| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li YR et al. | Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. | 2016 | Cancer Biol. Ther. | pmid:26569090 |
| Ionta M et al. | Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction. | 2009 | Cancer Cell Int. | pmid:19678939 |
| Periyasamy K et al. | Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats. | 2015 | Cancer Chemother. Pharmacol. | pmid:25431347 |
| Ishii K et al. | Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | 2010 | Cancer Invest. | pmid:19863351 |
| Chaumontet C et al. | Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells. | 1997 | Cancer Lett. | pmid:9103293 |
| Kandaswami C et al. | Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. | 1991 | Cancer Lett. | pmid:1998943 |
| Ikegawa T et al. | Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. | 2000 | Cancer Lett. | pmid:11098080 |
| Morley KL et al. | Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. | 2007 | Cancer Lett. | pmid:17197076 |
| Weng CJ and Yen GC | Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. | 2012 | Cancer Metastasis Rev. | pmid:22314287 |
| Arafa el-SA et al. | Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. | 2009 | Cancer Res. | pmid:19903849 |
| Chaumontet C et al. | Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells. | 1994 | Carcinogenesis | pmid:7955073 |
| Pan MH et al. | Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. | 2002 | Carcinogenesis | pmid:12376477 |
| Wang J et al. | Pro-apoptotic effects of the novel tangeretin derivate 5-acetyl-6,7,8,4'-tetramethylnortangeretin on MCF-7 breast cancer cells. | 2014 | Cell Biochem. Biophys. | pmid:24938898 |
| Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
| Arab HH et al. | Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations. | 2016 | Chem. Biol. Interact. | pmid:27616468 |
| Liu L et al. | Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS. | 2004 | Chem. Pharm. Bull. | pmid:15516749 |
| Bracke M et al. | Effect of catechins and citrus flavonoids on invasion in vitro. | 1991 Jan-Feb | Clin. Exp. Metastasis | pmid:1901781 |
| Bracke ME et al. | The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro. | 1989 May-Jun | Clin. Exp. Metastasis | pmid:2924447 |
| Backman JT et al. | Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. | 2000 | Clin. Pharmacol. Ther. | pmid:10801247 |
| Braidy N et al. | Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease. | 2017 | CNS Neurol Disord Drug Targets | pmid:28474543 |