| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang X et al. | Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16196149 |
| Sekiguchi H et al. | Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. | 2008 | J Clin Biochem Nutr | pmid:18818744 |
| Abe S et al. | Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland. | 2007 | J Med Food | pmid:17472462 |
| Fan K et al. | Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice. | 2007 | J Med Food | pmid:17472461 |
| Lee YY et al. | Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia. | 2016 | J Neuroimmune Pharmacol | pmid:26899309 |
| Sumbul S et al. | Role of phenolic compounds in peptic ulcer: An overview. | 2011 | J Pharm Bioallied Sci | pmid:21966156 |
| Zhou DY et al. | UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii. | 2009 | J Pharm Biomed Anal | pmid:19428213 |
| Wang D et al. | Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. | 2007 | J Pharm Biomed Anal | pmid:17367982 |
| Zhou DY et al. | Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry. | 2007 | J Pharm Biomed Anal | pmid:17291708 |
| Chen HF et al. | Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS. | 2012 | J Pharm Biomed Anal | pmid:22071443 |
| Wang Z et al. | Validated reversed phase LC method for quantitative analysis of polymethoxyflavones in citrus peel extracts. | 2008 | J Sep Sci | pmid:18095294 |
| Adepoju G and Adeyemi T | Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin. | 2010 | J Young Pharm | pmid:21042484 |
| Chong SY et al. | Tangeretin sensitizes SGS1-deficient cells by inducing DNA damage. | 2013 | J. Agric. Food Chem. | pmid:23750935 |
| del RÃo JA et al. | Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora. | 2004 | J. Agric. Food Chem. | pmid:15053528 |
| Ting Y et al. | Effect of a labile methyl donor on the transformation of 5-demethyltangeretin and the related implication on bioactivity. | 2013 | J. Agric. Food Chem. | pmid:23915315 |
| Xu JJ et al. | Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'. | 2014 | J. Agric. Food Chem. | pmid:24377463 |
| Batenburg AM et al. | Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods. | 2016 | J. Agric. Food Chem. | pmid:26934534 |
| Xu JJ et al. | Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. | 2015 | J. Agric. Food Chem. | pmid:26468759 |
| Ortuño A et al. | Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels. | 2002 | J. Agric. Food Chem. | pmid:11982408 |
| Yang X et al. | Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants. | 2011 | J. Agric. Food Chem. | pmid:21517071 |
| Liang F et al. | Attenuation of tert-Butyl Hydroperoxide ( t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2-ARE and MAPK Signaling Pathways. | 2018 | J. Agric. Food Chem. | pmid:29871486 |
| Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
| Kou G et al. | Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance. | 2018 | J. Agric. Food Chem. | pmid:30369237 |
| Wang M et al. | Antioxidant Protection of Nobiletin, 5-Demethylnobiletin, Tangeretin, and 5-Demethyltangeretin from Citrus Peel in Saccharomyces cerevisiae. | 2018 | J. Agric. Food Chem. | pmid:29526093 |
| Lin Y et al. | Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. | 2011 | J. Agric. Food Chem. | pmid:21425871 |
| Han S et al. | Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong. | 2010 | J. Agric. Food Chem. | pmid:20698540 |
| Stuetz W et al. | Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. | 2010 | J. Agric. Food Chem. | pmid:20420369 |
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| Asikin Y et al. | The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines. | 2012 | J. Agric. Food Chem. | pmid:22804782 |
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| Nogata Y et al. | Effect of extraction method on the concentrations of selected bioactive compounds in mandarin juice. | 2003 | J. Agric. Food Chem. | pmid:14640582 |
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| Manthey JA et al. | Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. | 2011 | J. Agric. Food Chem. | pmid:21133365 |
| Yoon JH et al. | Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation. | 2011 | J. Agric. Food Chem. | pmid:21126077 |
| Wu HY et al. | Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. | 2011 | J. Agric. Food Chem. | pmid:21314126 |
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| Yoshizaki N et al. | A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes. | 2017 | J. Dermatol. Sci. | pmid:28629701 |
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| Funaro A et al. | Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin. | 2016 | J. Food Sci. | pmid:27095513 |
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