
Walsky RL et al. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. 2012 Drug Metab. Dispos. pmid:22357286
Mulvihill EE and Huff MW Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation. 2012 PPAR Res pmid:22701469
Lee DH et al. Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. 2012 Evid Based Complement Alternat Med pmid:22194772
Furukawa Y et al. Isolation and characterization of activators of ERK/MAPK from citrus plants. 2012 Int J Mol Sci pmid:22408427
Weng CJ and Yen GC Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. 2012 Cancer Metastasis Rev. pmid:22314287
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Meiyanto E et al. Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents. 2012 Asian Pac. J. Cancer Prev. pmid:22524801
Kostrzewa-Susłow E and Janeczko T Microbial transformations of 7-hydroxyflavanone. 2012 ScientificWorldJournal pmid:22654578
Kim MS et al. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. 2012 Mol. Cell. Endocrinol. pmid:22476082
Tominari T et al. Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. 2012 J. Pharmacol. Sci. pmid:22850615
Chen ZT et al. Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. 2012 Food Chem pmid:22980779
Chen HF et al. Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS. 2012 J Pharm Biomed Anal pmid:22071443
Wesołowska O et al. Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants. 2012 J. Nat. Prod. pmid:23137376
Cao H et al. Binding Citrus flavanones to human serum albumin: effect of structure on affinity. 2011 Mol. Biol. Rep. pmid:20878474
Yang X et al. Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants. 2011 J. Agric. Food Chem. pmid:21517071
Mulvihill EE et al. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. 2011 Diabetes pmid:21471511
Kyselova Z Toxicological aspects of the use of phenolic compounds in disease prevention. 2011 Interdiscip Toxicol pmid:22319251
Sumbul S et al. Role of phenolic compounds in peptic ulcer: An overview. 2011 J Pharm Bioallied Sci pmid:21966156
Mazzio EA et al. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. 2011 Int J Mol Sci pmid:21340000
Vila-Real H et al. Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. 2011 Enzyme Res pmid:21941631
Nichols LA et al. Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes. 2011 Lipids Health Dis pmid:21345233
Lai HC et al. Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. 2011 PLoS ONE pmid:22140566
Hazra B et al. The prospective role of plant products in radiotherapy of cancer: a current overview. 2011 Front Pharmacol pmid:22291649
Lin Y et al. Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. 2011 J. Agric. Food Chem. pmid:21425871
Manthey JA et al. Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. 2011 J. Agric. Food Chem. pmid:21133365
Yoon JH et al. Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation. 2011 J. Agric. Food Chem. pmid:21126077
Miyata Y et al. Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. 2011 Life Sci. pmid:21295043
Cheng Z et al. Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K. 2011 Br. J. Pharmacol. pmid:21198542
Wu HY et al. Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. 2011 J. Agric. Food Chem. pmid:21314126
Nakayama N et al. Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. 2011 Pharmacognosy Res pmid:22022162
Chahar MK et al. Flavonoids: A versatile source of anticancer drugs. 2011 Pharmacogn Rev pmid:22096313
Tistaert C et al. Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination. 2011 Anal. Chim. Acta pmid:21962354
Oshitari T et al. B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production. 2011 Bioorg. Med. Chem. pmid:22047798