| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lai HC et al. | Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. | 2011 | PLoS ONE | pmid:22140566 |
| Qiu P et al. | Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. | 2010 | Mol Nutr Food Res | pmid:20397199 |
| Akachi T et al. | Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats. | 2010 | J. Nutr. Sci. Vitaminol. | pmid:20354348 |
| Vauzour D et al. | Polyphenols and human health: prevention of disease and mechanisms of action. | 2010 | Nutrients | pmid:22254000 |
| Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
| Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
| Han S et al. | Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong. | 2010 | J. Agric. Food Chem. | pmid:20698540 |
| Stuetz W et al. | Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. | 2010 | J. Agric. Food Chem. | pmid:20420369 |
| Lewin G et al. | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. | 2010 | J. Nat. Prod. | pmid:20356063 |
| Ishii K et al. | Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | 2010 | Cancer Invest. | pmid:19863351 |
| Lin LW et al. | [Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods]. | 2010 | Zhong Yao Cai | pmid:20575406 |
| Asami Y et al. | Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources. | 2010 | BMC Pharmacol. | pmid:20537191 |
| Lust S et al. | The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562. | 2010 | Mol Nutr Food Res | pmid:20077418 |
| Ayala-Zavala JF et al. | Antioxidant enrichment and antimicrobial protection of fresh-cut fruits using their own byproducts: looking for integral exploitation. | 2010 | J. Food Sci. | pmid:21535513 |
| Adepoju G and Adeyemi T | Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin. | 2010 | J Young Pharm | pmid:21042484 |
| Sun Y et al. | Simultaneous determination of flavonoids in different parts of Citrus reticulata 'Chachi' fruit by high performance liquid chromatography-photodiode array detection. | 2010 | Molecules | pmid:20714303 |
| Yamanishi Y et al. | Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework. | 2010 | Bioinformatics | pmid:20529913 |
| Androutsopoulos VP et al. | Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. | 2009 | BMC Cancer | pmid:19531241 |
| Walle T | Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. | 2009 | Int J Mol Sci | pmid:20087474 |
| Zhou DY et al. | UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii. | 2009 | J Pharm Biomed Anal | pmid:19428213 |
| Quintin J et al. | Synthesis and biological evaluation of a series of tangeretin-derived chalcones. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19013795 |
| Quintin J et al. | Semisynthesis and antiproliferative evaluation of a series of 3'-aminoflavones. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19457664 |
| Yi LZ et al. | Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods. | 2009 | Anal. Chim. Acta | pmid:19664461 |
| Arafa el-SA et al. | Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. | 2009 | Cancer Res. | pmid:19903849 |
| Ionta M et al. | Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction. | 2009 | Cancer Cell Int. | pmid:19678939 |
| Zheng G et al. | Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection. | 2009 | J. Agric. Food Chem. | pmid:19722565 |
| Quintieri L et al. | Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. | 2008 | Biochem. Pharmacol. | pmid:18191104 |
| Bracke ME et al. | Plant polyphenolics as anti-invasive cancer agents. | 2008 | Anticancer Agents Med Chem | pmid:18288920 |
| Wang Z et al. | Validated reversed phase LC method for quantitative analysis of polymethoxyflavones in citrus peel extracts. | 2008 | J Sep Sci | pmid:18095294 |
| Sekiguchi H et al. | Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. | 2008 | J Clin Biochem Nutr | pmid:18818744 |
| Akao Y et al. | Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. | 2008 | Bioorg. Med. Chem. | pmid:18282757 |
| Satsu H et al. | Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals. | 2008 | J. Agric. Food Chem. | pmid:18540626 |
| Miller EG et al. | Inhibition of oral carcinogenesis by citrus flavonoids. | 2008 | Nutr Cancer | pmid:18444138 |
| Ho SC and Lin CC | Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels. | 2008 | J. Agric. Food Chem. | pmid:18683945 |
| Xu GH et al. | Minerals, phenolic compounds, and antioxidant capacity of citrus peel extract by hot water. | 2008 | J. Food Sci. | pmid:18211343 |
| Abe S et al. | Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland. | 2007 | J Med Food | pmid:17472462 |
| Fan K et al. | Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice. | 2007 | J Med Food | pmid:17472461 |
| Li S et al. | Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17035106 |
| Walle UK and Walle T | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. | 2007 | Drug Metab. Dispos. | pmid:17709371 |
| Green CO et al. | Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography. | 2007 | Biomed. Chromatogr. | pmid:17080505 |
| Ohtani H et al. | Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. | 2007 | Pharm. Res. | pmid:17492365 |
| Johann S et al. | Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. | 2007 | Mem. Inst. Oswaldo Cruz | pmid:17923995 |
| Nishimuta H et al. | Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. | 2007 | Biopharm Drug Dispos | pmid:17876860 |
| Eguchi A et al. | Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. | 2007 | Biofactors | pmid:18806314 |
| Malemud CJ | Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways. | 2007 | Curr Opin Pharmacol | pmid:17398158 |
| Buisson D et al. | Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites. | 2007 | J. Nat. Prod. | pmid:17559266 |
| Walle T | Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? | 2007 | Semin. Cancer Biol. | pmid:17574860 |
| Choi SY et al. | Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits. | 2007 | Biol. Pharm. Bull. | pmid:17409518 |
| Takano K et al. | Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16971492 |
| Chen KH et al. | Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. | 2007 | Biochem. Pharmacol. | pmid:17067555 |